MAOB, monoamine oxidase B, 4129

N. diseases: 152; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.350 Biomarker disease BEFREE Both A1K1 and A2K2 showed high binding affinities against various proteins involved in depression and Alzheimer's mechanisms like monoamine oxidase B, acetylcholinesterase, norepinephrine transporter 2, serotonin transporter, dopamine receptor, serotonin receptor modulator, and beta-amyloid targets. 30964563 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.350 Biomarker disease BEFREE Human monoamine oxidase B (MAO-B) catalyzes the oxidation of amines and is inhibited for the treatment of both Parkinson's disease and depression. 30964996 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.350 Biomarker disease BEFREE MAO-A and MAO-B may be considered as targets for inhibitors to treat neurodegenerative diseases and depression and for managing symptoms associated with Parkinson's and Alzheimer's diseases. 29496172 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.350 Biomarker disease BEFREE Accordingly, small-molecule MAO-B inhibitors potentially alleviate the symptoms of dopamine-linked neuropathologies such as depression or Parkinson's disease. 29552556 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.350 Biomarker disease PSYGENET Recently, microsatellite polymorphisms have been reported to be associated with four genes, GABRB3, MAOB, PAH, and SLC6A4, and their relationships have been tested to five symptom factors: hallucinations, delusions, negative symptoms, mania, and depression. 22414661 2012
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.350 Biomarker disease PSYGENET We tested four genes [phenylalanine hydroxylase (PAH), the serotonin transporter (SLC6A4), monoamine oxidase B (MAOB), and the gamma-aminobutyric acid A receptor beta-3 subunit (GABRB3)] for their impact on five schizophrenia symptom factors: delusions, hallucinations, mania, depression, and negative symptoms. 19268543 2009
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.350 GeneticVariation disease BEFREE This study aimed to investigate associations between MAOA and MAOB polymorphisms and personality traits of positive and negative emotionality in healthy volunteers, to elucidate mechanisms underlying personality and the risk for depression. 19657584 2009
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.350 Biomarker disease PSYGENET This study aimed to investigate associations between MAOA and MAOB polymorphisms and personality traits of positive and negative emotionality in healthy volunteers, to elucidate mechanisms underlying personality and the risk for depression. 19657584 2009