|
Mucinous Adenocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Syk, MAP4 and calpain-1 appeared to significantly correlate with each other in the whole cohort, with calpain-1 being more highly associated with MAP4 and Syk in mucinous carcinomas.
|
30737623 |
2019 |
|
Heart Failure, Right-Sided
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using an integrated systems genomic and functional biology approach, we identified an RVF-specific gene module, for which WIPI1 served as a hub and HSPB6 and MAP4 as drivers, and confirmed the ventricular specificity of Wipi1, Hspb6, and Map4 transcriptional changes in adult murine models of pressure overload induced RV- versus LV- failure.
|
31021818 |
2019 |
|
ovarian neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of Syk and MAP4 proteins in ovarian cancer.
|
30737623 |
2019 |
|
Malignant neoplasm of ovary
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of Syk and MAP4 proteins in ovarian cancer.
|
30737623 |
2019 |
|
Right ventricular failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using an integrated systems genomic and functional biology approach, we identified an RVF-specific gene module, for which WIPI1 served as a hub and HSPB6 and MAP4 as drivers, and confirmed the ventricular specificity of Wipi1, Hspb6, and Map4 transcriptional changes in adult murine models of pressure overload induced RV- versus LV- failure.
|
31021818 |
2019 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of Syk and MAP4 proteins in ovarian cancer.
|
30737623 |
2019 |
|
Myocardial Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Heart specimens of tetralogy of Fallot (TOF) patients, myocardial infarction (MI) and transverse aortic constriction (TAC) mouse models were collected to determine changes of microtubule associated protein 4 (MAP4) phosphorylation.
|
30327268 |
2018 |
|
Tetralogy of Fallot
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Elevated cardiac phosphorylation of MAP4 (S737 and S760) was observed in TOF patients, MI and TAC mouse models.
|
30327268 |
2018 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found the expression levels of MAP4 protein in LADC tissues to be significantly higher than those in noncancerous tissues.
|
29743960 |
2018 |
|
Tumor Progression
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The purpose of this study was to investigate the level of expression of MAP4 in lung adenocarcinoma (LADC) samples and to evaluate its prognostic value and the influence on cancer progression in LADC patients.
|
29743960 |
2018 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
By activating the ERK-c-Jun-vascular endothelial growth factor A signaling pathway, MAP4 promotes cell invasion and migration in vitro, tumor growth and metastasis in mouse models.
|
26876215 |
2016 |
|
Squamous cell carcinoma of esophagus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical staining of operative tissues indicated that MAP4 expression was associated with tumor stage, lymph node metastasis and shorter survival of the patients with esophageal squamous cell carcinoma (ESCC).
|
26876215 |
2016 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical staining of operative tissues indicated that MAP4 expression was associated with tumor stage, lymph node metastasis and shorter survival of the patients with esophageal squamous cell carcinoma (ESCC).
|
26876215 |
2016 |
|
Dwarfism
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These observations demonstrated that MAP4 mutations contribute to the clinical spectrum of centrosomal defects and confirmed the complex role of a centrosomal protein in centrosomal, ciliary, and Golgi regulation associated with severe short stature.
|
25323976 |
2015 |
|
Malignant neoplasm of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
Based on these data, we proposed the set of potential biomarkers for detection of prostate cancer and discrimination between prostate tumors with different malignancy and aggressiveness: BHLHE40, FOXP1, LOC285205, ITGA9, CTDSPL, FGF12, LOC440944/SETD5, VHL, CLCN2, OSBPL10/ZNF860, LMCD1, FAM19A4, CAND2, MAP4, KY, and LRRC58.
|
26491211 |
2015 |
|
Prostate carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Based on these data, we proposed the set of potential biomarkers for detection of prostate cancer and discrimination between prostate tumors with different malignancy and aggressiveness: BHLHE40, FOXP1, LOC285205, ITGA9, CTDSPL, FGF12, LOC440944/SETD5, VHL, CLCN2, OSBPL10/ZNF860, LMCD1, FAM19A4, CAND2, MAP4, KY, and LRRC58.
|
26491211 |
2015 |
|
Malignant neoplasm of urinary bladder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We also analyzed gene expression of MAP4 in 34 patients with bladder cancer using immunohistochemical staining assay.
|
24140250 |
2014 |
|
Bladder Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We also analyzed gene expression of MAP4 in 34 patients with bladder cancer using immunohistochemical staining assay.
|
24140250 |
2014 |
|
Peripheral Neuropathy
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Seventeen polymorphisms in regulatory and coding regions of genes controlling VCR targets (TUBB1, MAP4, ACTG1 and CAPG) or potentially influencing VCR levels (ABCB1 and CYP3A5) were investigated for an association with peripheral neuropathy and outcome in childhood ALL patients.
|
25084203 |
2014 |
|
Carcinoma of bladder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We also analyzed gene expression of MAP4 in 34 patients with bladder cancer using immunohistochemical staining assay.
|
24140250 |
2014 |
|
Carcinoma of urinary bladder, invasive
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results indicated that the cAMP/PKA signaling pathway might inhibit bladder cancer cell invasion by targeting MAP4-dependent microtubule dynamics, which could be exploited for the therapy of invasive bladder cancer.
|
24140250 |
2014 |
|
Peripheral Nervous System Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Seventeen polymorphisms in regulatory and coding regions of genes controlling VCR targets (TUBB1, MAP4, ACTG1 and CAPG) or potentially influencing VCR levels (ABCB1 and CYP3A5) were investigated for an association with peripheral neuropathy and outcome in childhood ALL patients.
|
25084203 |
2014 |
|
HIV-1 infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study we demonstrate that knockdown using DNAL1 and MAP4 siRNAs and shRNAs inhibits HIV-1 infection regardless of envelope.
|
22018492 |
2012 |
|
Adenovirus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
MAP4 overdecoration of microtubules via adenovirus infection in vitro or following pressure overloading in vivo reduces the speed and average distance of mRNP movement.
|
18178719 |
2008 |
|
Cardiovascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Alzheimer's disease-related genes, such as APOE, A2M, PON2 and MAP4, and cardiovascular disease-associated genes, including COMT, CBS and WNK1, all congregated in a single module.
|
18842138 |
2008 |