Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Thus, we consider that the Arg5His mutation is an authentic tau gene abnormality responsible for the patient's tau pathology and late-onset dementia.
|
11921059 |
2002 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The deposition of tau protein aggregates in the brain is a pathological hallmark of dementia; and the hippocampus, a brain structure known to be critical in processing learning and memory, is one of the first and most heavily affected regions.
|
26758828 |
2016 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
One group of neurodegenerative dementias known as FTDP-17 (fronto-temporal dementia with Parkinsonism linked to chromosome 17) is directly linked genetically to mutations in the tau gene, demonstrating that Tau misfunction can cause neuronal cell death and dementia.
|
16495230 |
2006 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that both MAPT H1/H1 genotype and APOE ε4 allele lead to a more rapid progression to dementia among MCI subjects, probably mediating an increased rate of amyloid-β and tau brain deposition.
|
20930301 |
2010 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The tau gene has been found to be the locus of dementia with rigidity linked to chromosome 17.
|
10374757 |
1999 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
They show that dysfunction of Tau protein is sufficient to cause neurodegeneration and dementia.
|
29497399 |
2018 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
MAPT H1/H1 genotype was an independent predictor of dementia risk (odds ratio = 12.1) and the H1 versus H2 haplotype was associated with a 20% increase in transcription of 4-repeat tau in Lewy body disease brains.
|
19812213 |
2009 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
MAPT H1 Haplotype is Associated with Late-Onset Alzheimer's Disease Risk in APOEɛ4 Noncarriers: Results from the Dementia Genetics Spanish Consortium.
|
26444794 |
2016 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17.
|
9641683 |
1998 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this article, we describe a novel missense mutation, S320F, in the tau gene in a family with presenile dementia.
|
11891833 |
2002 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Dementia caused by Alzheimer's disease (AD) is mainly characterized by accumulation in the brain of extra- and intraneuronal amyloid-β (Aβ) and tau proteins, respectively, which selectively affect specific regions, particularly the neocortex and the hippocampus.
|
27792010 |
2017 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We have assessed whether apolipoprotein E (ApoE) genotype influences the age of onset of dementia in a series of families with frontal temporal dementia with defined mutations in the tau gene.
|
10076900 |
1999 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Alzheimer's Disease (AD) is an age-dependent neurodegenerative disorder, the most common type of dementia that is clinically characterized by the presence of beta-amyloid (Aβ) extracellularly and intraneuronal tau protein tangles that eventually leads to the onset of memory and cognition impairment, development of psychiatric symptoms and behavioral disorders that affect basic daily activities.
|
31642777 |
2019 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Beta-amlyoid 1-42 and tau-protein in cerebrospinal fluid of patients with Parkinson's disease dementia.
|
16899997 |
2006 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study is a reappraisal of the strong association of APOE variability with AD in southern India when compared to other dementia groups, while the transcriptional differences between MAPT haplotypes have a limited role in Indian dementia patients.
|
27705964 |
2016 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Then we performed neuroimaging and genetic analysis of MAPT and other dementia-related genes in the proband.
|
21555888 |
2011 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Levels of Aβ(42) and PHF-τ in cerebral cortex were correlated more strongly in the Dementia group, and these measures had independent explanatory power for dementia beyond those of standard neuropathologic indices.
|
25575135 |
2015 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
P10636 (microtubule-associated protein tau, that is involved in diseases like dementia etc.) was found to be the commonly screened target by about seventy percent of these phytochemicals.
|
29320554 |
2018 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the MAPT gene, which encodes the tau protein, are associated with several neurodegenerative diseases, including frontotemporal dementia (FTD), dementia with epilepsy, and other types of dementia.
|
30696811 |
2019 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Alzheimer's disease (AD) is the most common form of dementia and is distinguished from other dementias by observation of extracellular Amyloid-β (Aβ) plaques and intracellular neurofibrillary tangles, comprised of fibrils of Aβ and tau protein, respectively.
|
30123109 |
2018 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although it is believed that tau protein abnormalities and/or the loss of its functions results in neurodegeneration and dementia, the mechanism of tauopathy remains obscure.
|
29973863 |
2018 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In addition, genetic variation in the apolipoprotein E (APOE), catechol-O-methyltransferase (COMT), microtubule-associated protein tau (MAPT), and glucocerebrosidase (GBA) genes may confer risk for cognitive impairment in PD; and gait disturbance may also indicate an increased risk for dementia.
|
24757111 |
2014 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
5' splice site mutations in tau associated with the inherited dementia FTDP-17 affect a stem-loop structure that regulates alternative splicing of exon 10.
|
10329720 |
1999 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cognitive and <sup>18</sup> F-florbetapir positron emission tomography (PET) data were compared in patients with NT1 aged ≥ 65 years (n = 23) and in age- and sex-matched controls free of clinical dementia selected from the Alzheimer's Disease Neuroimaging Initiative (ADNI; n = 69) and the Multi-Domain Intervention Alzheimer's Prevention Trial (MAPT-18F AV45-PET; n = 23) cohorts.
|
30387527 |
2019 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The paradigm of Alzheimer's disease (AD) is one subject to frequent change: what was thought to be a rare form of pre-senile dementia was revealed as a wide-spread malady; where amyloid-β was deemed the sole causative agent for the better part of 20 years, tau protein was shown to play a crucial role in AD genesis.
|
21694453 |
2011 |