Parkinsonian Disorders
|
0.700 |
Biomarker
|
group |
BEFREE |
Computational Investigation of RNA A-Bulges Related to the Microtubule-Associated Protein Tau Causing Frontotemporal Dementia and Parkinsonism.
|
30517788 |
2019 |
Parkinsonian Disorders
|
0.700 |
Biomarker
|
group |
BEFREE |
The assembly of tau protein into abnormal filaments and brain cell degeneration are characteristic of a number of human neurodegenerative diseases, including Alzheimer's disease and frontotemporal dementia and parkinsonism linked to chromosome 17.
|
30905766 |
2019 |
Parkinsonian Disorders
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Tau aggregation and seeding analyses of two novel MAPT variants found in patients with motor neuron disease and progressive parkinsonism.
|
31027853 |
2019 |
Parkinsonian Disorders
|
0.700 |
Biomarker
|
group |
BEFREE |
Tau protein is found to be aggregated and hyperphosphorylated (p-tau) in many neurologic disorders, including Parkinson disease (PD) and related parkinsonisms, Alzheimer disease, traumatic brain injury, and even in normal aging.
|
31085590 |
2019 |
Parkinsonian Disorders
|
0.700 |
GeneticVariation
|
group |
BEFREE |
[<sup>11</sup> C]PBB3-PET can capture four-repeat tau pathologies characteristic of N279K mutant frontotemporal dementia and parkinsonism linked to chromosome 17/MAPT.
|
30773680 |
2019 |
Parkinsonian Disorders
|
0.700 |
Biomarker
|
group |
BEFREE |
Four of 22 cases with severe putaminal MAPT deposition were documented as having developed parkinsonism.
|
31206007 |
2019 |
Parkinsonian Disorders
|
0.700 |
Biomarker
|
group |
BEFREE |
NF-L and tau protein in CSF might be useful for mortality prognosis in patients with parkinsonian disorders and should be investigated in larger studies.
|
31070772 |
2019 |
Parkinsonian Disorders
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Genetic variation at the microtubule-associated protein tau locus is associated with clinical parkinsonism.
|
31234228 |
2019 |
Parkinsonian Disorders
|
0.700 |
GeneticVariation
|
group |
BEFREE |
The identification of mutations in MAPT, the gene that encodes tau, causing dementia and parkinsonism established the notion that tau aggregation is responsible for the development of disease.
|
28789904 |
2018 |
Parkinsonian Disorders
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Carbazole and 2-arylquinoline binding was only observed in cases with Alzheimer's disease and one case with frontotemporal dementia and parkinsonism linked to chromosome 17 exhibiting a R406W MAPT mutation.
|
29716656 |
2018 |
Parkinsonian Disorders
|
0.700 |
Biomarker
|
group |
BEFREE |
The aggregation of NFTs, the abnormal hyperphosphorylation of tau protein, and the interaction between tau and alpha-synuclein may all contribute to the cell death and poor axonal transport observed in PD and Parkinsonism.
|
30333786 |
2018 |
Parkinsonian Disorders
|
0.700 |
GeneticVariation
|
group |
BEFREE |
The first mutations associated with frontotemporal lobar degeneration (FTLD) were found in the microtubule-associated protein tau (MAPT) gene on chromosome 17 in families with frontotemporal degeneration and parkinsonism (FTDP-17).
|
29253099 |
2018 |
Parkinsonian Disorders
|
0.700 |
GeneticVariation
|
group |
BEFREE |
MAPT mutation associated with frontotemporal dementia and parkinsonism (FTDP-17).
|
27905268 |
2017 |
Parkinsonian Disorders
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Haplotype-specific MAPT exon 3 expression regulated by common intronic polymorphisms associated with Parkinsonian disorders.
|
29084565 |
2017 |
Parkinsonian Disorders
|
0.700 |
GeneticVariation
|
group |
BEFREE |
As a result, 2 novel mutations in MAPT (p.D177V and p.P513A) were identified in a sporadic and familial patient with PNFA respectively, and one known mutation in MAPT (p.N279K) was detected in an FTD-parkinsonism family.
|
27311648 |
2016 |
Parkinsonian Disorders
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Analysing MAPT alternative splicing, the expression of 1N/4R isoform was inversely associated with global parkinsonism (p = 0.008) and bradykinesia (p = 0.008).
|
27458716 |
2016 |
Parkinsonian Disorders
|
0.700 |
Biomarker
|
group |
BEFREE |
Mutations in the genes that encode microtubule-associated protein tau (MAPT) and progranulin (PGRN) can manifest as symmetrical parkinsonism, including the phenotypes of Richardson syndrome and corticobasal syndrome (CBS).
|
26891767 |
2016 |
Parkinsonian Disorders
|
0.700 |
Therapeutic
|
group |
RGD |
Human Basic Fibroblast Growth Factor Inhibits Tau Phosphorylation via the PI3K/Akt-GSK3β Signaling Pathway in a 6-Hydroxydopamine-Induced Model of Parkinson's Disease.
|
27228974 |
2016 |
Parkinsonian Disorders
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Mutations in the gene encoding the microtubule-associated protein tau are associated with frontotemporal dementia and parkinsonism linked to chromosome 17.
|
25495175 |
2015 |
Parkinsonian Disorders
|
0.700 |
GeneticVariation
|
group |
BEFREE |
However, exome sequencing identified a missense mutation, N279K, in exon 10 of MAPT gene, verifying that the early parkinsonian symptoms in this family are caused by the genetic mutation for hereditary frontotemporal lobar dementia.
|
26295349 |
2015 |
Parkinsonian Disorders
|
0.700 |
Biomarker
|
group |
BEFREE |
GRN, C9ORF72, MAPT) have been excluded and when family history is complex and includes parkinsonism, motor neuron disease and frontotemporal dementia.
|
25853458 |
2015 |
Parkinsonian Disorders
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Agraphia in patients with frontotemporal dementia and parkinsonism linked to chromosome 17 with P301L MAPT mutation: dysexecutive, aphasic, apraxic or spatial phenomenon?
|
23121543 |
2014 |
Parkinsonian Disorders
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Mutations in the microtubule-associated protein tau gene (MAPT) cause frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17T).
|
24292008 |
2014 |
Parkinsonian Disorders
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Variants of the MAPT gene have been suggested to be associated with Parkinson's disease (PD) and to modify the risk for leucine-rich repeat kinase 2 (LRRK2) Parkinsonism.
|
24559644 |
2014 |
Parkinsonian Disorders
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Parkinsonism in frontotemporal dementia (FTD) was first described in families with mutations in the microtubule-associated protein tau (MAPT) and progranulin (PRGN) genes.
|
24998994 |
2014 |