ARSD, arylsulfatase D, 414

N. diseases: 163; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.100 Biomarker disease BEFREE The lack of any association, when considered with positive findings seen in ASD and schizophrenia, and negative findings in bipolar disorder suggests different pathways linking maternal immune activation and development of various neuropsychiatric disorders. 31312974 2020
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.100 Biomarker disease BEFREE Using a functional genomics approach, we integrated transcriptomic data from the developing human brain, genome-wide association findings for SCZ and ASD, protein interaction data, and gene expression signatures from SCZ and ASD postmortem cortex to 1) organize genes into the developmental cellular and molecular systems within which they operate, 2) identify neurodevelopmental processes associated with polygenic risk for SCZ and ASD across the allelic frequency spectrum, and 3) elucidate pathways and individual genes through which 22q11.2 copy number variants may confer risk for each disorder. 31500805 2020
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.100 Biomarker disease BEFREE In this UK population-based cohort study, 7921 mothers with genotype data from the Avon Longitudinal Study of Parents and Children (ALSPAC) underwent testing for association of maternal PRS for attention-deficit/hyperactivity disorder (ADHD PRS), autism spectrum disorder (ASD PRS), and schizophrenia (SCZ PRS) with 32 early-life exposures. 31042271 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.100 Biomarker disease BEFREE These mediation pathways were diagnostically specific and were not found for polygenic risk for ASD or schizophrenia. 30700802 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.100 Biomarker disease BEFREE However existing accounts fail to clarify: (i) how proposed theories differ in accounts of ASD vs. schizophrenia and (ii) whether the impairments result from weaker priors or enhanced likelihoods. 29757142 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.100 Biomarker disease BEFREE Schizophrenia and ASD appear to be associated with a similar pattern of metabolic abnormalities in the social brain. 28425060 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.100 GeneticVariation disease BEFREE We further combined these Psychiatric Genomics Consortium (PGC) ASD GWAS data with the recent PGC schizophrenia GWAS to identify additional regions which may be important in a common neurodevelopmental phenotype and identified 12 novel GWS loci. 28540026 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.100 GeneticVariation disease BEFREE In contrast, the prevalence of schizophrenia increased with age affecting a disproportionately large number of older (≥35 year) adult males (25%), compared to females (7.7%), with ASD. 28188687 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.100 AlteredExpression disease BEFREE ID genes were preferentially expressed in the cortex; ASD genes were expressed in the fetal cortex, cerebellum, and striatum; and genes associated with SCZ were expressed in the adolescent cortex. 28249166 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.100 GeneticVariation disease BEFREE Genetic predisposition scores for schizophrenia and ASD, and the number of genes impacted by rare copy number variants (CNV burden) did not predict global brain tissue volumes. 28763065 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.100 AlteredExpression disease BEFREE The dramatic effect on the expression of some SZ and ASD genes places HS, and perhaps other cellular stressors, into a common conceptual framework with disease-causing genetic variants. 24736721 2014