|
Bacterial Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Common human MBL gene polymorphisms result in low MBL expression and lead to recurring bacterial infections.
|
30457677 |
2019 |
|
Bacterial Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We found no evidence for an association between the MBL2 genotype and all-cause mortality, cardiovascular events or bacterial infections (pneumonia, urinary tract infection, fistula infection or other infections).
|
29514287 |
2018 |
|
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
LT recipients of MBL-deficient livers had a higher risk of bacterial infection (incidence rate ratio [IRR] 1.48 [95% confidence interval 1.04-2.09], p = 0.028), pneumonia (IRR 2.4 [95% confidence interval 1.33-4.33], p = 0.013), and septic shock (IRR 5.62 [95% confidence interval 1.92-16.4], p = 0.002) compared with recipients of MBL-deficient livers.
|
28649744 |
2018 |
|
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Most importantly, promising effect against MDR pathogens in this study has raised the probable chances of the utility of these phages for biological control of bacterial infection including MBL and ESBL strains.
|
29359149 |
2017 |
|
Bacterial Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Using expression quantitative trait loci (eQTL) analysis, we found that the C7 rs6876739 CC genotypes and mannan-binding lectin (MBL2) gene polymorphisms of liver donors were significantly associated with bacterial infection in recipients.
|
27063552 |
2016 |
|
Bacterial Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
MBL2 medium/high-risk genotype and FCN2 medium/high-risk haplotype were associated with prolonged duration of FN (P = 0.007 and P = 0.001, respectively) and increased number of bacterial infections (P = 0.001 and P = 0.002, respectively).
|
24453114 |
2014 |
|
Bacterial Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In one additional MBL level study the number of FN episodes, bacteremia and severe bacterial infection were increased in patients with MBL levels < 100 µg/L as compared to those with MBL levels of 100-999 µg/L.
|
21557458 |
2011 |
|
Bacterial Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Using logistic regression for patients with SLE, a high MBL expression genotype was independently associated with renal disorders (OR 2.49, 95% CI 1.15-5.39, p = 0.021) and had a protective effect against serious bacterial infections (OR 0.29, 95% CI 0.12-0.71, p = 0.007).
|
21532056 |
2011 |
|
Bacterial Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Independent variables associated with graft or patient survival were as follows: receiving a graft from a donor with an exon 1 MBL2 variant genotype [adjusted hazard ratio (aHR), 9.64; 95% confidence interval (CI), 2.59-36.0], the Model for End-Stage Liver Disease score (aHR, 1.14; 95% CI, 1.05-1.23), and bacterial infections (aHR, 11.1; 95% CI, 2.73-44.9).
|
19790141 |
2009 |
|
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings provide evidence of gene-gene interaction in the pathogenesis of CF lung disease, whereby high TGF-beta1 production enhances the modulatory effect of MBL2 on the age of first bacterial infection and the rate of decline of pulmonary function.
|
18292811 |
2008 |
|
Bacterial Infections
|
0.100 |
Biomarker
|
group |
LHGDN |
These findings provide evidence of gene-gene interaction in the pathogenesis of CF lung disease, whereby high TGF-beta1 production enhances the modulatory effect of MBL2 on the age of first bacterial infection and the rate of decline of pulmonary function.
|
18292811 |
2008 |
|
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
We reanalyzed individual data from 675 patients from 5 adult studies and 1 pediatric study of MBL and severe bacterial infection.
|
18611155 |
2008 |
|
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Mannose-binding lectin (MBL) is an important factor of the innate immune system, and MBL-initiated complement activation is an important early defense mechanism against various bacterial infections, including invasive meningococcal disease.
|
17484222 |
2007 |
|
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Mannose-binding lectin (MBL) may be involved in the biologic cascade of events initiated by wear debris and bacterial infection around loosened total hip arthroplasties (THAs).
|
17275645 |
2007 |
|
Bacterial Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Serum MBL levels were shown to correlate inversely with the number of bacterial infections (r = -0.13, p = 0.03).
|
17552055 |
2007 |
|
Bacterial Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Likewise low concentration or decreased biological activity of mannose-binding lectin (MBL) is associated with higher incidence of bacterial infections during childhood.
|
16337490 |
2006 |
|
Bacterial Infections
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Polymorphisms in CD14, mannose-binding lectin, and Toll-like receptor-2 are associated with increased prevalence of infection in critically ill adults.
|
15753758 |
2005 |
|
Bacterial Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Association of MBL gene polymorphisms with major bacterial infection in patients treated with high-dose chemotherapy and autologous PBSCT.
|
15674393 |
2005 |
|
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Clinical studies have shown that MBL insufficiency is associated with bacterial infection in patients with neutropenia and meningococcal sepsis.
|
14614673 |
2003 |