MBL2, mannose binding lectin 2, 4153

N. diseases: 563; N. variants: 21
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019163
Disease: Hepatitis B
Hepatitis B
0.100 GeneticVariation disease BEFREE The present study aimed to identify the association between MBL2 gene polymorphisms and HCC in patients with hepatitis B virus (HBV)-related cirrhosis in the Chinese population. 27298104 2016
CUI: C0019163
Disease: Hepatitis B
Hepatitis B
0.100 GeneticVariation disease BEFREE Our approach includes the study of the MBL2 gene genotype as well as ultra-deep sequencing of the HBV viruses obtained from the plasma of 50 treatment naïve patients with chronic HBV infection. 27824315 2016
CUI: C0019163
Disease: Hepatitis B
Hepatitis B
0.100 GeneticVariation disease BEFREE We studied allele and haplotype frequencies of -221C/G and codon 54G/A in MBL2 gene to reveal their relationship with the developing and progression of hepatitis B virus (HBV)-related liver diseases. 26857650 2016
CUI: C0019163
Disease: Hepatitis B
Hepatitis B
0.100 Biomarker disease BEFREE The innate immunity gene mannose-binding lectin2 (MBL2) has played an important role in hepatitis B virus (HBV) infection, and the relationship between MBL2 variants and hepatocellular carcinoma (HCC) risk has not yet been identified. 27557564 2016
CUI: C0019163
Disease: Hepatitis B
Hepatitis B
0.100 GeneticVariation disease BEFREE A meta-analysis was performed to examine the association between mbl2 polymorphisms and chronicity or progression of hepatitis B infection. 24116040 2013
CUI: C0019163
Disease: Hepatitis B
Hepatitis B
0.100 GeneticVariation disease BEFREE Tag single nucleotide polymorphisms (SNPs) were used to investigate the relationship between MBL2 gene polymorphisms and susceptibility to chronic hepatitis B virus (HBV) infection by comparing 996 chronic HBV infection cases to 301 acute infection controls. 23417614 2013
CUI: C0019163
Disease: Hepatitis B
Hepatitis B
0.100 AlteredExpression disease BEFREE Our results provide preliminary evidence that inheritance of codon 52 genotypes and XY/O haplotype associated with low MBL level substantially determine the outcome of HBV infection in a sympatrically isolated South Indian population. 20193030 2010
CUI: C0019163
Disease: Hepatitis B
Hepatitis B
0.100 Biomarker disease BEFREE Our findings may indicate that MBL has a protective role against HBV infection in the studied population. 20712490 2010
CUI: C0019163
Disease: Hepatitis B
Hepatitis B
0.100 GeneticVariation disease LHGDN [Relationship between the gene mutations of mannose binding protein and the progression of hepatitis B infection]. 18543229 2008
CUI: C0019163
Disease: Hepatitis B
Hepatitis B
0.100 Biomarker disease BEFREE Mannose-binding lectin (MBL) is involved in host's response to several infections including hepatitis B but little is known about MBL and hepatitis C virus (HCV) infection. 18592362 2008
CUI: C0019163
Disease: Hepatitis B
Hepatitis B
0.100 GeneticVariation disease BEFREE MBL gene polymorphism at codon 54 was not associated with the clearance of hepatitis B virus infection nor progression of disease in chronic hepatitis B virus infection. 15716605 2005
CUI: C0019163
Disease: Hepatitis B
Hepatitis B
0.100 GeneticVariation disease BEFREE Mannose binding lectin genotypes influence recovery from hepatitis B virus infection. 15994813 2005
CUI: C0019163
Disease: Hepatitis B
Hepatitis B
0.100 GeneticVariation disease BEFREE The roles of MBL and its gene (mbl2) polymorphisms, -221X/Y and codon 54A/B, in hepatitis B virus (HBV) infection were investigated in this study. 16231358 2005
CUI: C0019163
Disease: Hepatitis B
Hepatitis B
0.100 GeneticVariation disease BEFREE Our results indicate that a mutation of the MBL gene might influence the clinical outcome of HBV infection in Vietnamese patients. 12517417 2003
CUI: C0019163
Disease: Hepatitis B
Hepatitis B
0.100 GeneticVariation disease BEFREE In white patients there is an association between codon 52 mutation of the MBL gene and persistent hepatitis B virus (HBV) infection. 11063157 2000