|
Respiratory Tract Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Mannose-binding lectin (MBL) deficiency may increase risk of respiratory tract infection in adults unselected for IgG or IgG subclass levels.
|
31117958 |
2019 |
|
Respiratory Tract Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Children with MBL variant genotype had a mean of 59 days with symptoms of respiratory infection per year, compared with 49 days in those with wild-type (P = 0.01).
|
28403045 |
2017 |
|
Respiratory Tract Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Any study was considered to be eligible for inclusion if it met the following criteria: the MBL gene polymorphism at codon 54 was determined, the outcome was recurrent respiratory tract infection in children and there were at least two comparison groups.
|
26810288 |
2016 |
|
Respiratory Tract Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Mannose-binding lectin (MBL) deficiency arising from polymorphisms in the coding and non-coding region on the MBL2 gene has been associated with more frequent and severe respiratory infections.
|
25939617 |
2015 |
|
Respiratory Tract Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The objective of this study was to explore the genetic polymorphisms and serum protein levels of MBL in Chinese pediatric patients with common infectious diseases, including recurrent respiratory infection (RRI), acute respiratory infection (ARI), active cytomegalovirus (CMV) infection, localized abscess, and otitis media.
|
22444663 |
2012 |
|
Respiratory Tract Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Mannose-binding lectin (MBL) deficiency is associated with susceptibility to respiratory infections.
|
20688922 |
2011 |
|
Respiratory Tract Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
The role of the innate immune protein mannose-binding lectin (MBL) in host defence against severe respiratory infection remains controversial.
|
20078874 |
2010 |
|
Respiratory Tract Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
An association between mannan-binding lectin (MBL) insufficiency and recurrent respiratory infections was also confirmed.
|
19767106 |
2009 |
|
Respiratory Tract Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Mannose-binding lectin polymorphisms and recurrent respiratory tract infection in Chinese children.
|
19169708 |
2009 |
|
Respiratory Tract Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Deficient MBL2 genotypes were not associated with an increased risk of RTI (odds ratio, 0.71 [95% confidence interval, 0.25 to 2.05]) during years 1-4 of life.
|
18847375 |
2008 |
|
Respiratory Tract Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These preliminary results suggest, for the first time, an association between MBL level and respiratory tract infections in young men and a possible association between infections and MBL2 polymorphisms.
|
18729778 |
2008 |
|
Respiratory Tract Infections
|
0.100 |
AlteredExpression
|
group |
LHGDN |
These preliminary results suggest, for the first time, an association between MBL level and respiratory tract infections in young men and a possible association between infections and MBL2 polymorphisms.
|
18729778 |
2008 |
|
Respiratory Tract Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We evaluated the prevalence of IgA, IgM, IgG, and IgG subclass deficiencies, impairment in the antibody response against pneumococcal polysaccharides, G2m(n) allotypes, Fc gamma RIIa polymorphisms, partial C2 and partial C4 deficiency, promoter polymorphisms in MBL2, and lymphocyte subset deficiencies in a control population and in consecutive children with recurrent respiratory infections.
|
17110469 |
2007 |
|
Respiratory Tract Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The protective role of low-producer mbl-2 genotypes against TBC together with the positive correlation observed between non-producer mbl-2 alleles and TBC incidence, suggest a balancing selection: in spite of an increased susceptibility to respiratory infections associated with MBL deficiency, mbl-2 deficient alleles would have been selected along different populations as a consequence of its selective advantage against intracellular pathogens, such as M. tuberculosis.
|
16500704 |
2006 |
|
Respiratory Tract Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Careful microbiological assessment is needed in patients with recurrent respiratory infection and the presence of B multivorans should trigger further immunological investigation including assessment of MBL status.
|
15681508 |
2005 |
|
Respiratory Tract Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results indicate that mannan-binding lectin insufficiency, with or without a coexisting immune defect, is associated with the occurrence of recurrent respiratory infections in childhood, and this relationship is particularly strong and statistically significant in children with concomitant impairments of humoral immunity.
|
15086395 |
2004 |
|
Respiratory Tract Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Furthermore, we demonstrated that the prevalence of the codon 54 mutation of the MBL gene in 62 patients having repeated respiratory infections was significantly higher compared with healthy control subjects (54.8% vs 32.7%).
|
15249448 |
2004 |
|
Respiratory Tract Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Low MBL-producing genotypes were associated with more frequent admissions to hospital with respiratory infection, suggesting that the MBL2 gene is disease-modifying in COPD.
|
12761563 |
2003 |
|
Respiratory Tract Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
MBL variant allele carriers had higher disease activity (SLEDAI-index) in a 2-year follow-up period (P = 0.02) and had an increased risk of acquiring complicating infections in general (P = 0.03) and respiratory infections in particular (P = 0.0006).
|
11781711 |
2001 |
|
Respiratory Tract Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Acute respiratory tract infections and mannose-binding lectin insufficiency during early childhood.
|
11255386 |
2001 |