|
Sepsis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study aimed to examine the association of DIC with levels of collectin kidney 1 (CL-K1), a novel collectin of the complement system, and mannose-binding lectin (MBL), a classical-type collectin in patients with sepsis.
|
30808212 |
2019 |
|
Sepsis
|
0.100 |
Biomarker
|
disease |
BEFREE |
<b>Background:</b> Mannose-binding lectin (MBL) is an innate immune protein with strong biologic plausibility for protecting against influenza virus-related sepsis and bacterial co-infection.
|
31139182 |
2019 |
|
Sepsis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In our cohort of VLBWI, MBL levels were genetically determined, but not associated with gestational age or sepsis in the first 21 days of life.
|
29807983 |
2018 |
|
Sepsis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Mannose-binding lectin levels had no association with infection status at admission, or with progression from systemic inflammatory response syndrome to sepsis or septic shock.
|
27820718 |
2017 |
|
Sepsis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found no association between MBL levels and sepsis risk in the whole cohort.
|
28558032 |
2017 |
|
Sepsis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Generally, sepsis was associated with low serum MBL and low ficolin-2 concentrations on admission.
|
26850322 |
2016 |
|
Sepsis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The role of MBL2 gene polymorphism in sepsis incidence.
|
26823854 |
2015 |
|
Sepsis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this large, well-defined cohort of immune competent adult patients, no associations between MBL2 genotype and sepsis susceptibility or outcome were identified.
|
25969530 |
2015 |
|
Sepsis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Twenty-nine studies addressing four MBL polymorphisms (-550G/C, -221G/C, structure variant A/O, Gly54Asp) were analysed for susceptibility to sepsis and one study for sepsis-related mortality.
|
24398289 |
2014 |
|
Sepsis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Serum MBL levels were significantly lower in infants with sepsis compared with the control group.
|
21681178 |
2012 |
|
Sepsis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A SNP in MBL2 and MPO gene was associated with septicemia and a SNP in the gene CYP2C8 was strongly associated with ONJ.
|
21883476 |
2012 |
|
Sepsis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
MBL gene polymorphism was associated with increased frequency of clinical sepsis particularly with early neonatal sepsis and also with higher Tollner sepsis scores and increased frequency of patent ductus arteriosus in infants.
|
20453525 |
2010 |
|
Sepsis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Role of mannose-binding lectin in nosocomial sepsis in critically ill neonates.
|
20732365 |
2010 |
|
Sepsis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the first study, the median MBL level was decreased in newborns with confirmed sepsis (170 μg/l) compared with newborns without sepsis (1450 μg/l).
|
20488866 |
2010 |
|
Sepsis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, low MBL levels pre-transplant predisposed patients to sepsis, fungal and viral infection.
|
19430499 |
2010 |
|
Sepsis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to investigate the possible associations between polymorphisms in CHIT1, MBL2 and sepsis in adult patients treated with high-dose chemotherapy for AML.
|
20331735 |
2010 |
|
Sepsis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether polymorphisms in the MBL2 gene and the serum level are associated with the severity and prognosis of sepsis.
|
19891773 |
2009 |
|
Sepsis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Subsequently, data were reassessed to extend previous MBL and sepsis associations, with adjustment for known outcome predictors.
|
18611155 |
2008 |
|
Sepsis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, in a multivariate analysis MBL insufficiency was associated with the development of the most severe forms of sepsis (P = .007), acute respiratory failure (P = .009), multiorgan dysfunction syndrome (P = .036), intensive care unit admission (P = .020), and death (P = .003).
|
18582923 |
2008 |
|
Sepsis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No relationship was found between MBL genotype and the risk of nosocomial sepsis or pneumonia, even after correction for birth-weight, perhaps because of an insufficient correlation between genotype and the concentration of functional MBL.
|
18031556 |
2008 |
|
Sepsis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
The role of mannose-binding lectin in susceptibility to infection in preterm neonates.
|
18317236 |
2008 |
|
Sepsis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The variant alleles in the mannose binding lectin-2 (MBL-2) gene have been associated with MBL deficiency and increased susceptibility to sepsis.
|
17133182 |
2007 |
|
Sepsis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Low MBL levels at birth are associated with an increased risk of early-onset sepsis, culture-proven sepsis and pneumonia during the first month of life.
|
17711490 |
2007 |
|
Sepsis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this prospective cohort study was to determine the genetic association of sequence variations within the MBL gene with systemic infections and pulmonary short- and long-term complications in preterm infants below 32 weeks gestational age (GA).
|
17898783 |
2007 |
|
Sepsis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Median MBL function was lower in sepsis patients (0.18 U microL(-1)) than in controls (0.48 U microL(-1), P<0.001).
|
17064281 |
2006 |