MBP, myelin basic protein, 4155

N. diseases: 184; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.580 Biomarker disease BEFREE Approximately 82% electrophoretically homogeneous SCZ IgGs purified using several affinity sorbents including Sepharose with immobilized MBP hydrolyze specifically only MBP but not many other tested proteins. 30112774 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.580 AlteredExpression disease BEFREE Western blot analysis was used to compare protein levels of myelin basic protein, neurofilament heavy, autophagosome marker LC3, and microtubule marker α-tubulin in post-mortem human CB, CC, and AF in schizophrenia subjects (SZ) and matched normal controls (NC). 30735241 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.580 Biomarker disease PSYGENET Myelin basic protein and 2', 3'-cyclic nucleotide 3'-phosphodiesterase were also significantly decreased in the mouse model of SZ. 24788877 2014
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.580 Biomarker disease RGD Myelination deficit in a phencyclidine-induced neurodevelopmental model of schizophrenia. 22750584 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.580 Biomarker disease PSYGENET Reduced MBP mRNA in schizophrenia replicates findings in other brain regions and is consistent with oligodendrocyte involvement in the disorder. 22675524 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.580 AlteredExpression disease BEFREE Reduced MBP mRNA in schizophrenia replicates findings in other brain regions and is consistent with oligodendrocyte involvement in the disorder. 22675524 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.580 AlteredExpression disease BEFREE These findings indicate that altered expression levels of hnRNP C in the brain of patients with schizophrenia could be involved in the pathophysiology of this disease through alteration of the QKI isoform and myelin basic protein expression. 21684615 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.580 AlteredExpression disease LHGDN Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis. 19034380 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.580 AlteredExpression disease BEFREE In addition we performed an expression analysis of golli-MBP mRNA in post-mortem dorsolateral prefrontal cortex samples of schizophrenia patients, and matched controls. 19154657 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.580 AlteredExpression disease LHGDN These included alterations previously implicated in schizophrenia, such as oligodendrocyte-related proteins (myelin basic protein and transferrin), as well as malate dehydrogenase, aconitase, ATP synthase subunits and cytoskeleton-related proteins. 19110265 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.580 Biomarker disease PSYGENET In addition we performed an expression analysis of golli-MBP mRNA in post-mortem dorsolateral prefrontal cortex samples of schizophrenia patients, and matched controls. 19154657 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.580 Biomarker disease PSYGENET Correlation and factor analyses revealed that mRNA levels for genes that did exhibit differential expression in schizophrenia (MAG, CNP, SOX10, CLDN11, and PMP2), as opposed to those that did not (MOBP and MBP), loaded on separate factors. 16213148 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.580 AlteredExpression disease BEFREE Correlation and factor analyses revealed that mRNA levels for genes that did exhibit differential expression in schizophrenia (MAG, CNP, SOX10, CLDN11, and PMP2), as opposed to those that did not (MOBP and MBP), loaded on separate factors. 16213148 2006