Schizophrenia
|
0.580 |
Biomarker
|
disease |
BEFREE |
Approximately 82% electrophoretically homogeneous SCZ IgGs purified using several affinity sorbents including Sepharose with immobilized MBP hydrolyze specifically only MBP but not many other tested proteins.
|
30112774 |
2019 |
Schizophrenia
|
0.580 |
AlteredExpression
|
disease |
BEFREE |
Western blot analysis was used to compare protein levels of myelin basic protein, neurofilament heavy, autophagosome marker LC3, and microtubule marker α-tubulin in post-mortem human CB, CC, and AF in schizophrenia subjects (SZ) and matched normal controls (NC).
|
30735241 |
2019 |
Schizophrenia
|
0.580 |
Biomarker
|
disease |
PSYGENET |
Myelin basic protein and 2', 3'-cyclic nucleotide 3'-phosphodiesterase were also significantly decreased in the mouse model of SZ.
|
24788877 |
2014 |
Schizophrenia
|
0.580 |
Biomarker
|
disease |
RGD |
Myelination deficit in a phencyclidine-induced neurodevelopmental model of schizophrenia.
|
22750584 |
2012 |
Schizophrenia
|
0.580 |
Biomarker
|
disease |
PSYGENET |
Reduced MBP mRNA in schizophrenia replicates findings in other brain regions and is consistent with oligodendrocyte involvement in the disorder.
|
22675524 |
2012 |
Schizophrenia
|
0.580 |
AlteredExpression
|
disease |
BEFREE |
Reduced MBP mRNA in schizophrenia replicates findings in other brain regions and is consistent with oligodendrocyte involvement in the disorder.
|
22675524 |
2012 |
Schizophrenia
|
0.580 |
AlteredExpression
|
disease |
BEFREE |
These findings indicate that altered expression levels of hnRNP C in the brain of patients with schizophrenia could be involved in the pathophysiology of this disease through alteration of the QKI isoform and myelin basic protein expression.
|
21684615 |
2011 |
Schizophrenia
|
0.580 |
AlteredExpression
|
disease |
LHGDN |
Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis.
|
19034380 |
2009 |
Schizophrenia
|
0.580 |
AlteredExpression
|
disease |
BEFREE |
In addition we performed an expression analysis of golli-MBP mRNA in post-mortem dorsolateral prefrontal cortex samples of schizophrenia patients, and matched controls.
|
19154657 |
2009 |
Schizophrenia
|
0.580 |
AlteredExpression
|
disease |
LHGDN |
These included alterations previously implicated in schizophrenia, such as oligodendrocyte-related proteins (myelin basic protein and transferrin), as well as malate dehydrogenase, aconitase, ATP synthase subunits and cytoskeleton-related proteins.
|
19110265 |
2009 |
Schizophrenia
|
0.580 |
Biomarker
|
disease |
PSYGENET |
In addition we performed an expression analysis of golli-MBP mRNA in post-mortem dorsolateral prefrontal cortex samples of schizophrenia patients, and matched controls.
|
19154657 |
2009 |
Schizophrenia
|
0.580 |
Biomarker
|
disease |
PSYGENET |
Correlation and factor analyses revealed that mRNA levels for genes that did exhibit differential expression in schizophrenia (MAG, CNP, SOX10, CLDN11, and PMP2), as opposed to those that did not (MOBP and MBP), loaded on separate factors.
|
16213148 |
2006 |
Schizophrenia
|
0.580 |
AlteredExpression
|
disease |
BEFREE |
Correlation and factor analyses revealed that mRNA levels for genes that did exhibit differential expression in schizophrenia (MAG, CNP, SOX10, CLDN11, and PMP2), as opposed to those that did not (MOBP and MBP), loaded on separate factors.
|
16213148 |
2006 |