|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
Single SNP analysis showed that genetic variants in SLC30A10, TMEM18, GNPDA2, PRL, TFAP2B, BDNF, MTCH2, FTO, and MC4R were nominally associated with waist circumference (WC), BMI, and risk for abdominal or general obesity in the untreated patients with type 2 diabetes, as well as in the total group of patients with type 2 diabetes (untreated and treated) (p < 0.05).
|
31167208 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
In this first study of Arab descendants, we confirmed several known obesity (FTO, USP37, and RFX7), height (NSD1, MFAP2), and T2DM (TCF7L2, MC4R) associations; and report novel associations, like KCNK3 and RARB for T2DM.
|
29717269 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
FTO (OR = 1.71; CI<sub>95 %</sub> = 1.14-2.57; p = 0.008) and APOB (OR = 0.31; CI<sub>95 %</sub> = 0.14-0.72; p = 0.004) result is statistically associated to high blood pressure and FTO (OR = 2.0; CI<sub>95 %</sub> = 1.3-3.1; p = 0.001), GNB3 (OR = 2.69; CI<sub>95 %</sub> = 1.0-7.2; p = 0.04), IFI30 (OR = 2.0; CI<sub>95 %</sub> = 1.16-3.6; p = 0.01), and MC4R (OR = 1.81; CI<sub>95 %</sub> = 1.13-2.9; p = 0.01) to type 2 diabetes (T2D).
|
28035522 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
The interaction between MC4R genes with dietary factors plays a significant role in the development of obesity or Type 2 diabetes phenotypes.
|
26666384 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Six separate groups were identified.Individuals with a more modern birth year, an MC4R mutation, or in utero exposure to T2D were clustered in the two groups with high increasing and chronic overweight z-scores (P < 0.0001).
|
26308479 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
Notable associations observed for genes previously identified at genome-wide significance in other populations included MC4R (Pgenotyped = 4.49x10-4) for BMI and IGF2BP2 Pimputed_1000G = 2.55x10-6) for T2D.
|
25760438 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We performed a replication study in a Japanese population to evaluate the association between type 2 diabetes and 7 susceptibility loci originally identified by European genome-wide association study (GWAS) in 2012: ZMIZ1, KLHDC5, TLE1, ANKRD55, CILP2, MC4R, and BCAR1.
|
25951451 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
There is no evidence supporting an association between variants in the fat mass- and obesity-associated and melanocortin 4 receptor, and a member of the potassium voltage-gated channels genes and type 2 diabetes in the Saudi population.
|
25501231 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
When body mass index and waist circumference were further adjusted, the association of MC4R with type 2 diabetes remained significant (P = 1.81×10(-2)) and that of GNPDA2 was attenuated (P = 1.26×10(-1)), suggesting the effect of the locus including GNPDA2 on type 2 diabetes may be mediated through obesity.
|
25093408 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
MC4R rs17782313 was associated with obesity and could confer a certain susceptibility to T2D that could be independent of its pro-obesity effect.
|
24151814 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Of the 5 SNPs analyzed, POL1-nearby variant rs488846 [P=0.044], and MC4R-nearby variant rs1942872 [P=0.012] were associated with moderate risk of T2DM.
|
23727064 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Recently, 10 novel type 2 diabetes (T2D) susceptibility single nucleotide polymorphisms (SNPs) in ZMIZ1, ANK1, KLHDC5, TLE1, ANKRD55, CILP2, MC4R, BCAR1, HMG20A, and GRB14 loci were discovered in MetaboChip-genotyped populations of European ancestry.
|
23457408 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to investigate the association of FTO rs9939609 and MC4R rs17782313 with anthropometric indexes, BP, and type 2 diabetes mellitus among hypertensive patients.
|
23849767 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We investigated the association between genetic variants in FTO (rs9939609) and near MC4R (rs17782313) with obesity- and type 2 diabetes (T2DM)-related traits in a longitudinal birth cohort of 2,151 healthy individuals from the Vellore birth cohort in South India.
|
22421923 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These novel results suggest that the association of the FTO-rs9939609 and the MC4R-rs17782313 polymorphisms with type 2 diabetes depends on diet and that a high adherence to the MedDiet counteracts the genetic predisposition.
|
23130628 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
Carrying a genetic variant in BCL11A, ADAMTS9, IGF2BP2, WFS1, CDKAL1, TP53INP1, CDKN2A/B, TCF7L2, KCNQ1, HNF1A, FTO, MC4R and GCK increased the risk of T2D when assessing the Moroccan and Tunisian samples together.
|
22463974 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The greater rates of body mass accumulation and risk of type 2 diabetes before the age of 20 years in individuals with MC4R deficiency indicate that the effects of these mutations are more apparent during the active growth of childhood.
|
22106157 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
All studies that evaluated the association of at least one of the two MC4R polymorphism(s) with type 2 diabetes were included in the study.
|
22869321 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
The objective was to investigate the genetic markers related to obesity genes FTO and MC4R and the gene of type 2 diabetes mellitus TCF7L2 for their contribution to risk of stroke and transient ischemic attacks (TIA).
|
21921652 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
Common variants near melanocortin receptor 4 (MC4R) have been related to fatness and type 2 diabetes.
|
19844209 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Here, we evaluated the association of two variants (rs12970134 and rs4450508) near MC4R and a nonsynonymous (Gln241His) variant (rs3812316) in MLXIPL gene with type 2 diabetes (T2D) and obesity-related QTs in our case-control cohort (n = 1,528; 745 T2D cases and 783 controls) from a Sikh population from North India.
|
19680233 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in CDKN2A/B, CDKAL1, TCF7L2, TCF2, MC4R, and PPARG showed a nominal association with type 2 diabetes (P<or=0.05), of whom the three first would stand correction for multiple testing: CDKN2A/B rs10811661, OR: 1.26 (1.12-1.43) P = 1.8*10(-4); CDKAL1 rs10946398, OR: 1.23 (1.09-1.39); P = 7.1*10(-4), and TCF7L2 rs7903146, OR: 1.61 (1.19-2.18) P = 2.3 * 10(-3).
|
20161779 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
BEFREE |
Since the report of the MC4R knockout mouse in 1997, the field has been searching for links between this genetic biomarker and human obesity and type 2 diabetes.
|
20462274 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Prospectively, we demonstrated that each FTO and MC4R risk allele increased obesity and T2D incidences by 24% (P = 0.02) and 21% (P = 0.02), respectively.
|
19255736 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We examined rs17782313, rs17700633, rs12970134, rs477181, rs502933, and rs4450508 near MC4R for association with obesity-related quantitative traits, obesity, and type 2 diabetes in Danish individuals.
|
19073769 |
2009 |