MC4R, melanocortin 4 receptor, 4160

N. diseases: 149; N. variants: 58
Disease: Fatty Liver ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.220 GeneticVariation disease BEFREE An eight-week CANA treatment attenuated hepatic steatosis in WD-fed MC4R-KO mice, with increased epididymal fat mass without inflammatory changes. 29402900 2018
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.220 Biomarker disease BEFREE MC4R KO mice were hyperphagic, obese, hyperglycemic, hyperinsulinemic and demonstrated insulin resistance and hepatic steatosis. 28003536 2017
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.220 Biomarker disease MGD Thus, MC4R-KO mice provide a novel mouse model of NASH with which to investigate the sequence of events that make up diet-induced hepatic steatosis, liver fibrosis, and hepatocellular carcinoma and to aid in understanding the pathogenesis of NASH, pursuing specific biomarkers, and evaluating potential therapeutic strategies. 21906580 2011
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.220 Biomarker disease MGD Divergence of melanocortin pathways in the control of food intake and energy expenditure. 16269339 2005