Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.090 Biomarker group BEFREE The aim of the present work was to assess the cell proliferative activity of minichromosome maintenance protein (MCM-2) in oral epithelial dysplastic lesions and to correlate the results with different grades of epithelial dysplasia in an attempt to use MCM-2 in the early detection of malignancy. 26990745 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.090 Biomarker group BEFREE Particularly, 11 proteins involved in tumor proliferation (MCM2, 4, 6, 7, and MSH2), metastasis (RCC2, CORO1C, CHD4, and IPO9), and cancer metabolism (PHGDH and TYMP) are identified as SCLC-specific proteins. 29888431 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.090 Biomarker group BEFREE Malignancies often exhibit defective minichromosome maintenance protein 2 (MCM2), a cancer proliferation biomarker that serves as a licensing factor in the initiation of DNA replication. 29038488 2017
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.090 Biomarker group BEFREE In pancreaticobiliary cancer minichromosome maintenance replication proteins (MCM 2-7) are dysregulated in the biliary epithelium and MCM5 levels are elevated in bile samples. 28081547 2017
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.090 Biomarker group BEFREE Mice hypomorphic for MCM2-7, which activate fewer dormant origins in response to replication inhibition, are cancer-prone and are genetically unstable. 22904560 2012
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.090 AlteredExpression group BEFREE Statistical analysis of the expression of MCM2 mRNA and protein in gastric cancer and normal tissues was performed to evaluate the relationship between MCM2 expression and clinicopathological characteristics in gastric cancer. 21947329 2012
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.090 Biomarker group BEFREE In vivo, abrogating p53-mediated DDR in Mcm2-deficient mice results in increased embryonic lethality and accelerated cancer formation in surviving mice. 20440269 2010
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.090 AlteredExpression group BEFREE Correlation of Ki-67 and MCM-2 proliferative marker expression with grade of histological malignancy (G) in ductal breast cancers. 21097442 2010
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.090 Biomarker group BEFREE Increased expressions of Ki67, BM28, p53 and EGFR family members in neoplastic cells were associated with malignancy and unfavorable clinical course. 11206334 2001