Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Upregulation of BUB1B, CCNB1, CDC7, CDC20, and MCM3 in Tumor Tissues Predicted Worse Overall Survival and Disease-Free Survival in Hepatocellular Carcinoma Patients.
|
30363964 |
2018 |
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
MCM3 expression was detected in 38 (90%) tumors, and PCNA expression in 28 (67%), yet none of clinicopathological factors was related to them.
|
28493257 |
2018 |
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Our findings indicate that although both MCM3 and Ki-67 represent reliable markers of cellular proliferation in OSCC, as MCM3 expression does not appear to be influenced by external factors, this protein may emerge as a novel marker of cellular proliferation in these types of tumors.
|
27258565 |
2018 |
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
There was a statistically significant difference between SHH (p = 0.0064), STAT3 (p = 0.0003), and MCM3 (p = 0.0257) when all tumors were compared and a higher expression in parenchyma for all tumors when stroma and parenchyma were compared (p < 0.05).
|
26790448 |
2016 |
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
MCM3 expression was found to be up-regulated in glioma and correlated with overall survival in patients with WHO grade III tumor.
|
25046975 |
2014 |
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Four studies attempted to define the prognostic signature of skin melanoma but only one based the study on the primary tumor resulting in heterogenous signatures with a minimal overlap (MCM3 and NFKBIZ).
|
20177751 |
2010 |
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Nude mice who received injections of HEK 293 cells stably transfected with MCM3 formed tumors in 6 weeks.
|
15623617 |
2004 |
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
When this interface is disrupted, we note loss of stable dimer-dimer complex formation on the DNA, compromised <i>oriP</i>-containing plasmid replication in cells, and impaired recruitment of the MCM3 complex to the <i>oriP</i> Surface conservation analysis reveals that these residues are part of a larger conserved surface that may be critical for recruitment of replication machinery to the <i>oriP</i> Our results reveal a new region of EBNA1 critical for its activity and one that may be exploited by targeted small molecules to treat EBV-associated disease.<b>IMPORTANCE</b> Epstein-Barr virus (EBV) is a causative agent of various malignancies and may also contribute to autoimmune disease.
|
31142669 |
2019 |
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
The Cancer Genome Atlas data mining in the University of Alabama interactive web resource for pathways associated with poor survival of patients with adrenocortical carcinoma revealed significant upregulation of genes involved in DNA damage and regulation of cell-cycle pathways, such as AURKA, AURKB, CDK1, CDK4, CDK6, PLK1, CHEK1, CHEK2, CDC7, BUB3, and MCM3 (P < .001-.05).
|
30413320 |
2019 |
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Our study indicates that determination of MCM3 expression level will facilitate the assessment of many different human malignancies in tumor diagnosis, and MCM3 is involved in multiple types of human carcino-genesis.
|
15623617 |
2004 |
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We found DNA replication initiation protein Minichromosome Maintenance 3 (MCM3) was upregulated in HCC tissues and cells, patients with high MCM3 expression had poor outcome, it was an independent prognostic factor for HCC.
|
31208444 |
2019 |
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Overexpression of BUB1B, CCNB1, CDC7, CDC20, and MCM3 in HCC tissues accounted for poorer overall survival (OS) and disease-free survival (DFS) in HCC patients (all log rank <i>P</i> < 0.05).
|
30363964 |
2018 |
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
When this interface is disrupted, we note loss of stable dimer-dimer complex formation on the DNA, compromised <i>oriP</i>-containing plasmid replication in cells, and impaired recruitment of the MCM3 complex to the <i>oriP</i> Surface conservation analysis reveals that these residues are part of a larger conserved surface that may be critical for recruitment of replication machinery to the <i>oriP</i> Our results reveal a new region of EBNA1 critical for its activity and one that may be exploited by targeted small molecules to treat EBV-associated disease.<b>IMPORTANCE</b> Epstein-Barr virus (EBV) is a causative agent of various malignancies and may also contribute to autoimmune disease.
|
31142669 |
2019 |
Renal Cell Carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
In this study, we demonstrated that polo-like kinase 1 (PLK1)-mediated MCM3 phosphorylation regulates proliferation and apoptosis in RCC.
|
31186514 |
2019 |
Hepatitis C
|
0.010 |
Biomarker
|
disease |
BEFREE |
The patients with hepatitis B virus or hepatitis C virus infection only were combined into the HCC-V group for further analysis.
|
30755830 |
2019 |
Ovarian Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Two hub genes, MCM3 and GINS2, were significantly associated with worse overall survival of patients with OC.
|
31703725 |
2019 |
Adrenal Cortical Adenoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Specimens of 81 adrenocortical adenomas and 3 adrenocortical carcinomas were stained with antibodies against MCM-3, 5, 7 and Ki-67.
|
30842144 |
2019 |
Adrenocortical carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Specimens of 81 adrenocortical adenomas and 3 adrenocortical carcinomas were stained with antibodies against MCM-3, 5, 7 and Ki-67.
|
30842144 |
2019 |
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
In this study, we demonstrated that polo-like kinase 1 (PLK1)-mediated MCM3 phosphorylation regulates proliferation and apoptosis in RCC.
|
31186514 |
2019 |
Malignant neoplasm of ovary
|
0.010 |
Biomarker
|
disease |
BEFREE |
Two hub genes, MCM3 and GINS2, were significantly associated with worse overall survival of patients with OC.
|
31703725 |
2019 |
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
The Cancer Genome Atlas data mining in the University of Alabama interactive web resource for pathways associated with poor survival of patients with adrenocortical carcinoma revealed significant upregulation of genes involved in DNA damage and regulation of cell-cycle pathways, such as AURKA, AURKB, CDK1, CDK4, CDK6, PLK1, CHEK1, CHEK2, CDC7, BUB3, and MCM3 (P < .001-.05).
|
30413320 |
2019 |
Carcinoma, Ovarian Epithelial
|
0.010 |
Biomarker
|
disease |
BEFREE |
Two hub genes, MCM3 and GINS2, were significantly associated with worse overall survival of patients with OC.
|
31703725 |
2019 |
Squamous cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
MCM3: A Novel Proliferation Marker in Oral Squamous Cell Carcinoma.
|
27258565 |
2018 |
Diabetic Nephropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we further examined the roles of SND p102 in diabetic nephropathy (DN)-induced glomerulosclerosis.
|
30150789 |
2018 |
Glomerulosclerosis (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we further examined the roles of SND p102 in diabetic nephropathy (DN)-induced glomerulosclerosis.
|
30150789 |
2018 |