Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.070 Biomarker group BEFREE Upregulation of BUB1B, CCNB1, CDC7, CDC20, and MCM3 in Tumor Tissues Predicted Worse Overall Survival and Disease-Free Survival in Hepatocellular Carcinoma Patients. 30363964 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.070 AlteredExpression group BEFREE MCM3 expression was detected in 38 (90%) tumors, and PCNA expression in 28 (67%), yet none of clinicopathological factors was related to them. 28493257 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.070 AlteredExpression group BEFREE Our findings indicate that although both MCM3 and Ki-67 represent reliable markers of cellular proliferation in OSCC, as MCM3 expression does not appear to be influenced by external factors, this protein may emerge as a novel marker of cellular proliferation in these types of tumors. 27258565 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.070 Biomarker group BEFREE There was a statistically significant difference between SHH (p = 0.0064), STAT3 (p = 0.0003), and MCM3 (p = 0.0257) when all tumors were compared and a higher expression in parenchyma for all tumors when stroma and parenchyma were compared (p < 0.05). 26790448 2016
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.070 AlteredExpression group BEFREE MCM3 expression was found to be up-regulated in glioma and correlated with overall survival in patients with WHO grade III tumor. 25046975 2014
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.070 Biomarker group BEFREE Four studies attempted to define the prognostic signature of skin melanoma but only one based the study on the primary tumor resulting in heterogenous signatures with a minimal overlap (MCM3 and NFKBIZ). 20177751 2010
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.070 Biomarker group BEFREE Nude mice who received injections of HEK 293 cells stably transfected with MCM3 formed tumors in 6 weeks. 15623617 2004
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.030 Biomarker group BEFREE When this interface is disrupted, we note loss of stable dimer-dimer complex formation on the DNA, compromised <i>oriP</i>-containing plasmid replication in cells, and impaired recruitment of the MCM3 complex to the <i>oriP</i> Surface conservation analysis reveals that these residues are part of a larger conserved surface that may be critical for recruitment of replication machinery to the <i>oriP</i> Our results reveal a new region of EBNA1 critical for its activity and one that may be exploited by targeted small molecules to treat EBV-associated disease.<b>IMPORTANCE</b> Epstein-Barr virus (EBV) is a causative agent of various malignancies and may also contribute to autoimmune disease. 31142669 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.030 Biomarker group BEFREE The Cancer Genome Atlas data mining in the University of Alabama interactive web resource for pathways associated with poor survival of patients with adrenocortical carcinoma revealed significant upregulation of genes involved in DNA damage and regulation of cell-cycle pathways, such as AURKA, AURKB, CDK1, CDK4, CDK6, PLK1, CHEK1, CHEK2, CDC7, BUB3, and MCM3 (P < .001-.05). 30413320 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.030 Biomarker group BEFREE Our study indicates that determination of MCM3 expression level will facilitate the assessment of many different human malignancies in tumor diagnosis, and MCM3 is involved in multiple types of human carcino-genesis. 15623617 2004
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.020 AlteredExpression disease BEFREE We found DNA replication initiation protein Minichromosome Maintenance 3 (MCM3) was upregulated in HCC tissues and cells, patients with high MCM3 expression had poor outcome, it was an independent prognostic factor for HCC. 31208444 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.020 Biomarker disease BEFREE Overexpression of BUB1B, CCNB1, CDC7, CDC20, and MCM3 in HCC tissues accounted for poorer overall survival (OS) and disease-free survival (DFS) in HCC patients (all log rank <i>P</i> < 0.05). 30363964 2018
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.010 Biomarker group BEFREE When this interface is disrupted, we note loss of stable dimer-dimer complex formation on the DNA, compromised <i>oriP</i>-containing plasmid replication in cells, and impaired recruitment of the MCM3 complex to the <i>oriP</i> Surface conservation analysis reveals that these residues are part of a larger conserved surface that may be critical for recruitment of replication machinery to the <i>oriP</i> Our results reveal a new region of EBNA1 critical for its activity and one that may be exploited by targeted small molecules to treat EBV-associated disease.<b>IMPORTANCE</b> Epstein-Barr virus (EBV) is a causative agent of various malignancies and may also contribute to autoimmune disease. 31142669 2019
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma
0.010 PosttranslationalModification disease BEFREE In this study, we demonstrated that polo-like kinase 1 (PLK1)-mediated MCM3 phosphorylation regulates proliferation and apoptosis in RCC. 31186514 2019
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.010 Biomarker disease BEFREE The patients with hepatitis B virus or hepatitis C virus infection only were combined into the HCC-V group for further analysis. 30755830 2019
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.010 Biomarker disease BEFREE Two hub genes, MCM3 and GINS2, were significantly associated with worse overall survival of patients with OC. 31703725 2019
CUI: C0206667
Disease: Adrenal Cortical Adenoma
Adrenal Cortical Adenoma
0.010 Biomarker disease BEFREE Specimens of 81 adrenocortical adenomas and 3 adrenocortical carcinomas were stained with antibodies against MCM-3, 5, 7 and Ki-67. 30842144 2019
CUI: C0206686
Disease: Adrenocortical carcinoma
Adrenocortical carcinoma
0.010 Biomarker disease BEFREE Specimens of 81 adrenocortical adenomas and 3 adrenocortical carcinomas were stained with antibodies against MCM-3, 5, 7 and Ki-67. 30842144 2019
Conventional (Clear Cell) Renal Cell Carcinoma
0.010 PosttranslationalModification disease BEFREE In this study, we demonstrated that polo-like kinase 1 (PLK1)-mediated MCM3 phosphorylation regulates proliferation and apoptosis in RCC. 31186514 2019
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.010 Biomarker disease BEFREE Two hub genes, MCM3 and GINS2, were significantly associated with worse overall survival of patients with OC. 31703725 2019
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.010 Biomarker group BEFREE The Cancer Genome Atlas data mining in the University of Alabama interactive web resource for pathways associated with poor survival of patients with adrenocortical carcinoma revealed significant upregulation of genes involved in DNA damage and regulation of cell-cycle pathways, such as AURKA, AURKB, CDK1, CDK4, CDK6, PLK1, CHEK1, CHEK2, CDC7, BUB3, and MCM3 (P < .001-.05). 30413320 2019
CUI: C4721610
Disease: Carcinoma, Ovarian Epithelial
Carcinoma, Ovarian Epithelial
0.010 Biomarker disease BEFREE Two hub genes, MCM3 and GINS2, were significantly associated with worse overall survival of patients with OC. 31703725 2019
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.010 Biomarker disease BEFREE MCM3: A Novel Proliferation Marker in Oral Squamous Cell Carcinoma. 27258565 2018
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.010 Biomarker disease BEFREE In this study, we further examined the roles of SND p102 in diabetic nephropathy (DN)-induced glomerulosclerosis. 30150789 2018
CUI: C0178664
Disease: Glomerulosclerosis (disorder)
Glomerulosclerosis (disorder)
0.010 Biomarker disease BEFREE In this study, we further examined the roles of SND p102 in diabetic nephropathy (DN)-induced glomerulosclerosis. 30150789 2018