|
Ki-1+ Anaplastic Large Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Favorable outcomes and reduced toxicity with a novel vinblastine-based non-high dose methotrexate (HDMTX) regimen (modified MCP-842) in pediatric anaplastic large cell lymphoma (ALCL): experience from India.
|
31774004 |
2020 |
|
Childhood Anaplastic Large Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Favorable outcomes and reduced toxicity with a novel vinblastine-based non-high dose methotrexate (HDMTX) regimen (modified MCP-842) in pediatric anaplastic large cell lymphoma (ALCL): experience from India.
|
31774004 |
2020 |
|
Multiple Chronic Conditions
|
0.010 |
Biomarker
|
disease |
BEFREE |
Multiplex CRISPR/Cas9 gene editing and somatic cell nuclear transfer were used to generate pigs carrying functional knockouts of GGTA1, CMAH, B4GALNT2 and SLA class I. Fibroblasts derived from one- to four-fold knockout animals, and from multi-transgenic cells (human CD46, CD55, CD59, HO1 and A20) with the four-fold knockout were used to examine the effects on human IgG and IgM binding or complement activation in vitro.
|
31591751 |
2020 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In median comparison among groups, subclinical atherosclerosis showed higher serum concentrations of MCP-1and lower serum concentrations of FGF-21.
|
31152776 |
2019 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In median comparison among groups, subclinical atherosclerosis showed higher serum concentrations of MCP-1and lower serum concentrations of FGF-21.
|
31152776 |
2019 |
|
IGA Glomerulonephritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The transcriptional expression in peripheral white blood cells (WBCs) of CD46 and CD55 was investigated in 157 patients enrolled by the Validation of the Oxford Classification of IgAN group, looking for correlations with clinical and pathology features and estimated glomerular filtration rate (eGFR) modifications from renal biopsy to sampling.
|
29635535 |
2019 |
|
Heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Methods:</b> Rabbits were divided into sham, heart failure (model), MCP, and perindopril groups, respectively.
|
30967790 |
2019 |
|
Congestive heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Methods:</b> Rabbits were divided into sham, heart failure (model), MCP, and perindopril groups, respectively.
|
30967790 |
2019 |
|
Acute lymphocytic leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A total of 96 children with ALL undergoing therapy with MCP-841 protocol were screened for all the ten exons of TPMT, exon 2, exon 3 and intron 2 of ITPA using bidirectional sequencing.
|
30806759 |
2019 |
|
Synovitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
MCP joints with more severe synovitis ('bad joints') demonstrated significantly lower dGEMRIC values compared to MCP joints with less severe synovitis ('good joints') at time-points 0 and 3 months (p=0.002; p=0.019, respectively).
|
29998824 |
2019 |
|
Thalassemia
|
0.010 |
GeneticVariation
|
group |
BEFREE |
HDAd5/35++ vectors for in vivo gene therapy of thalassemia had a unique capsid that targeted primitive HSPCs through human CD46, a relatively safe SB100X transposase-based integration machinery, a micro-LCR-driven γ-globin gene, and an MGMT(P140K) system that allowed for increasing the therapeutic effect by short-term treatment with low-dose O6-benzylguanine plus bis-chloroethylnitrosourea.
|
30422819 |
2019 |
|
Polyendocrinopathies, Autoimmune
|
0.010 |
Biomarker
|
group |
BEFREE |
We found that placental DAF and CD46 decreased in β2GPI passively immunized APS model mice, accompanied by C3 deposition, neutrophil infiltration and increased proinflammatory cytokine levels detected in its placenta.
|
31091357 |
2019 |
|
Essential Tremor
|
0.010 |
Biomarker
|
disease |
BEFREE |
Significant atrophy of bilateral MCP and ICP and bilateral cerebellar GM was observed in ET.
|
31161314 |
2019 |
|
Thalassemia Intermedia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We showed in "healthy" human CD46-transgenic mice and in a mouse model of thalassemia intermedia that our in vivo approach resulted in stable γ-globin expression in the majority of circulating red blood cells.
|
30422819 |
2019 |
|
Congenital infectious disease
|
0.010 |
Biomarker
|
group |
BEFREE |
Further, we demonstrate a CD46-dependent entry pathway of virus infection in trophoblasts, but not in fibroblasts, highlighting the complexity of CMV entry and identifying CD46 as an entry factor in congenital infection.
|
31221976 |
2019 |
|
Cerebellar signs
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
This study aims to evaluate the macrostructural integrity of the superior, middle, and inferior cerebellar peduncles (SCP, MCP, ICP) and cerebellar gray and white matter (GM, WM) volumes in patients with ET, and compare these volumes between patients with and without cerebellar signs (ETc and ETnc).
|
31161314 |
2019 |
|
Adult Acute Lymphocytic Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A total of 96 children with ALL undergoing therapy with MCP-841 protocol were screened for all the ten exons of TPMT, exon 2, exon 3 and intron 2 of ITPA using bidirectional sequencing.
|
30806759 |
2019 |
|
Adenocarcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Thus, CD46 is an excellent target for antibody-based therapy development, which has potential to be applicable to both adenocarcinoma and neuroendocrine types of mCRPC that are resistant to current treatment.
|
30185663 |
2018 |
|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
CD46 induced autophagy and decreased the oxidative stress-mediated apoptosis of respiratory epithelium, and this may offer a new therapeutic strategy to treat asthma.
|
30154478 |
2018 |
|
Coronary Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Aberrant histone modifications of global histone and <i>MCP-1</i> promoter in CD14<sup>+</sup> monocytes from patients with coronary artery disease.
|
29609686 |
2018 |
|
Coronary heart disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Aberrant histone modifications of global histone and <i>MCP-1</i> promoter in CD14<sup>+</sup> monocytes from patients with coronary artery disease.
|
29609686 |
2018 |
|
External exotoses
|
0.010 |
Biomarker
|
disease |
BEFREE |
Dorsal erosions [odds ratio (OR) 4.0], osteophytes (OR 2.1) and extensor tendinitis (OR 4.6) increased the risk of underestimating inflammation of MCP and PIP joints and osteophytes (OR 3.0) also increased the risk of overestimating inflammation.
|
29471516 |
2018 |
|
Gastritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study results suggested that the prophylactic administration of MCP reduced ethanol-induced gastric injury in rats through the suppression of gastric inflammation and oxidative stress, predominantly via NF-κB inhibition.
|
29307809 |
2018 |
|
Kyphosis deformity of spine
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Focusing on the expression of the major Bicoid target, hunchback (hb), at the onset of zygotic transcription, we used the MS2-MCP approach which combines fluorescent labeling of nascent mRNA with live imaging at high spatial and temporal resolution.
|
30365533 |
2018 |
|
Parainfluenza
|
0.010 |
Biomarker
|
disease |
BEFREE |
Many viruses incorporate cellular regulators of complement activation (RCA) to block complement pathways and our prior work has shown that Parainfluenza virus 5 (PIV5) incorporates CD55 and CD46 to delay complement-mediated neutralization.
|
29693588 |
2018 |