|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Peptide-specific T cell lines recognized cells transfected with an MDK-encoded plasmid and tumor cell lines naturally expressing the MDK protein, but not untransfected cells.
|
20511550 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MDK activates the PI3K pathway and induces anti-apoptotic activity, in turn enhancing the survival of tumors.
|
23976985 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression of midkine (MK), a heparin-binding growth factor, is increased in various human tumors, making it a promising tumor marker and target for tumor therapy.
|
21787488 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
To investigate the in vivo effects of MK overexpression on tumor growth, each cell line was injected s.c. and orthotopically into nude mice.
|
14613994 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The present study was conducted to assess whether midkine (MK), a multifunctional molecule known to stimulate tumor growth, may be involved in the development of endometriosis.
|
15734764 |
2005 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Midkine is highly expressed in various cancers, including neuroblastoma, one of the most malignant paediatric solid tumours known.
|
24116381 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumors that hemorrhaged had higher IHC staining for CD34 and CD105. mRNA expression analysis revealed tumor hemorrhage was associated with increased expression of HIF1α and MDK, and decreased expression of F3.
|
28102487 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest an important role of MK in the development and/or biological behavior of tumors and raised a possibility to use MK as a diagnostic marker.
|
8383007 |
1993 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Antisense oligonucleotides targeting midkine inhibit tumor growth in an in situ human hepatocellular carcinoma model.
|
17303011 |
2007 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A significant positive correlation was observed between the expression levels of MK and the infiltrative depth of the tumor, the presence of lymph node metastasis and the prognosis of the patients (P<0.05).
|
25017879 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The cytokine midkine (MK) promotes tumor growth mainly by inducing angiogenesis.
|
22707563 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
On this basis, we replaced the CAR binding sequence of Ad5 with the CD46 binding sequence of Ad35 in the replication-defective adenoviruses and the tumor-specific midkine promoter-regulated oncolytic adenoviruses.
|
23962292 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Midkine overexpression has been shown to be a tumor biomarker in several types of human cancer, but little is known about the clinical significance of midkine in breast cancer patients.
|
26159850 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, there was exclusive or elevated in vitro expression of angiogenic factors IL-8, PDGF-AB, and, to a lesser extent, midkine in cell lines that formed highly vascularized tumors.
|
10842189 |
2000 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Midkine (MK) expression has been documented to be inversely correlated with the prognosis of patients with various tumors, but the mechanism of this relationship has not been well characterized.
|
20811700 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Using the minimal promoter region of MK to drive the HSV-TK gene and in vivo electroporation to transduce IL-21 DNA into the tumors produced an efficient gene therapy with improved safety.
|
17695518 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We showed that MDKΔ81-121 dramatically inhibited (up to 91%) tumor development and growth.
|
25492619 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Further study is necessary on the mechanism of MK in gastric tumorigenesis and tumor growth.
|
17484808 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, in in vitro and in vivo assays, knockdown of midkine resulted in significant sensitivity to anoikis, decreased cell survival and significantly decreased tumor occurrence rate.
|
28430645 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The expressions of midkine and pleiotrophin mRNA in cervical cancer were higher than those in the normal cervix (MK, 175.59 +/- 63.3 vs 1.00 +/- 0.18 fmol, respectively; PTN, 3.18 +/- 1.25 vs. 0.86 +/- 0.12 fmol, respectively, P < 0.05), and their expressions were not correlated with cervical cancer stage or size of the tumor.
|
12648577 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Therapeutic approaches targeting midkine suppress tumor growth and lung metastasis in osteosarcoma.
|
22099874 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
ALK activation was largely independent of mutations and correlated with midkine expression in tumors.
|
26687816 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
By contrast, no significant difference in cytotoxicity was detected between these viruses in normal human fibroblasts. oHSV-MDK-34.5 impaired in vivo tumor growth and increased median survival of MPNST tumor-bearing nude mice.
|
20603890 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In the noncancerous follicular epithelial cells adjacent to neoplasm the signals of MK transcripts were detected very weakly or not at all.
|
11048798 |
2000 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Patients with high tumor midkine expression frequently have a worse prognosis than those with low expression.
|
22672821 |
2012 |