Mammary Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Among homozygous carriers of the common MDM2 SNP309 allele (T/T), a mutant p53 status (risk ratio [RR] of death = 2.33, 95% CI = 1.08 to 5.03) and aberrant p53 protein expression (RR = 2.61, 95% CI = 1.22 to 5.57) in breast tumors were associated with poor survival.
|
16818855 |
2006 |
Mammary Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We investigated the effects of the germ-line single nucleotide polymorphisms TP53 R72P (215G>C) and MDM2 SNP309 (-410T>G), and p53 protein expression in breast tumors on survival.
|
20021639 |
2009 |
Mammary Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
No association between the MDM2 -309 T/G promoter polymorphism and breast cancer in African-Americans or Whites.
|
16434608 |
2006 |
Mammary Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Among homozygous carriers of the common MDM2 SNP309 allele (T/T), a mutant p53 status (risk ratio [RR] of death = 2.33, 95% CI = 1.08 to 5.03) and aberrant p53 protein expression (RR = 2.61, 95% CI = 1.22 to 5.57) in breast tumors were associated with poor survival.
|
16818855 |
2006 |
Mammary Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
MDM2 SNP309 G allele increases risk but the T allele is associated with earlier onset age of sporadic breast cancers in the Chinese population.
|
18281248 |
2008 |
Mammary Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Association of polymorphism in MDM-2 and p53 genes with breast cancer risk in Indian women.
|
17719241 |
2008 |
Mammary Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
MDM2 SNP309 is associated with high grade node positive breast tumours and is in linkage disequilibrium with a novel MDM2 intron 1 polymorphism.
|
18828900 |
2008 |
Mammary Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Results based on 124 cases of breast cancer and 97 controls from Taiwan suggest that the single nucleotide polymorphism (SNP309) in the MDM2 gene promoter is associated with earlier onset and increased risk of breast cancer.
|
19144119 |
2009 |
Mammary Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
The p53 Arg72Pro and MDM2 -309 polymorphisms and risk of breast cancer in the nurses' health studies.
|
17387621 |
2007 |
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Do MDM2 SNP309 and TP53 R72P interact in breast cancer susceptibility? A large pooled series from the breast cancer association consortium.
|
17909070 |
2007 |
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
TP53 mutations were identified in 7/36 (19%) breast tumors and HDM2 amplification in 2/30 (7%) tumors.
|
11336244 |
2001 |
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Distinct promoter usage of mdm2 gene in human breast cancer.
|
11956627 |
2002 |
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
MDM2 SNP309 is associated with high grade node positive breast tumours and is in linkage disequilibrium with a novel MDM2 intron 1 polymorphism.
|
18828900 |
2008 |
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
A total of 787 invasive breast tumors included in a clinically annotated multiethnic population-based tissue microarray (TMA) were screened utilizing commercially available antibodies to p53 and MDM2, and a newly developed monoclonal antibody recognizing MDM2-C.
|
30470976 |
2019 |
Mammary Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer.
|
26229107 |
2015 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Our data clearly show neither association between SNP309 and cancer risk, nor the responsibility of G allele for increased MDM2 or decreased of p53 protein levels in human primary breast tumors.
|
18547962 |
2008 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Here, the expression of mdm2 mRNA subsequent to phorbol 12,13-dibutyrate (PDB) or diethylstilbestrol (DES) treatment was analyzed in human breast tumor-derived GI-101A cell line.
|
12231395 |
2002 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Overexpression of MDM2 oncoprotein correlates with possession of estrogen receptor alpha and lack of MDM2 mRNA splice variants in human breast cancer.
|
11859876 |
2002 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The p60 form of MDM2 is a significant fraction of the p53-bound MDM2 protein in certain tumor cells, suggesting that it functions in the regulation of p53. p60 is also detected in breast tumors overexpressing MDM2.
|
9840926 |
1998 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Because all estrogen receptor-positive breast tumor cells had high MDM2 mRNA levels regardless of the status of their endogenous p53 protein, other factors likely influence MDM2 expression in these cells.
|
9815889 |
1995 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
MDM2 RNA expression levels were analysed in a subset of 57 breast tumours and overexpression was observed in 4/57 (7%) of the tumours.
|
8980401 |
1996 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
p53 activation in chronic radiation-treated breast cancer cells: regulation of MDM2/p14ARF.
|
14729628 |
2004 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Our findings support the hypothesis that the elevated levels of hdm2 expression reported in cancers such as ERalpha(+ve) breast tumors play an important role in the development of these tumors.
|
12750288 |
2003 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Our findings support the hypothesis that the elevated levels of hdm2 expression reported in cancers such as ERalpha(+ve) breast tumors play an important role in the development of these tumors.
|
12750288 |
2003 |
Mammary Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Our data clearly show neither association between SNP309 and cancer risk, nor the responsibility of G allele for increased MDM2 or decreased of p53 protein levels in human primary breast tumors.
|
18547962 |
2008 |