|
Social Anxiety
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Compared to participants with DS, those with FXS and RTS exhibited high levels of social anxiety but similar levels of social motivation.
|
31541420 |
2020 |
|
Channelopathies
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
An ASD "comorbidity" can have several fundamentally-distinct causal origins: it can arise due to shared genetic risk between ASD and non-ASD phenotypes (e.g., ASD and microcephaly in the context of the MECP2 mutation), as a "secondary symptom" of ASD when engendered by the same causal influence (e.g., epilepsy in channelopathies associated with ASD), due to chance co-occurrence of ASD with a causally-independent liability (e.g., ASD and diabetes), or as the late manifestation of an independent causal influence on ASD (eg, attention-deficit/hyperactivity disorder).
|
31344460 |
2020 |
|
Malignant tumor of cervix
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found that the expression levels of MBD2 and MeCP2 were significantly reduced in cervical cancer samples as detected by the analysis of MeCP2 in matched tumor-normal samples of patients with cervical cancer, indicating a reduction in a significant percentage of patients.
|
31114989 |
2019 |
|
Febrile Convulsions
|
0.010 |
Biomarker
|
disease |
BEFREE |
The incidence of febrile convulsions in children was higher during the first 2-3 days post-vaccination with RTS,S/AS01 than with control vaccine, consistent with the time window of post-vaccination febrile reactions in this study (mostly the day after vaccination).
|
31012786 |
2019 |
|
Fanconi Anemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found that MECP2 regulates the DNA repair Fanconi anemia pathway in HSCs.
|
31352003 |
2019 |
|
Atrial Septal Defects
|
0.010 |
Biomarker
|
group |
BEFREE |
ConvNetACh then successfully detected impairments in all ASD mouse models tested except in MeCP2-rescued mice.
|
31332003 |
2019 |
|
Herpes zoster disease
|
0.010 |
Biomarker
|
group |
BEFREE |
The most advanced phase III clinical applications led to the development of two vaccines containing QS-21 as part of the AS, the Herpes Zoster vaccine (HZ/su) (Shingrix™) which received a license in 2017 from the FDA and a marketing authorization in the EU in 2018 and the RTS,S/AS01 vaccine (Mosquirix™) against malaria, which was approved by the EMA in 2015 for further implementation in Sub-Saharan countries for routine use.
|
31182297 |
2019 |
|
HIV Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Molecular analysis showed that H3K27me3, Ezh2, MeCP2, and Tat all exhibited a similar bimodal expression kinetics in the course of HIV infection and latency in astrocytes, although H3K27me3, Ezh2, and MeCP2 were expressed higher in Tat-expressing astrocytes and their expression were peaked immediately preceding Tat expression.
|
31020497 |
2019 |
|
Maple Syrup Urine Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
CACNA2D2 (α2δ2 subunit of voltage-gated calcium channels) and MECP2 (methyl-CpG binding protein 2) mRNA and protein showed an excellent neural function biomarker signature (AUC ≥ 0,925) for recognition of MSUD.
|
31235756 |
2019 |
|
Post-Traumatic Stress Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Fluoxetine improved PTSD-like symptoms in trauma-exposed MeCP2-308 mice.
|
31175878 |
2019 |
|
Uterine Fibroids
|
0.010 |
Biomarker
|
group |
BEFREE |
Neither the mRNA nor the protein levels of the other MBD members (MBD1, MBD3, MBD4, MBD5, and MeCP2) showed any significant differences between ULs and the adjacent myometria.
|
31313936 |
2019 |
|
Lissencephaly
|
0.010 |
Biomarker
|
disease |
BEFREE |
Interplay of LIS1 and MeCP2: Interactions and Implications With the Neurodevelopmental Disorders Lissencephaly and Rett Syndrome.
|
31474834 |
2019 |
|
Cervix carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found that the expression levels of MBD2 and MeCP2 were significantly reduced in cervical cancer samples as detected by the analysis of MeCP2 in matched tumor-normal samples of patients with cervical cancer, indicating a reduction in a significant percentage of patients.
|
31114989 |
2019 |
|
Diabetic Cardiomyopathies
|
0.010 |
Biomarker
|
disease |
BEFREE |
MeCP2 triggers diabetic cardiomyopathy and cardiac fibroblast proliferation by inhibiting RASSF1A.
|
31398393 |
2019 |
|
Convulsion in childhood
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The incidence of febrile convulsions in children was higher during the first 2-3 days post-vaccination with RTS,S/AS01 than with control vaccine, consistent with the time window of post-vaccination febrile reactions in this study (mostly the day after vaccination).
|
31012786 |
2019 |
|
Cutaneous Mastocytosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The observed meningitis and CM signals are considered likely chance findings, that - given their severity - warrant further evaluation in phase IV studies and WHO-led pilot implementation programs to establish the RTS,S/AS01 benefit-risk profile in real-life settings.
|
31012786 |
2019 |
|
Cardiomyopathy, Familial Idiopathic
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we employed streptozotocin (STZ)-induced rats DCM and DCM patient and found that MeCP2 triggers cardiac fibroblast proliferation in DCM by inhibiting of RASSF1A expression.
|
31398393 |
2019 |
|
Surgically-Created Resection Cavity
|
0.010 |
Biomarker
|
disease |
BEFREE |
Resection cavity walls were injected (day 0) with a fixed dose of the hIL-12 vector (Ad-RTS-hIL-12).
|
31413142 |
2019 |
|
ATRIAL SEPTAL DEFECT 1
|
0.010 |
Biomarker
|
disease |
BEFREE |
ConvNetACh then successfully detected impairments in all ASD mouse models tested except in MeCP2-rescued mice.
|
31332003 |
2019 |
|
Chronic kidney disease stage 5
|
0.010 |
Biomarker
|
disease |
BEFREE |
The median age of Indigenous people who developed ESKF was ~ 30 years less than for non-Indigenous people, and 84% of them received RTT, while only half of non-Indigenous people with ESKF did so.
|
31426912 |
2019 |
|
FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found that MECP2 regulates the DNA repair Fanconi anemia pathway in HSCs.
|
31352003 |
2019 |
|
cervical cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found that the expression levels of MBD2 and MeCP2 were significantly reduced in cervical cancer samples as detected by the analysis of MeCP2 in matched tumor-normal samples of patients with cervical cancer, indicating a reduction in a significant percentage of patients.
|
31114989 |
2019 |
|
Arthritis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Considering the involvement of genetic polymorphisms of MECP2 gene in susceptibility to adult-onset RA, this gene might basically play a role in the initiation of arthritis during early stages of life.
|
29288368 |
2018 |
|
Balkan Nephropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Because modest nuclear enlargement of kidney tubule cells can occur as physiological or functional responses, it is recommended that the threshold for diagnosing renal tubule karyomegaly in animal studies should be accepted as at least four times normal nuclear size or larger.Abbreviations: BEN: Balkan Endemic Nephropathy; DMN: dimethylnitrosamine; GLP: Good Laboratory Practice; KIN: karyomegalic interstitial nephritis; LAL: lysinoalanine; MeCCNU: 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea; NTP: National Toxicology Program; OSOM: outer stripe of outer medulla; OTA: ochratoxin A; RTT: renal tubule tumor.
|
30277423 |
2018 |
|
Blast Phase
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Patients in accelerated phase CML (CML-AP) and blast phase CML (CML-BP) showed lower expressions of MEG3 and miR-147 and higher expressions of DNMT1, DNMT3B, MBD2, MECP2 and HDAC1 compared to the controls.
|
30072211 |
2018 |