|
Common Migraine
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Sixteen of the patients were carriers of the risk allele rs2274316 ( MEF2D), which confers increased risk of MO and may regulate PACAP38 expression, and 16 were non-carriers.
|
26994298 |
2017 |
|
Common Migraine
|
0.330 |
Biomarker
|
disease |
BEFREE |
MEF2D, PRDM16 and ASTN2 were also found to be associated with migraine without aura (MO) and migraine with family history.
|
28058730 |
2017 |
|
Common Migraine
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Conclusion Migraine response to PACAP38 infusion in migraine without aura patients is not associated with high family load or the risk allele of rs2274316 ( MEF2D).
|
26994299 |
2017 |
|
Common Migraine
|
0.330 |
Biomarker
|
disease |
CTD_human |
Genome-wide association analysis identifies susceptibility loci for migraine without aura.
|
22683712 |
2012 |
|
Migraine Disorders
|
0.130 |
GeneticVariation
|
group |
BEFREE |
Conclusion Migraine response to PACAP38 infusion in migraine without aura patients is not associated with high family load or the risk allele of rs2274316 ( MEF2D).
|
26994299 |
2017 |
|
Migraine Disorders
|
0.130 |
Biomarker
|
group |
BEFREE |
And, MEF2D and ASTN2 also served as genetic risk factors for the migraine without family history.
|
28058730 |
2017 |
|
Migraine Disorders
|
0.130 |
GeneticVariation
|
group |
GWASCAT |
Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.
|
27322543 |
2016 |
|
Migraine Disorders
|
0.130 |
GeneticVariation
|
group |
GWASCAT |
Detection and interpretation of shared genetic influences on 42 human traits.
|
27182965 |
2016 |
|
Migraine Disorders
|
0.130 |
GeneticVariation
|
group |
BEFREE |
At one extreme, SNPs rs6790925 (near TGFBR2) and rs2274316 (MEF2D) were not associated with migraine overall, MA, or MO but were selective for migraine sub-classified by the presence of one or more of the additional migraine features.
|
24852292 |
2014 |
|
Migraine Disorders
|
0.130 |
GeneticVariation
|
group |
GWASDB |
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
|
23793025 |
2013 |
|
Migraine Disorders
|
0.130 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
|
23793025 |
2013 |
|
Migraine Disorders
|
0.130 |
GeneticVariation
|
group |
GWASDB |
Genome-wide association analysis identifies susceptibility loci for migraine without aura.
|
22683712 |
2012 |
|
Migraine Disorders
|
0.130 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide association analysis identifies susceptibility loci for migraine without aura.
|
22683712 |
2012 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Body mass index
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
|
30239722 |
2019 |
|
Headache
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A Genome-Wide Association Study Finds Genetic Associations with Broadly-Defined Headache in UK Biobank (N=223,773).
|
29397368 |
2018 |
|
Platelet Count measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
RESTING HEART RATE
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Identification of genomic loci associated with resting heart rate and shared genetic predictors with all-cause mortality.
|
27798624 |
2016 |
|
White Blood Cell Count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT).
|
21738479 |
2011 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Immunohistochemistry analysis of tumor sections of 402 OC patients revealed that MEF2D is significantly elevated at the protein level.
|
31218100 |
2019 |
|
Tumor Cell Invasion
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
Mechanistic study via ChIP analysis identified two of MEF2D-targeted genes, HPSE and IKBKE, which are associated with tumor invasion and chemotherapy-resistance, in accord with MEF2D expression in OC.
|
31218100 |
2019 |
|
Tumor Cell Invasion
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
The co-transfection with pcDNA-EPIC1 and pcDNA-MEF2D rescued the inhibition of cell viability and invasion caused by the overexpression of EPIC1.
|
30703420 |
2019 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Factors secreted by RENCA macrobeads significantly up-regulated the activity of the MEF2 transcription factor as well as altered the transcription of MEF2b and MEF2d isoforms in targeted tumor cells.
|
30514247 |
2018 |
|
Tumor Cell Invasion
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
Overexpression of MEF2D results in cytotrophoblast proliferation and enhances the invasion and migration of extravillous-like HTR8/SVneo cells.
|
29127222 |
2018 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Our results revealed that the expression of MEF2D was increased in pancreatic cancer tissues compared to adjacent normal tissues and the increased expression of MEF2D was associated with tumor size, histological differentiation, and TNM stage of pancreatic cancer patients.
|
29218083 |
2017 |