Mechanistic study via ChIP analysis identified two of MEF2D-targeted genes, HPSE and IKBKE, which are associated with tumor invasion and chemotherapy-resistance, in accord with MEF2D expression in OC.
Furthermore, immunohistochemical analysis on the tissue samples obtained from 260 patients with gastric cancer revealed that MEF2D expression was significantly associated with the clinical stage, vascular invasion, metastasis, and tumor size.
To explore the molecular mechanism by which lung cancer progresses, we employed multidisciplinary approaches and used lung cancer cell lines as research models. miR-1244 was underexpressed in lung carcinoma by 40.6-73.8%, which is highly associated with patients' survival. miR-1244 restoration was shown to affect the proliferation, survival, and invasion of lung cancer cells. miR-1244 suppression rendered normal lung fibroblasts with malignant phenotypes. miR-1244 overexpression can reduce the growth of lung cancer xenografts. miR-1244 was then verified to negatively regulate the expression of myocyte enhancer factor 2D (MEF2D) in lung cancer cells.