MEIS1, Meis homeobox 1, 4211

N. diseases: 104; N. variants: 19
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome 		0.500 Biomarker disease BEFREE MEIS1 and LBXCOR1 are developmental factors and raise new pathophysiologic questions for RLS. 18541116 2008
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome 		0.500 GeneticVariation disease GWASCAT MEIS1 has been implicated in limb development, raising the possibility that RLS has components of a developmental disorder. 17637780 2007
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome 		0.500 Biomarker disease BEFREE MEIS1 has been implicated in limb development, raising the possibility that RLS has components of a developmental disorder. 17637780 2007
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome 		0.500 Biomarker disease CTD_human MEIS1 has been implicated in limb development, raising the possibility that RLS has components of a developmental disorder. 17637780 2007
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome 		0.500 GeneticVariation disease GWASDB MEIS1 has been implicated in limb development, raising the possibility that RLS has components of a developmental disorder. 17637780 2007
CUI: C0021603
Disease: Sleep Initiation and Maintenance Disorders
Sleep Initiation and Maintenance Disorders 		0.400 GeneticVariation disease GWASCAT Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits. 28604731 2017
CUI: C0021603
Disease: Sleep Initiation and Maintenance Disorders
Sleep Initiation and Maintenance Disorders 		0.400 Biomarker disease CTD_human Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits. 28604731 2017
CUI: C0917801
Disease: Sleeplessness
Sleeplessness 		0.330 GeneticVariation phenotype BEFREE While the identified genetic variation in the MEIS1 gene was previously associated with RLS, the two GWAS suggest a novel and independent association with insomnia symptoms. 30215811 2018
CUI: C0917801
Disease: Sleeplessness
Sleeplessness 		0.330 GeneticVariation phenotype BEFREE We discover loci associated with insomnia symptoms (near MEIS1, TMEM132E, CYCL1 and TGFBI in females and WDR27 in males), excessive daytime sleepiness (near AR-OPHN1) and a composite sleep trait (near PATJ (INADL) and HCRTR2) and replicate a locus associated with sleep duration (at PAX8). 27992416 2017
CUI: C0917801
Disease: Sleeplessness
Sleeplessness 		0.330 Biomarker phenotype CTD_human Additional analyses favor the hypothesis that MEIS1 exhibits pleiotropy for insomnia and RLS and show that the observed association with insomnia complaints cannot be explained only by the presence of an RLS subgroup within the cases. 28604731 2017
CUI: C0917801
Disease: Sleeplessness
Sleeplessness 		0.330 Biomarker phenotype BEFREE Additional analyses favor the hypothesis that MEIS1 exhibits pleiotropy for insomnia and RLS and show that the observed association with insomnia complaints cannot be explained only by the presence of an RLS subgroup within the cases. 28604731 2017
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.320 Biomarker disease CTD_human Our results suggest that TMEM25, REPS2 and Meis 1 mRNAs may be useful members of a panel of favourable prognostic and predictive markers for breast cancer and an understanding of their function may provide useful information about this disease. 19776672 2009
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.320 AlteredExpression disease BEFREE Our results suggest that TMEM25, REPS2 and Meis 1 mRNAs may be useful members of a panel of favourable prognostic and predictive markers for breast cancer and an understanding of their function may provide useful information about this disease. 19776672 2009
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.320 AlteredExpression disease BEFREE Our results suggest that TMEM25, REPS2 and Meis 1 mRNAs may be useful members of a panel of favourable prognostic and predictive markers for breast cancer and an understanding of their function may provide useful information about this disease. 19776672 2009
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.320 Biomarker disease CTD_human Our results suggest that TMEM25, REPS2 and Meis 1 mRNAs may be useful members of a panel of favourable prognostic and predictive markers for breast cancer and an understanding of their function may provide useful information about this disease. 19776672 2009
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.320 Biomarker disease BEFREE Utilising quantitative real-time RT-PCR assays, the expression of 20 HOX genes and two known HOX co-factors, PBX1B and MEIS1, were analysed in human melanoma and breast cancer cell lines, comparing results against non-malignant cells. 14614318 2004
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.320 Biomarker disease BEFREE Utilising quantitative real-time RT-PCR assays, the expression of 20 HOX genes and two known HOX co-factors, PBX1B and MEIS1, were analysed in human melanoma and breast cancer cell lines, comparing results against non-malignant cells. 14614318 2004
CUI: C0751249
Disease: Chronic Insomnia
Chronic Insomnia 		0.310 Biomarker disease BEFREE In conclusion, our data confirms that MEIS1 is a genetic risk factor for the development of RLS, but it does not support the pleiotropic effect of MEIS1 in CID. 30215811 2018
CUI: C0751249
Disease: Chronic Insomnia
Chronic Insomnia 		0.310 Biomarker disease CTD_human Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits. 28604731 2017
CUI: C0033139
Disease: Primary Insomnia
Primary Insomnia 		0.300 Biomarker disease CTD_human Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits. 28604731 2017
CUI: C0270541
Disease: Rebound Insomnia
Rebound Insomnia 		0.300 Biomarker phenotype CTD_human Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits. 28604731 2017
CUI: C0349255
Disease: Nonorganic Insomnia
Nonorganic Insomnia 		0.300 Biomarker disease CTD_human Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits. 28604731 2017
CUI: C0393759
Disease: Transient Insomnia
Transient Insomnia 		0.300 Biomarker phenotype CTD_human Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits. 28604731 2017
CUI: C0541798
Disease: Early Awakening
Early Awakening 		0.300 Biomarker phenotype CTD_human Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits. 28604731 2017
CUI: C0751250
Disease: Psychophysiological Insomnia
Psychophysiological Insomnia 		0.300 Biomarker disease CTD_human Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits. 28604731 2017