Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our results suggest a role for Ednra in Hoxa9/Meis1-driven leukemogenesis.
|
30384975 |
2018 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic deletion of MLL3/MLL4 blocks histone H3K4 methylation at de novo enhancers and inhibits HOXA9/MEIS1-mediated leukemogenesis in vivo.
|
30270123 |
2018 |
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In knockout mice, loss of miR-193b cooperated with Hoxa9/Meis1 during leukemogenesis, whereas restoring miR-193b expression impaired leukemic engraftment.
|
29432078 |
2018 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
PPM1K Regulates Hematopoiesis and Leukemogenesis through CDC20-Mediated Ubiquitination of MEIS1 and p21.
|
29719258 |
2018 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hoxa9 and Meis1 also cooperate to induce aggressive AML with high Flt3 expression in mice, suggesting an important role for Flt3 in Hoxa9/Meis1-induced leukemogenesis.
|
27617578 |
2017 |
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The transcription factor Meis1 drives myeloid leukemogenesis in the context of Hox gene overexpression but is currently considered undruggable.
|
28399410 |
2017 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we provide evidence of phenotypic and functional hierarchy in MN1-induced leukemic cells, characterise contributions of Hlf, Hoxa9 and Meis1 to in vitro leukemic properties, and reveal Meis2 as a novel player in MN1-induced leukemogenesis.
|
28960191 |
2017 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Aberrant fusion proteins involving the MLL histone methyltransferase (HMT) lead to recruitment of DOT1L, to a multi-protein complex resulting in aberrant methylation of histone H3 lysine 79 at MLL target genes, and ultimately enhanced expression of critical genes for hematopoietic differentiation, including HOXA9 and MEIS1, and as such defines the established mechanism for leukemogenesis in MLL-rearrangement (MLL-r) leukemias.
|
28229434 |
2017 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We analyzed global DNA binding of MEIS1 in leukemic cells as well as gene expression alterations in MEIS1-deficent cells and identified synaptotagmin-like 1 (Sytl1, also known as Slp1) as the MEIS1 target gene that cooperates with Hoxa9 in leukemogenesis.
|
27018596 |
2016 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collectively, our studies strongly implicate the PBX3/MEIS1 interaction as a driver of cell transformation and leukemogenesis, and suggest that this axis may play a critical role in the regulation of the core transcriptional programs activated in MLL-rearranged and HOX-overexpressing AML.
|
26747896 |
2016 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Homeobox genes HOXA9 and MEIS1 are evolutionarily conserved transcription factors with essential roles in both hematopoiesis and leukemogenesis.
|
26059450 |
2015 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the current study, we identified Hoxa7, Hoxa9 and Hox cofactor Meis1 as AP-2α target genes, which are involved in myeloid leukemogenesis.
|
23660297 |
2013 |
Leukemogenesis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Forced expression of miR-196b significantly delays MLL-fusion-mediated leukemogenesis in primary bone marrow transplantation through suppressing Hoxa9/Meis1 expression.
|
22353710 |
2012 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These include upregulation of genes involved in the transforming growth factorbeta pathway, fetal hemoglobin genes, leptin receptor, sorcin, tissue inhibitor of metalloproteinase 1, the neuroepithelial cell transforming gene 1 and downregulation of selenoprotein P. Additionally, genes associated with early hematopoietic stem cells (HSC) and leukemogenesis such as HoxA9 and MEIS1 were transcriptionally activated.
|
17252012 |
2007 |
Leukemogenesis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The resulting MLL fusion proteins enforce high-level expression of HOX genes and the HOX cofactor MEIS1, which is pivotal for leukemogenesis.
|
17671196 |
2007 |