RAB8A, RAB8A, member RAS oncogene family, 4218

N. diseases: 69; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.080 GeneticVariation group BEFREE The human MEL gene has been localized to 19cen-p13.2, a region in which translocation breakpoints occur in a number of malignancies. 1886711 1991
CUI: C0333516
Disease: Tumor necrosis
Tumor necrosis 		0.020 Biomarker phenotype BEFREE We measured the binding of 3H-labeled phorbol dibutyrate to membrane and cytosol fractions of TNF-treated SK-MEL-109 cells and found a transient redistribution of 3H-labeled phorbol dibutyrate binding from cytosol to membrane fractions in response to TNF. 2324095 1990
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.010 Biomarker phenotype BEFREE The latter included the melanoma cell line MeWo and its metastatic variant MeM 50-10, which display differential susceptibility to modulation of HLA class-II antigens by IFN-gamma and the cell lines SK-MEL-93-DX-2 and SK-MEL-93-DX-3, which originated from anatomically distinct metastases in patient DX. 2506138 1989
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.010 Biomarker group BEFREE The latter included the melanoma cell line MeWo and its metastatic variant MeM 50-10, which display differential susceptibility to modulation of HLA class-II antigens by IFN-gamma and the cell lines SK-MEL-93-DX-2 and SK-MEL-93-DX-3, which originated from anatomically distinct metastases in patient DX. 2506138 1989
CUI: C0023440
Disease: Acute Erythroblastic Leukemia
Acute Erythroblastic Leukemia 		0.070 GeneticVariation disease BEFREE Murine erythroleukemia (MEL or Friend) cells grown in culture and induced to differentiate into cells resembling orthochromatic normoblasts provide a suitable system for uncovering molecular and cellular mechanisms of hemopoiesis and for understanding globin gene regulation. 3888045 1985
CUI: C2347748
Disease: Adult Erythroleukemia
Adult Erythroleukemia 		0.060 GeneticVariation disease BEFREE Murine erythroleukemia (MEL or Friend) cells grown in culture and induced to differentiate into cells resembling orthochromatic normoblasts provide a suitable system for uncovering molecular and cellular mechanisms of hemopoiesis and for understanding globin gene regulation. 3888045 1985
CUI: C4520840
Disease: Erythroleukemia (Erythroid/Myeloid)
Erythroleukemia (Erythroid/Myeloid) 		0.060 GeneticVariation disease BEFREE Murine erythroleukemia (MEL or Friend) cells grown in culture and induced to differentiate into cells resembling orthochromatic normoblasts provide a suitable system for uncovering molecular and cellular mechanisms of hemopoiesis and for understanding globin gene regulation. 3888045 1985
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker disease BEFREE Human melanoma MZ2-MEL expresses several distinct antigens that are recognized by autologous cytolytic T lymphocytes (CTL). 7544395 1995
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE A similar growth-inhibitory effect of AdCMV.p53 was observed with SK-MEL-24 tumors. 7591284 1995
CUI: C0023440
Disease: Acute Erythroblastic Leukemia
Acute Erythroblastic Leukemia 		0.070 Biomarker disease BEFREE In mouse MEL erythroleukemia cells, p16INK4a associates preferentially with cdk6 under conditions where cdk4 and cdk6 are coexpressed at equivalent levels. 7651726 1995
CUI: C2347748
Disease: Adult Erythroleukemia
Adult Erythroleukemia 		0.060 Biomarker disease BEFREE In mouse MEL erythroleukemia cells, p16INK4a associates preferentially with cdk6 under conditions where cdk4 and cdk6 are coexpressed at equivalent levels. 7651726 1995
CUI: C4520840
Disease: Erythroleukemia (Erythroid/Myeloid)
Erythroleukemia (Erythroid/Myeloid) 		0.060 Biomarker disease BEFREE In mouse MEL erythroleukemia cells, p16INK4a associates preferentially with cdk6 under conditions where cdk4 and cdk6 are coexpressed at equivalent levels. 7651726 1995
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE Several tumor antigens are recognized by autologous cytolytic T lymphocytes (CTL) on human melanoma MZ2-MEL. 7895173 1995
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker disease BEFREE Using melanotic cells (SK-MEL-23 and G361) and amelanotic cells (C32 and SK-MEL-24) of human melanoma, this study examined whether UV-B irradiation has a direct stimulatory effect on the expression of genes involved in melanogenesis. 8151127 1994
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker disease BEFREE The guanosine deletion in B2m gene was detected also in the melanoma tissue from which SK-MEL-33 cells had originated. 8432869 1993
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.020 GeneticVariation phenotype BEFREE Therefore, the molecular lesion identified in the SK-MEL-33 melanoma cell line is not caused by a mutation acquired during growth in vitro but is likely to reflect a somatic mutation during tumor progression. 8432869 1993
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE However, overall production of TNF was > 30-fold lower, compared with a transduced and highly selected tumor cell line control (MEL-TNF). 8473752 1993
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker disease BEFREE Human melanoma SK-MEL-2 cells best fit these criteria and formed small, poorly vascularized tumors in immunodeficient mice. 8548760 1996
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE Human melanoma SK-MEL-2 cells best fit these criteria and formed small, poorly vascularized tumors in immunodeficient mice. 8548760 1996
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.020 Biomarker phenotype BEFREE MEL-P constitutes a valuable model for the study of multistep tumour progression and the role of biologically active GM-CSF production in human malignant melanoma. 8819123 1996
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression disease BEFREE By Northern analysis, we demonstrate that MTf mRNA is detected at various levels in melanoma SK-MEL-28 cells and that its greatest expression coincides with the presence of large amounts of jun and fos transcripts. 8836133 1996
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression disease BEFREE The current work shows that the human melanoma cell lines IIB-MEL-LES, IIB-MEL-IAN, and IIB-MEL-J and different human metastatic melanomas expressed high levels of SPARC mRNA and protein. 9008236 1997
CUI: C4725861
Disease: Metastatic Malignant Neoplasm in the Viscera
Metastatic Malignant Neoplasm in the Viscera 		0.010 AlteredExpression disease BEFREE Although no significant statistical difference was observed between in vivo growth of EGFR-positive cell lines versus EGFR-negative cell lines, UISO MEL-6 which also lacked p53 expression, had the fastest in vivo rate of growth and was the only cell line to produce visceral metastases following subcutaneous inoculation in nude mice. 9042221 1997
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression disease BEFREE In the present study, overexpression of p53 in human melanoma SK-MEL-110 cells through use of an adenoviral expression vector (AdCMV.p53) was found to result in apoptosis, while similar infection of primary vascular smooth muscle cells (VSMC) instead resulted in a moderate inhibition of growth. 9050992 1997
CUI: C0023440
Disease: Acute Erythroblastic Leukemia
Acute Erythroblastic Leukemia 		0.070 Biomarker disease BEFREE In non-B cells (murine erythroleukemia cells [MEL]), previous studies of segments within the mouse Igh locus demonstrated that DNA replication likely initiated downstream of the Igh gene cluster. 9315677 1997