|
Rheumatoid Arthritis
|
0.300 |
Biomarker
|
disease |
CTD_human |
From transcriptome to proteome: differentially expressed proteins identified in synovial tissue of patients suffering from rheumatoid arthritis and osteoarthritis by an initial screen with a panel of 791 antibodies.
|
12833524 |
2003 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The cytotoxicity of the cyclopalladated compounds has been evaluated against a panel of murine {mammary carcinoma (4T1) and melanoma (B16F10-Nex2)} and human {melanoma (A2058, SK-MEL-110 and SK-MEL-5) tumor cell lines.
|
31794895 |
2020 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among them, Il, with the solubility of 0.107 mg/mL, demonstrated favorable cellular activity against vemurafenib-resistant carcinoma cells including BRaf<sup>WT</sup> phenotypic melanoma SK-MEL-2 and BRaf<sup>V600E</sup> phenotypic colorectal cancer HT-29 cell lines.
|
30529543 |
2019 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
SK-MEL-5 is a human melanoma cell line that has been used in various studies to explore new therapies against melanoma in different <i>in vitro</i> experiments.
|
31007759 |
2019 |
|
melanoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Among them, compound <b>29</b> showed GI<sub>50</sub> (50% growth inhibition) values ranging from 0.3 to 0.9 μM against 26 different tumor cell lines and selectivity for one colon (COLO 205) and two melanoma (SK-MEL-5 and UACC-257) cell lines at the TGI (total growth inhibition) level.
|
31343174 |
2019 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Five cell lines, including one normal human primary epidermal melanocytes and two human malignant melanoma (A375, G361) and two human metastatic melanoma (A2058, SK-MEL-3) cell lines, were chosen for this research.
|
30881453 |
2019 |
|
melanoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The expression of tissue factor was investigated after the treatment with the BRAF inhibitor Dabrafenib and the MEK inhibitor Trametinib in the BRAF<sup>v600e</sup> mutated melanoma cell lines A-375 and SK-MEL-28, together with its ability to activate the coagulation cascade.
|
31467489 |
2019 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Application of microwave-irradiation technique in deglycosylation of ginsenosides for improving apoptosis induction in human melanoma SK-MEL-2 cells.
|
30594431 |
2019 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that doxorubicin (0.5-5 μmol/L) induced pyroptosis in melanoma cell lines SK-MEL-5, SK-MEL-28, and A-375 with high expression of DFNA5, but not in human breast cancer cell line MCF-7 with little expression of DFNA5.
|
30914761 |
2019 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
FEPS inhibited mushroom tyrosinase with the half maximal inhibitory concentration (IC<sub>50</sub>) of 16.5 mg/ml and dose-dependently inhibited cellular tyrosinase activity (63.9% at 50 μg/ml, and 83.3% at 100 μg/ml) in the cell-free extract of SK-MEL-5 human melanoma cell and α-melanocytestimulating hormone (α-MSH)-stimulated melanin formation in intact SK-MEL-5 human melanoma cell.
|
31336432 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Murine B16BL6 tumor are highly pigmented with mostly eumelanin (98.1% of eumelanin) while human SK-MEL-3 tumor contain about 30% pheomelanin.
|
30897406 |
2019 |
|
Red cell distribution width determination
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Finding of Mean Corpuscular Hemoglobin
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
RDW - Red blood cell distribution width result
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, we found that overexpression of snail significantly increased the mRNA and protein expression levels of FAPα in malignant melanoma B16 and SK-MEL-28 cells.
|
29410133 |
2018 |
|
melanoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The cancer cell lines used in this research work are SK-MEL-2 (melanoma), MCF-7 (breast cancer), IMR-32 (neuroblastoma) MG-63 (human osteosarcoma), HT-29 (human colon cancer) and Hep-G2 (human hepatoma).
|
30096835 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The synthesized compounds 6(a-j) were appraised for their in vitro anticancer activity against human cancer cell lines such as SK-MEL-2 (melanoma), IMR-32 (Neuroblastoma), HT-29(Colon) and also on normal murine embryonic fibroblast NIH/3T3 by Sulforhodamine B (SRB) assay, using Adriamycin as a standard drug.
|
29667556 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
[<sup>18</sup>F]MEL-2F is a new, potential analogue PET-probe for melanoma imaging.
|
29227835 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
SOX4 was knocked down using a lentivirus in melanoma A2058 and SK-MEL-5 cell lines.
|
29767266 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Treatment of B16F10 mouse and SK-MEL-5 human melanoma cell lines with 10 μM of endoxifen for 48 h respectively resulted in 93.6 and 92.5% cell death.
|
29308069 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This effect was also observed, at a lesser extent, on human melanoma IGR-39 and SK-MEL-28 cell lines.
|
29635896 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Analogs bearing substituted phenyl ring attached to oxadiazole ring 14a showed the greatest inhibitory activities against non-small-cell lung cancer NCI-H522 and melanoma SK-MEL-2 with inhibition percent of 48.70 and 42.62, respectively.
|
29431476 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We demonstrated that QS-13 binds to SK-MEL-28 melanoma cells through the α<sub>v</sub>β<sub>3</sub> integrin using blocking antibody and β3 integrin subunit siRNAs strategies.
|
29959360 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Oral administration of JTC801 inhibited growth of xenograft tumors (from PANC1, MiaPaCa2, SK-MEL-28, PC-3, 786-0, SF-295, HCT116, OV-CAR3, and HuH7 cells), orthotropic tumors (from KPC cells), lung metastases (from KPC cells) of mice, and slowed growth of tumors in KCH mice.
|
29248440 |
2018 |
|
Finding of Mean Corpuscular Hemoglobin
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.
|
29403010 |
2018 |