MEST, mesoderm specific transcript, 4232

N. diseases: 59; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0175693
Disease: Russell-Silver syndrome
Russell-Silver syndrome 		0.060 GeneticVariation disease BEFREE However, several observations indicate that molecular alterations of the genomically imprinted MEST region in 7q32.2 are associated with growth retardation and a phenotype reminiscent to SRS. 26663145 2016
CUI: C0175693
Disease: Russell-Silver syndrome
Russell-Silver syndrome 		0.060 GeneticVariation disease BEFREE Silver-Russell syndrome in a girl born after in vitro fertilization: partial hypermethylation at the differentially methylated region of PEG1/MEST. 17450433 2007
CUI: C0175693
Disease: Russell-Silver syndrome
Russell-Silver syndrome 		0.060 Biomarker disease BEFREE As a Silver-Russell syndrome (SRS) locus has been proposed to be located to a region near MEST and to be involved in imprinting, CPA4 would have been a candidate gene for SRS. 12552318 2003
CUI: C0175693
Disease: Russell-Silver syndrome
Russell-Silver syndrome 		0.060 Biomarker disease BEFREE These findings suggest that PEG1/MEST can be excluded as a major determinant of SRS. 11754049 2001
CUI: C0175693
Disease: Russell-Silver syndrome
Russell-Silver syndrome 		0.060 Biomarker disease BEFREE These findings strongly argue against a role of PEG1/MEST in the majority of Silver-Russell syndrome cases. 9781054 1998
CUI: C0175693
Disease: Russell-Silver syndrome
Russell-Silver syndrome 		0.060 GeneticVariation disease BEFREE The exclusion of isolated imprinting defects in our study population shows that this type of epimutation at the PEG1/MEST locus in 7q31 does not play a relevant role in SRS. 18585117 2008
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.040 PosttranslationalModification group BEFREE The levels of miR-335/MEST methylation were significantly higher in 18 (90%) out of 20 primary HCC tumors, compared to their non-tumor tissue counterparts (P<0.001). 23229728 2013
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.040 Biomarker group BEFREE Profiling MEST and RXRγ for curcumin and CBB1007, respectively, indicated an inability of curcumin and CBB1007 in restricting residual tumor regenerative capabilities. 26130461 2015
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.040 Biomarker group BEFREE LOI of IGF2 and PEG1/MEST was also observed in colorectal mucosa from almost all the patients with LOI in tumor tissue. 10891541 2000
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.040 AlteredExpression group BEFREE Furthermore, overexpression of MEST could restore the tumour-suppressed and the Wnt/β-catenin pathway inactivated effects of ZFP57. 30787268 2019
CUI: C0028754
Disease: Obesity
Obesity 		0.040 Biomarker disease BEFREE Since inactivation of Mest in mice has minimal additional effects aside from reduction of ATE, an intervention that mitigates MEST function in adipocytes is a plausible strategy to obviate obesity and type-2-diabetes. 28640866 2017
CUI: C0028754
Disease: Obesity
Obesity 		0.040 Biomarker disease BEFREE Highly variable expression of mesoderm-specific transcript (Mest) in adipose tissue among genetically homogeneous mice fed an obesogenic diet, and its positive association with fat mass expansion, suggests that Mest is an epigenetic determinant for the development of obesity. 29058774 2018
CUI: C0028754
Disease: Obesity
Obesity 		0.040 Biomarker disease BEFREE Specifically, epigenetic malprogramming of MEST may contribute to obesity predisposition throughout life. 23209187 2013
CUI: C0028754
Disease: Obesity
Obesity 		0.040 Biomarker disease BEFREE Peg1/Mest in obese adipose tissue is expressed from the paternal allele in an isoform-specific manner. 17182038 2007
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		0.040 Biomarker disease BEFREE Putative loss of imprinting (LOI) of PEG1/MEST has subsequently also been implicated in the aetiology of lung adenocarcinomas and colon cancer. 12023987 2002
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		0.040 Biomarker disease BEFREE These findings indicated that independent deregulation took place in imprinted genes and suggested that aberrant imprinting of IGF2 and MEST was involved in the development of lung adenocarcinoma. 11536368 2001
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		0.040 AlteredExpression disease BEFREE Taking advantage of our previous study identifying lung adenocarcinomas displaying biallelic expression of the imprinted gene MEST, we investigated the validity of a method of allelic discrimination in a real-time PCR assay using allele-specific probes. 12851725 2003
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		0.040 Biomarker disease BEFREE Recently, frequent loss of imprinting (LOI) of PEG1/MEST has been reported in lung adenocarcinomas. 15547750 2004
CUI: C0021364
Disease: Male infertility
Male infertility 		0.030 GeneticVariation phenotype BEFREE Analysis of three maternally imprinted genes (LIT1, SNRPN, MEST), two paternally imprinted genes (MEG3, H19), two repetitive elements (ALU, LINE1), one spermatogenesis-specific gene (VASA) and one gene associated with male infertility (MTHFR) in semen samples demonstrated no alteration in methylation pattern regardless of duration of cryopreservation. 22692281 2012
CUI: C0021364
Disease: Male infertility
Male infertility 		0.030 Biomarker phenotype BEFREE We conclude that idiopathic male infertility is strongly associated with imprinting defects at IGF2/H19 ICR1 and MEST, with aberrant MEST methylation being a strong indicator for sperm quality. 19878521 2010
CUI: C0021364
Disease: Male infertility
Male infertility 		0.030 PosttranslationalModification phenotype BEFREE The meta-analytic approach demonstrated that male infertility is associated with altered sperm methylation at H19, MEST, and SNRPN. 28718528 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.030 Biomarker disease BEFREE Also, MEST induces metastatic potential of breast cancer through induction of the EMT-TFs-mediated EMT program. 30903102 2019
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.030 AlteredExpression disease BEFREE In this study, we show monoallelic PEG1 expression in normal breast tissue, indicating the presence of a functional imprint, and more importantly, we demonstrate loss of imprinting (LOI) in all of seven informative invasive breast carcinomas. 10554015 1999
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.030 Biomarker disease BEFREE ZFP57-MEST and the Wnt/β-catenin pathway axis are involved in breast tumorigenesis, which may represent a potential diagnostic biomarker, and provide a new insight into a novel therapeutic strategy for breast cancer patients. 30787268 2019
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.020 Biomarker disease BEFREE Also, MEST induces metastatic potential of breast cancer through induction of the EMT-TFs-mediated EMT program. 30903102 2019