Autistic Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Additionally, given that MET is classified as a high confidence autism risk gene, the data suggest that projection neuron subpopulations may be differentially vulnerable to disorder-associated genetic variation.
|
29190358 |
2019 |
Autistic Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
We discovered that the intracellular signaling cascade requires activation of the receptor tyrosine kinase MET, which is a well known autism risk factor.
|
30914448 |
2019 |
Autistic Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Control of cortical synapse development and plasticity by MET receptor tyrosine kinase, a genetic risk factor for autism.
|
31746037 |
2019 |
Autistic Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The Pleiotropic MET Receptor Network: Circuit Development and the Neural-Medical Interface of Autism.
|
27837921 |
2017 |
Autistic Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Proteomics in three independent developing neocortical synaptosomal preparations identified putative interacting proteins of the ligand-activated MET receptor tyrosine kinase, an autism risk gene that mediates synapse development.
|
27086544 |
2016 |
Autistic Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Implication of MET in normal and pathological brain development opens new perspectives for understanding the pathophysiology of autism and for eventual therapeutical clues.
|
24909855 |
2014 |
Autistic Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Unlike many autism risk genes that encode synaptic proteins, the spatial and temporal expression pattern of MET RTK indicates this signaling system is ideally situated to regulate neuronal growth, functional maturation, and establishment of functional brain circuits, particularly in those brain structures involved in higher levels of cognition, social skills, and executive functions.
|
24290385 |
2013 |
Autistic Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Transcriptional regulation of the MET receptor tyrosine kinase gene by MeCP2 and sex-specific expression in autism and Rett syndrome.
|
24150225 |
2013 |
Autistic Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The MET/AKT cascade affects neurodevelopment in general populations and face recognition in patients with autism.
|
22558359 |
2012 |
Autistic Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This is the first attempt to replicate associations in Chinese autism samples, and our result provides evidence that MET variants may be relevant to autism susceptibility in the Chinese Han population.
|
22110649 |
2011 |
Autistic Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The autism risk genes MET and PLAUR differentially impact cortical development.
|
21328570 |
2011 |
Autistic Disorder
|
0.400 |
Biomarker
|
disease |
CTD_human |
The autism risk genes MET and PLAUR differentially impact cortical development.
|
21328570 |
2011 |
Autistic Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association of a MET genetic variant with autism-associated maternal autoantibodies to fetal brain proteins and cytokine expression.
|
22833194 |
2011 |
Autistic Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The MET proto-oncogene is primarily linked to tumor metastasis, but MET is also involved in neurodevelopment and influences risk for autism.
|
20080979 |
2010 |
Autistic Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These data indicate that the MET C allele influences at least two of the three domains of the autism triad.
|
19548256 |
2010 |
Autistic Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study is the third independent study to find the rs1858830 C variant in the MET gene promoter to be associated with autism.
|
19681062 |
2009 |
Autistic Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Altered regulation of human MET expression has been implicated in autism.
|
19732764 |
2009 |
Autistic Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
MET is best known as an oncogene, but its signalling also participates in immune function, peripheral organ development and repair, and the development of the cerebral cortex and cerebellum (all of which have been observed earlier as being disregulated in individuals with autism).
|
19002214 |
2009 |
Autistic Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Distinct genetic risk based on association of MET in families with co-occurring autism and gastrointestinal conditions.
|
19255034 |
2009 |
Autistic Disorder
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Disruption of cerebral cortex MET signaling in autism spectrum disorder.
|
17696172 |
2007 |
Autistic Disorder
|
0.400 |
Biomarker
|
disease |
CTD_human |
These data implicate reduced MET gene expression in autism susceptibility, providing evidence of a previously undescribed pathophysiological basis for this behaviorally and medically complex disorder.
|
17053076 |
2006 |
Autistic Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These data implicate reduced MET gene expression in autism susceptibility, providing evidence of a previously undescribed pathophysiological basis for this behaviorally and medically complex disorder.
|
17053076 |
2006 |