Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 Biomarker disease BEFREE Additionally, given that MET is classified as a high confidence autism risk gene, the data suggest that projection neuron subpopulations may be differentially vulnerable to disorder-associated genetic variation. 29190358 2019
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 Biomarker disease BEFREE We discovered that the intracellular signaling cascade requires activation of the receptor tyrosine kinase MET, which is a well known autism risk factor. 30914448 2019
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 GeneticVariation disease BEFREE Control of cortical synapse development and plasticity by MET receptor tyrosine kinase, a genetic risk factor for autism. 31746037 2019
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 Biomarker disease BEFREE The Pleiotropic MET Receptor Network: Circuit Development and the Neural-Medical Interface of Autism. 27837921 2017
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 Biomarker disease BEFREE Proteomics in three independent developing neocortical synaptosomal preparations identified putative interacting proteins of the ligand-activated MET receptor tyrosine kinase, an autism risk gene that mediates synapse development. 27086544 2016
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 Biomarker disease BEFREE Implication of MET in normal and pathological brain development opens new perspectives for understanding the pathophysiology of autism and for eventual therapeutical clues. 24909855 2014
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 AlteredExpression disease BEFREE Unlike many autism risk genes that encode synaptic proteins, the spatial and temporal expression pattern of MET RTK indicates this signaling system is ideally situated to regulate neuronal growth, functional maturation, and establishment of functional brain circuits, particularly in those brain structures involved in higher levels of cognition, social skills, and executive functions. 24290385 2013
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 AlteredExpression disease BEFREE Transcriptional regulation of the MET receptor tyrosine kinase gene by MeCP2 and sex-specific expression in autism and Rett syndrome. 24150225 2013
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 Biomarker disease BEFREE The MET/AKT cascade affects neurodevelopment in general populations and face recognition in patients with autism. 22558359 2012
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 GeneticVariation disease BEFREE This is the first attempt to replicate associations in Chinese autism samples, and our result provides evidence that MET variants may be relevant to autism susceptibility in the Chinese Han population. 22110649 2011
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 GeneticVariation disease BEFREE The autism risk genes MET and PLAUR differentially impact cortical development. 21328570 2011
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 Biomarker disease CTD_human The autism risk genes MET and PLAUR differentially impact cortical development. 21328570 2011
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 GeneticVariation disease BEFREE Association of a MET genetic variant with autism-associated maternal autoantibodies to fetal brain proteins and cytokine expression. 22833194 2011
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 Biomarker disease BEFREE The MET proto-oncogene is primarily linked to tumor metastasis, but MET is also involved in neurodevelopment and influences risk for autism. 20080979 2010
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 GeneticVariation disease BEFREE These data indicate that the MET C allele influences at least two of the three domains of the autism triad. 19548256 2010
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 GeneticVariation disease BEFREE This study is the third independent study to find the rs1858830 C variant in the MET gene promoter to be associated with autism. 19681062 2009
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 AlteredExpression disease BEFREE Altered regulation of human MET expression has been implicated in autism. 19732764 2009
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 Biomarker disease BEFREE MET is best known as an oncogene, but its signalling also participates in immune function, peripheral organ development and repair, and the development of the cerebral cortex and cerebellum (all of which have been observed earlier as being disregulated in individuals with autism). 19002214 2009
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 GeneticVariation disease BEFREE Distinct genetic risk based on association of MET in families with co-occurring autism and gastrointestinal conditions. 19255034 2009
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 AlteredExpression disease LHGDN Disruption of cerebral cortex MET signaling in autism spectrum disorder. 17696172 2007
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 Biomarker disease CTD_human These data implicate reduced MET gene expression in autism susceptibility, providing evidence of a previously undescribed pathophysiological basis for this behaviorally and medically complex disorder. 17053076 2006
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 AlteredExpression disease BEFREE These data implicate reduced MET gene expression in autism susceptibility, providing evidence of a previously undescribed pathophysiological basis for this behaviorally and medically complex disorder. 17053076 2006