KITLG, KIT ligand, 4254

N. diseases: 249; N. variants: 23
Disease: Malignant neoplasm of testis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0153594
Disease: Malignant neoplasm of testis
Malignant neoplasm of testis 		0.430 GeneticVariation disease BEFREE Single-nucleotide polymorphisms in the KITLG gene showed significant associations, but only with testicular cancer. 22140272 2012
CUI: C0153594
Disease: Malignant neoplasm of testis
Malignant neoplasm of testis 		0.430 GeneticVariation disease GWASDB A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility. 21551455 2011
CUI: C0153594
Disease: Malignant neoplasm of testis
Malignant neoplasm of testis 		0.430 GeneticVariation disease BEFREE Although most variants are cancer specific, pleiotropy has been observed for several variants, for example, variants at the 8q24 locus and breast, ovarian and prostate cancers or variants in KITLG in relation to hair color and testicular cancer. 21459759 2011
CUI: C0153594
Disease: Malignant neoplasm of testis
Malignant neoplasm of testis 		0.430 Biomarker disease CTD_human A genome-wide association study of testicular germ cell tumor. 19483681 2009
CUI: C0153594
Disease: Malignant neoplasm of testis
Malignant neoplasm of testis 		0.430 GeneticVariation disease GWASDB Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer. 19483682 2009
CUI: C0153594
Disease: Malignant neoplasm of testis
Malignant neoplasm of testis 		0.430 Biomarker disease CTD_human Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer. 19483682 2009
CUI: C0153594
Disease: Malignant neoplasm of testis
Malignant neoplasm of testis 		0.430 Biomarker disease BEFREE Molecular genetic alterations of known protoncogenes and growth factors, e.g. c-kit and its ligand SCF as well as hst1 and c-myc, are likely to play a role in the development of testicular cancer. 7522081 1994