|
Esophageal Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Our findings suggest that MGMT promoter methylation may be correlated with esophageal cancer carcinogenesis and could be associated with age, lymph node status, and clinical stage.
|
29258097 |
2018 |
|
Esophageal Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, the non-CpG methylation, CHH, and CHG were significantly correlated with O<sup>6</sup>-methylguanine-DNA methyltransferase (p < 0.05) and runt-related transcription factor 3 (p < 0.05) promoters in the development of esophageal cancer.
|
28468586 |
2017 |
|
Esophageal Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In this communication, the methylation status of O-6-methylguanine-DNA methyltransferase gene and the corresponding O-6-methylguanine-DNA methyltransferase protein expression in esophageal cancer from North India has been studied.
|
28621225 |
2017 |
|
Esophageal Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Thus, detection of MGMT promoter methylation may be utilized as a valuable diagnostic marker for EC.
|
25015189 |
2014 |
|
Esophageal Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We found that MGMT G132R, from a human esophageal tumor, and MGMT G156C, from a human colorectal cancer cell line, are unable to rescue methyltransferase-deficient Escherichia coli as well as wild type (WT) human MGMT after treatment with a methylating agent.
|
23065697 |
2014 |
|
Esophageal Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Results suggest that the DNA hypermethylation of MGMT is an important mechanism for MGMT gene silencing resulting in esophageal cancer development and is influenced by the environmental factors.
|
25520135 |
2014 |
|
Esophageal Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Nineteen percent of the screened population (137/740) had confirmed tissue and/or serum MGMT promoter methylation, including 25% (57 of 229) for CRC, 36% (55 of 154) for esophageal cancer, 11% (12 of 113) for head and neck cancer, and 5% (13 of 242) for non-small cell lung carcinoma.
|
23443801 |
2013 |
|
Esophageal Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In conclusion, MGMT variants at codon 84 and codon143 may not be involved in the susceptibility of the Kashmiri population to esophageal cancer.
|
22994708 |
2012 |
|
Esophageal Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In conclusion, loss of MGMT expression leads EC109 esophageal cancer cells to have increased malignant behavior, which may correlate with its high Ezrin protein expression.
|
22196440 |
2012 |
|
Esophageal Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We compared the frequencies of polymorphisms in ten genes that have been hypothesized to have a role in risk of EC (CYP1A1, CYP2A6, CYP2E1, GSTM1, GSTP1, GSTT1, ADH2, ADH3, ALDH2, and O6-MGMT) among three Iranian ethnic groups with highly varying rates of EC.
|
15327835 |
2004 |
|
Esophageal Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
To screen for possible mutations in the MGMT polypeptide in EC patients, we analyzed a highly conserved region of the MGMT gene in 40 EC tissues and lymphocytes of 6 high-risk EC family members from high EC areas of Northern China by polymerase chain reaction single-strand conformation polymorphism and by direct sequencing of PCR products.
|
9180136 |
1997 |