|
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We obtained the final diagnosis of ES/PNET by immunohistochemical molecular study with positive staining for the MIC2 gene product (CD99) and a Ewing sarcoma breakpoint region 1 (EWSR1) gene rearrangement.
|
24158076 |
2013 |
|
Ewings sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CD99 is present in many human cell types, including high-level surface expression on pediatric B and T leukemias and Ewing tumors (ETs).
|
23152061 |
2012 |
|
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD99 and FLI-1 are the currently accepted immunohistochemical markers for Ewing sarcoma, but their accuracy has been controversial.
|
22446943 |
2012 |
|
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated CD99 immunoreactivity using immunohistochemistry and Ewing's sarcoma / Friend leukaemia virus integration 1 (EWS/FLI1) translocation using the fluorescence in situ hybridization (FISH) method in 23 cases.
|
21267687 |
2011 |
|
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Together, these data indicate a new role for CD99 in preventing neural differentiation of EWS cells and suggest that blockade of CD99 or its downstream molecular pathway may be a new therapeutic approach for EWS.
|
20197622 |
2010 |
|
Ewings sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This morphology, along with a polyphenotypic immunoprofile, including the expression of vimentin/CD99/cytokeratins/alpha-smooth muscle actin and vimentin/CD99/S-100 protein in case 1 and case 2, respectively, suggested the possibility of Ewing sarcoma (EWS)/PNET.
|
19243895 |
2009 |
|
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Diagnostic utility of FLI-1 monoclonal antibody and dual-colour, break-apart probe fluorescence in situ (FISH) analysis in Ewing's sarcoma/primitive neuroectodermal tumour (EWS/PNET). A comparative study with CD99 and FLI-1 polyclonal antibodies.
|
17163841 |
2006 |
|
Ewings sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of MIC2 and the genetic rearrangement of EWS-FLI1 are considered to be highly specific to the pPNET/ES.
|
11304041 |
2001 |
|
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Also, it should be remembered that cytoplasmic staining for MIC2 protein may occur in sarcomas other than PNET/ES.
|
10563198 |
1999 |
|
Ewings sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Herein we have analysed five ENB tumour specimens for trisomy 8 by fluorescence in situ hybridization (FISH), for the presence of EWS gene rearrangements by FISH, reverse transcription polymerase chain reaction and Southern blot analyses, as well as for the expression of the Ewing sarcoma-associated MIC2 antigen by immunohistochemistry.
|
10574242 |
1999 |
|
Ewings sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ewing's sarcoma, peripheral primitive neuroectodermal tumors, and Askin tumors are referred to as Ewing tumors (ETs), and are characterized by high MIC2 expression and a t(11;22)(q24;q12) or other rearrangements involving 22q12.
|
10451705 |
1999 |
|
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A limited panel of antibodies can lead to an erroneous diagnosis; B-lymphoblastic lymphoma may be negative for CD45 and CD20 but positive for CD99 and even for keratin, mimicking Ewing's sarcoma.
|
9669342 |
1998 |
|
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Both cases of Ewing's sarcoma and the four primitive neuroectodermal tumour specimens were immunoreactive for MIC 2.
|
9072004 |
1997 |
|
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Based on the cytogenetic analysis, Ewing's sarcoma is related closely with PNET as shown by MIC2-protein reactivity.
|
9103213 |
1997 |
|
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunohistochemically, the tumor cells stained strongly positive for HBA71(p30/32MIC2), a surface glycoprotein specific to PNET and Ewing's sarcoma.
|
8726854 |
1996 |
|
Ewings sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In an attempt to further diagnostically distinguish the two, 33 SSCs were analyzed from both pulmonary and extrapulmonary sites for the MIC2 gene product, a cell surface antigen strongly and reliably expressed in PNETs and Ewing's sarcoma (ES).
|
7524308 |
1994 |
|
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Three 12E7+ lymphoblastic lymphomas were primary in bone and were of B-progenitor lineage; Ewing's sarcoma was included in the initial differential diagnosis of these cases.
|
8163272 |
1994 |
|
Ewings sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
EWS rearrangement in Ewing's sarcoma and peripheral neuroectodermal tumor. Molecular detection and correlation with cytogenetic analysis and MIC2 expression.
|
8287228 |
1993 |
|
Ewings sarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, no influence of the Ewing's tumor-specific translocation t(11;22) on MIC2 expression could be discerned.
|
1733829 |
1992 |
|
Ewings sarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MIC2 is a specific marker for Ewing's sarcoma and peripheral primitive neuroectodermal tumors. Evidence for a common histogenesis of Ewing's sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberration.
|
1848471 |
1991 |
|
Ewings sarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In ES- and pPNET-derived cell lines MIC2 expression is significantly enhanced.
|
1695726 |
1990 |