|
Neuroblastoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
ASCL1 and LMO1 directly regulate the expression of CRC genes, indicating that ASCL1 is a member and LMO1 is a coregulator of the ADRN neuroblastoma CRC.
|
31819055 |
2019 |
|
Neuroblastoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Lastly, shRNA knockdown of HES4 in human neuroblastoma cells altered MASH1 and P21 mRNA expression and markedly increased mutated HTT-induced aggregates and cell death.
|
25480889 |
2015 |
|
Neuroblastoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Exposure of human neuroblastoma-derived Kelly cells to 1% O2 significantly decreased ASCL1 mRNA and hASH1 protein levels.
|
25124043 |
2014 |
|
Neuroblastoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Tat-PTD-modified oncolytic adenovirus driven by the SCG3 promoter and ASH1 enhancer for neuroblastoma therapy.
|
23889332 |
2013 |
|
Neuroblastoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
The up-regulation of Mash1 remarkably accelerated the proliferation of SH-SY5Y neuroblastoma cells, while siRNA-mediated knockdown of LMO3 induced inhibition of growth of SH-SY5Y cells in association with a significant down-regulation of Mash1.
|
21573214 |
2011 |
|
Neuroblastoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Our data suggest that the ASCL1-pathway is responsible for the up-regulation of IGF2 during NB differentiation.
|
20842449 |
2011 |
|
Neuroblastoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
We conclude that (1) an integrated morphologic and biomarker algorithm may better optimize the early diagnosis of poorly differentiated sinonasal and skull-base tumors; (2) molecular analysis may assist in future biological stratification of certain classes of these tumors; and (3) the human achaete-scute homolog-1 gene transcript is a nonspecific marker for the diagnosis of neuroblastoma.
|
19150107 |
2009 |
|
Neuroblastoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
With the aim of developing a targeting vector for neuroblastoma, we cloned and characterized an enhancer in the 5'-flanking regions of the MASH1 gene by a random-trap method from a 36 kb cosmid DNA.
|
17124508 |
2007 |
|
Neuroblastoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
We show here that the Mash1 promoter regulating the PNP gene confers a cell-type selective toxicity in neuroblastoma cell lines.
|
15390277 |
2005 |
|
Neuroblastoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Using a human neuroblastoma cDNA library and the yeast two-hybrid system to identify novel HASH-1-interacting proteins, we isolated ubiquilin-1 (DA41, hPLIC-1), a gene that contains multiple ubiquitin-related domains.
|
15492808 |
2004 |
|
Neuroblastoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that SCLC and NB have complicated mechanisms of IFN-gamma-inducible CIITA transcription deficiency through the overexpressed HASH-1, L-myc, and N-myc.
|
12107114 |
2002 |
|
Neuroblastoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
To identify the roles of the bHLH factor and E-box elements in regulating PACE4 gene expression in neural development, we analysed the effects of human achaete-scute homologue 1 (hASH-1) on PACE4 gene expression with various neuroblastoma cell lines.
|
11736660 |
2001 |
|
Neuroblastoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Our data show that functional sympathetic neuronal differentiation of neuroblastoma cells is associated with transient activation of HES-1 and down-regulation of HASH-1 expression.
|
11054669 |
2000 |
|
Neuroblastoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Furthermore, E2-2 seems to be one of the major HASH-1 interacting proteins in extracts from neuroblastoma cells.
|
10903890 |
2000 |
|
Neuroblastoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
This occurred concomitant with induction of neurite outgrowth and expression of the neuronal marker genes GAP-43 and neuropeptide Y. Constitutive expression of exogenous HASH-1 did not alter the capacity of the neuroblastoma cells to differentiate in response to differentiation-inducing agents.
|
10080936 |
1999 |
|
Neuroblastoma
|
0.200 |
Biomarker
|
disease |
HPO |
|
|
|