Malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
N-myc or Ascl1 activates endogenous INSM1 expression in lung cancer cells.
|
29501727 |
2018 |
Malignant neoplasm of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conclude that SCNN1A/αENaC is a direct transcriptional target of the neuroendocrine lung cancer lineage oncogene ASCL1 that can be pharmacologically targeted with antitumor effects.
|
29413762 |
2018 |
Malignant neoplasm of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
-To evaluate the specificity and sensitivity of mASH1 in various normal and neoplastic tissues, including lung cancers.
|
27628324 |
2017 |
Malignant neoplasm of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Analysis of downstream targets of ASCL1 represents an important advance in the development of targeted therapy for the neuroendocrine class of lung cancers, providing a significant step forward in the understanding and therapeutic targeting of the molecular vulnerabilities of neuroendocrine lung cancer.
|
25267614 |
2014 |
Malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
ASCL1 mRNA expression was found almost exclusively in smokers with AD, in contrast to non-smokers and other lung cancer subtypes.
|
24037524 |
2014 |
Malignant neoplasm of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression of nestin and achaete-scute homolog 1 (ASH1) was studied in 21 lung cancer cell lines.
|
23706418 |
2013 |
Malignant neoplasm of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Achaete-scute homologue-1 (ASH1) stimulates migration of lung cancer cells through Cdk5/p35 pathway.
|
22696682 |
2012 |
Malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We examined human ASH1 (hASH1) expression across a comprehensive panel of human lung cancer cell lines, primary human lung tumors and normal fetal and post-natal lungs.
|
21684625 |
2012 |
Malignant neoplasm of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results elucidate an ASH1 effector axis in NE-lung cancers that is functionally pivotal in controlling NE features and the alleviation from YAP1-mediated growth inhibition.
|
21856745 |
2011 |
Malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We found that this rearrangement disrupted the hypothetical gene C12orf42 and brought the Achaete-scute complex homolog 1 gene into proximity of the TRA enhancer, which encodes a member of the basic helix-loop-helix family of transcription factors and is overexpressed in thyroid and lung cancers.
|
20659153 |
2010 |
Malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our data indicate a specific role for ASCL1 in regulating the expression of the CHRNA5/A3/B4 lung cancer susceptibility locus.
|
20124469 |
2010 |
Malignant neoplasm of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results provide important clues for a better understanding of the molecular and cellular biological roles of ASH1 in the process of carcinogenesis of lung cancers with neuroendocrine features and warrant future investigations to shed light on the lineage-specific dependency of this transcription factor with dual functions.
|
18339843 |
2008 |
Malignant neoplasm of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Knockdown of hASH1 gene in human lung cancer cells in vitro suppressed growth by increasing apoptosis.
|
17507989 |
2007 |
Malignant neoplasm of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since ATOH1 is not known to be involved in normal lung development, our results suggest that aberrant activation of ATOH1 leads to a neuroendocrine phenotype similar to what is observed for ASCL1 activation during normal neuroendocrine development and in lung malignancies.
|
17549667 |
2007 |
Malignant neoplasm of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
As ASCL has been implicated in neuroendocrine, medullary thyroid and small-cell lung cancers, we chose to examine the role of ASCL1 in the astrocytoma development.
|
16103883 |
2005 |
Malignant neoplasm of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study therefore suggests that ASH1 plays a crucial role in lung cancer development and may be an effective therapeutic target in lung cancers with neuroendocrine features.
|
16322211 |
2005 |
Malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we show that GFI1, as with ASH1, is expressed in neuroendocrine lung cancer cell lines and that GFI1 in lung cancer cell lines functions as a DNA-binding transcriptional repressor protein.
|
15466176 |
2004 |
Malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In small cell lung cancer (SCLC), the most lethal form of lung cancer, the gene is highly expressed and the expression of HASH1 correlates with NE features found in SCLCs.
|
11948117 |
2002 |
Malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression.
|
9144241 |
1997 |
Malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We show here that human achaete-scute homologue-1 (hASH1) is selectively expressed in normal fetal pulmonary neuroendocrine cells, as well as in the diverse range of lung cancers with neuroendocrine features.
|
9126746 |
1997 |
Malignant neoplasm of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, cultured lines of non-SCLC lung cancers and a panel of normal adult human tissues showed no detectable hASH1 transcripts.
|
8390674 |
1993 |