|
Hereditary Non-Polyposis Colon Cancer Type 2
|
0.710 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Hereditary Non-Polyposis Colon Cancer Type 2
|
0.710 |
CausalMutation
|
disease |
CLINVAR |
In vitro transcription/translation assay for the screening of hMLH1 and hMSH2 mutations in familial colon cancer.
|
7557107 |
1995 |
|
Hereditary Non-Polyposis Colon Cancer Type 2
|
0.710 |
GeneticVariation
|
disease |
UNIPROT |
Genomic structure of human mismatch repair gene, hMLH1, and its mutation analysis in patients with hereditary non-polyposis colorectal cancer (HNPCC)
|
7757073 |
1995 |
|
Hereditary Non-Polyposis Colon Cancer Type 2
|
0.710 |
Biomarker
|
disease |
CLINGEN |
Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs.
|
7892206 |
1995 |
|
Hereditary Non-Polyposis Colon Cancer Type 2
|
0.710 |
Biomarker
|
disease |
CLINGEN |
Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer.
|
8145827 |
1994 |
|
Hereditary Non-Polyposis Colon Cancer Type 2
|
0.710 |
GeneticVariation
|
disease |
UNIPROT |
CpG dinucleotides in the hMSH2 and hMLH1 genes are hotspots for HNPCC mutations.
|
8566964 |
1996 |
|
Hereditary Non-Polyposis Colon Cancer Type 2
|
0.710 |
GeneticVariation
|
disease |
UNIPROT |
Majority of hMLH1 mutations responsible for hereditary nonpolyposis colorectal cancer cluster at the exonic region 15-16.
|
8571956 |
1996 |
|
Hereditary Non-Polyposis Colon Cancer Type 2
|
0.710 |
Biomarker
|
disease |
CLINGEN |
Germ line mutations of hMSH2 and hMLH1 genes in Japanese families with hereditary nonpolyposis colorectal cancer (HNPCC): usefulness of DNA analysis for screening and diagnosis of HNPCC patients.
|
8581513 |
1995 |
|
Hereditary Non-Polyposis Colon Cancer Type 2
|
0.710 |
CausalMutation
|
disease |
CLINVAR |
Germline mutations of hMLH1 and hMSH2 genes in Korean hereditary nonpolyposis colorectal cancer.
|
8797773 |
1996 |
|
Hereditary Non-Polyposis Colon Cancer Type 2
|
0.710 |
GeneticVariation
|
disease |
UNIPROT |
Germline mutations of hMLH1 and hMSH2 genes in Korean hereditary nonpolyposis colorectal cancer.
|
8797773 |
1996 |
|
Hereditary Non-Polyposis Colon Cancer Type 2
|
0.710 |
CausalMutation
|
disease |
CLINVAR |
Microsatellite instability and mutation analysis of hMSH2 and hMLH1 in patients with sporadic, familial and hereditary colorectal cancer.
|
8872463 |
1996 |
|
Hereditary Non-Polyposis Colon Cancer Type 2
|
0.710 |
GeneticVariation
|
disease |
UNIPROT |
Microsatellite instability and mutation analysis of hMSH2 and hMLH1 in patients with sporadic, familial and hereditary colorectal cancer.
|
8872463 |
1996 |
|
Hereditary Non-Polyposis Colon Cancer Type 2
|
0.710 |
CausalMutation
|
disease |
CLINVAR |
Mutation screening of MSH2 and MLH1 mRNA in hereditary non-polyposis colon cancer syndrome.
|
8880570 |
1996 |
|
Hereditary Non-Polyposis Colon Cancer Type 2
|
0.710 |
GeneticVariation
|
disease |
UNIPROT |
Characterization of MSH2 and MLH1 mutations in Italian families with hereditary nonpolyposis colorectal cancer.
|
8993976 |
1997 |
|
Hereditary Non-Polyposis Colon Cancer Type 2
|
0.710 |
GeneticVariation
|
disease |
UNIPROT |
Use of SSCP analysis to identify germline mutations in HNPCC families fulfilling the Amsterdam criteria.
|
9048925 |
1997 |
|
Hereditary Non-Polyposis Colon Cancer Type 2
|
0.710 |
GeneticVariation
|
disease |
UNIPROT |
Mutational analysis of the hMLH1 gene using an automated two-dimensional DNA typing system.
|
9067757 |
1997 |
|
Hereditary Non-Polyposis Colon Cancer Type 2
|
0.710 |
GeneticVariation
|
disease |
UNIPROT |
Mean age of tumor onset in hereditary nonpolyposis colorectal cancer (HNPCC) families correlates with the presence of mutations in DNA mismatch repair genes.
|
9218993 |
1997 |
|
Hereditary Non-Polyposis Colon Cancer Type 2
|
0.710 |
GeneticVariation
|
disease |
UNIPROT |
Hereditary nonpolyposis colorectal cancer: causative role of a germline missense mutation in the hMLH1 gene confirmed by the independent occurrence of the same somatic mutation in tumour tissue.
|
9272156 |
1997 |
|
Hereditary Non-Polyposis Colon Cancer Type 2
|
0.710 |
GeneticVariation
|
disease |
UNIPROT |
Hereditary nonpolyposis colorectal cancer (HNPCC): eight novel germline mutations in hMSH2 or hMLH1 genes.
|
9298827 |
1997 |
|
Hereditary Non-Polyposis Colon Cancer Type 2
|
0.710 |
GeneticVariation
|
disease |
UNIPROT |
Hereditary nonpolyposis colorectal cancer families not complying with the Amsterdam criteria show extremely low frequency of mismatch-repair-gene mutations.
|
9311737 |
1997 |
|
Hereditary Non-Polyposis Colon Cancer Type 2
|
0.710 |
GeneticVariation
|
disease |
UNIPROT |
A human compound heterozygote for two MLH1 missense mutations.
|
9326924 |
1997 |
|
Hereditary Non-Polyposis Colon Cancer Type 2
|
0.710 |
GeneticVariation
|
disease |
UNIPROT |
Germline hMSH2 and hMLH1 gene mutations in incomplete HNPCC families.
|
9399661 |
1997 |
|
Hereditary Non-Polyposis Colon Cancer Type 2
|
0.710 |
Biomarker
|
disease |
CLINGEN |
Characterization of MLH1 and MSH2 alternative splicing and its relevance to molecular testing of colorectal cancer susceptibility.
|
9490293 |
1998 |
|
Hereditary Non-Polyposis Colon Cancer Type 2
|
0.710 |
Biomarker
|
disease |
CLINGEN |
Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair.
|
9500552 |
1998 |
|
Hereditary Non-Polyposis Colon Cancer Type 2
|
0.710 |
GeneticVariation
|
disease |
UNIPROT |
Germline mutations of hMLH1 and hMSH2 genes in patients with suspected hereditary nonpolyposis colorectal cancer and sporadic early-onset colorectal cancer.
|
9559627 |
1998 |