|
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
hMLH1 and hMSH2 mRNA expression was previously evaluated by qPCR for 29 NSCLC patients (13 with squamous cell carcinoma [SQC] and 16 with adenocarcinoma [ADC]) and MMR mRNA levels were converted into clinically distinct phenotypic entities.
|
22865300 |
2013 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A novel case of endometrial dedifferentiated adenocarcinoma associated with MLH1 promotor hypermethylation and microsatellite instability.
|
30173944 |
2018 |
|
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
A total of 582 colon adenocarcinomas were evaluated using methylation-specific PCR for 5 markers (hMLH1, P16, MINT1, MINT2, and MINT31).
|
18922929 |
2008 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
CIMP(+) was detected in 27 of 99 (27.3%) duodenal adenocarcinomas and was associated with MSI (P = 0.011) and MLH1 methylation (P < 0.001), but not with KRAS mutations (P = 0.114), as compared with CIMP(-) tumors.No BRAF V600E mutation was detected.
|
22825585 |
2012 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Hereditary and somatic DNA mismatch repair gene mutations in sporadic endometrial carcinoma.
|
11474654 |
2001 |
|
Adenocarcinoma
|
0.100 |
PosttranslationalModification
|
group |
LHGDN |
Hypermethylation of hMLH1, HPP1, p14(ARF), p16(INK4A) and APC in primary adenocarcinomas of the small bowel.
|
16619216 |
2006 |
|
Adenocarcinoma
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Hypermethylation of hMLH1, HPP1, p14(ARF), p16(INK4A) and APC in primary adenocarcinomas of the small bowel.
|
16619216 |
2006 |
|
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Hypermethylation of Chfr and hMLH1 was observed in: 10% (1/10) and 0% (0/10) of low-grade NIN (L-NIN); 63% (5/8) and 63% (5/8) of high-grade NIN, including suspicion for carcinoma without invasion (H-NIN); 36% (5/14) and 57% (8/14) of high-grade NIN, including carcinoma without invasion; and 35% (7/20) and 25% (5/20) of submucosal invasive adenocarcinomas, respectively.
|
15735977 |
2005 |
|
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In this study, we evaluated by immunohistochemistry MLH1 and MSH2 protein expression in 132 MSI-H, 23 MSI-L (low-frequency MSI), and 150 microsatellite stable (MSS) colorectal adenocarcinomas.
|
12118112 |
2002 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
KRAS codon 12/13 and 59/61 and BRAF V600E mutations, MSI, and MGMT and hMLH1 methylation and expression in 42 serrated adenocarcinomas and 17 serrated adenomas were compared with those in 59 non-serrated colorectal carcinomas (CRCs) and nine adenomas.
|
21457162 |
2011 |
|
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Loss of MLH-1 (25%) or MGMT (50%) expression and BRAF or KRAS mutations (50%) were inconsistently present in adenocarcinomas and were not identified in combination in any cases.
|
18059232 |
2007 |
|
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
LHGDN |
Loss of hMLH1 expression is associated with less aggressive clinicopathological features in sporadic endometrioid endometrial adenocarcinoma.
|
16984511 |
2006 |
|
Adenocarcinoma
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Methylation of hMLH1 is likely to explain the increased frequency of high-level MSI (16%) and methylation of MGMT is postulated to explain the low-level MSI (29%) in serrated adenocarcinomas.
|
17204027 |
2007 |
|
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Microsatellite instability and hMLH1/hMSH2 expression in Barrett esophagus-associated adenocarcinoma.
|
11301392 |
2001 |
|
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Mismatch repair defects were seen in adenocarcinomas and "rare" tumors with MLH1 silencing.
|
29438113 |
2019 |
|
Adenocarcinoma
|
0.100 |
PosttranslationalModification
|
group |
LHGDN |
Our results indicate that Por tumorigenesis strongly correlates with MSI and methylation of the p16 and hMLH1 promoter region.
|
18161865 |
2008 |
|
Adenocarcinoma
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Our results indicate that Por tumorigenesis strongly correlates with MSI and methylation of the p16 and hMLH1 promoter region.
|
18161865 |
2008 |
|
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results suggest that loss of MLH1 expression in non-dysplastic crypts in SSAs precedes the development of MLH1-deficient dysplasia and adenocarcinoma, and may be a biomarker of an advanced serrated polyp even in the absence of dysplasia.
|
30974487 |
2019 |
|
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Overexpression of hMLH1 and the adenocarcinoma subtype were both independent factors that related to EGFR mutations in NSCLCs (p=0.013 and p<0.0005).
|
24205245 |
2013 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Remarkably, in a patient with LS and germline mutation of MLH1 gene, pyloric gland adenoma (PGA) transformed to adenocarcinoma during follow-up.
|
24518125 |
2014 |
|
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
SFRP2 and IGF2 DMR0 showed significant methylation changes at the adenomatous polyp stage, followed by the CIMP markers CDKN2A and hMLH1 at the adenocarcinoma stage.
|
21068132 |
2011 |
|
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The incidence of poorly differentiated adenocarcinoma was 70.6% in HNPCC group among high frequency microsatellite instability (MSI-H), which was higher than the other two groups, which had 50% and 50% respectively.
|
16937450 |
2006 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
There was no significant association between the hMLH1 -93G-->A genotype and the risk for adenocarcinoma or small cell carcinoma.
|
15382050 |
2004 |
|
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
These polyps contain BRAF mutations and are prone to epigenetic methylation that ultimately silences MLH1, leading to MSI and heralding progression of dysplasia to invasive adenocarcinoma.
|
25602793 |
2015 |
|
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
LHGDN |
These results indicate that an age-related increase of medullary-type tumors in poorly differentiated adenocarcinoma may play an important role in the increase of absent hMLH1 expression and MSI in colorectal carcinoma.
|
16984616 |
2006 |