Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
This study aimed to identify low-level constitutional MLH1 epimutations and determine its causal role in patients with MLH1-hypermethylated colorectal cancer.Eighteen patients with MLH1-hypermethylated colorectal tumors in whom MLH1 methylation was previously undetected in blood by methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) were screened for MLH1 methylation using highly sensitive MS-melting curve analysis (MS-MCA).
|
31779681 |
2019 |
Colorectal Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
HES1 loss correlates with the development of human right-sided colorectal tumors with epigenetic loss of MLH1.
|
27639802 |
2017 |
Colorectal Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We investigated the clinical and molecular features of the MSH6 variants, such as the family cancer history, pathological findings, immunohistochemistry, methylation status of the MLH1 promoter and BRAF mutation in the colorectal tumor.
|
24100870 |
2013 |
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Analysis of colorectal tumors from probands included a microsatellite instability study and immunohistochemical evaluation for MLH1 and MSH2.
|
20305446 |
2010 |
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
These preliminary data suggest that lower MLH1 expression in the normal colonic mucosa, at least in the ascending colon, may be associated with increased risk of incident, sporadic colorectal adenoma, as well as with modifiable risk factors for colorectal neoplasms, thus supporting further investigation of MLH1 expression as a potential "treatable" biomarker of risk for colorectal neoplasms.
|
19423536 |
2009 |
Colorectal Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
LHGDN |
Deficient mismatch repair system in patients with sporadic advanced colorectal cancer.
|
19165197 |
2009 |
Colorectal Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Microsatellite instability, MLH1 promoter methylation, and BRAF mutation analysis in sporadic colorectal cancers of different ethnic groups in Israel.
|
19127559 |
2009 |
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study.
|
18718023 |
2008 |
Colorectal Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
MLH1 -93G>A promoter polymorphism and risk of mismatch repair deficient colorectal cancer.
|
18712731 |
2008 |
Colorectal Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
LHGDN |
Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening.
|
18990764 |
2008 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Sporadic colon cancer: mismatch repair immunohistochemistry and microsatellite instability in Omani subjects.
|
18299982 |
2008 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study.
|
18718023 |
2008 |
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Oncoprotein Bcl-2 and microsatellite instability are associated with disease-free survival and treatment response in colorectal cancer.
|
18949393 |
2008 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Fhit, Mlh1, P53 and phenotypic expression in the early stage of colorectal neoplasms.
|
18097574 |
2008 |
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Oncoprotein Bcl-2 and microsatellite instability are associated with disease-free survival and treatment response in colorectal cancer.
|
18949393 |
2008 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Fhit, Mlh1, P53 and phenotypic expression in the early stage of colorectal neoplasms.
|
18097574 |
2008 |
Colorectal Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
LHGDN |
Redundant DNA methylation in colorectal cancers of Lynch-syndrome patients.
|
18618713 |
2008 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Expression of the hMLH1 gene is a possible predictor for the clinical response to 5-fluorouracil after a surgical resection in colorectal cancer.
|
18497967 |
2008 |
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Expression of the hMLH1 gene is a possible predictor for the clinical response to 5-fluorouracil after a surgical resection in colorectal cancer.
|
18497967 |
2008 |
Colorectal Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Reduced mRNA expression in paraffin-embedded tissue identifies MLH1- and MSH2-deficient colorectal tumours and potential mutation carriers.
|
18581137 |
2008 |
Colorectal Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
LHGDN |
Further evidence for heritability of an epimutation in one of 12 cases with MLH1 promoter methylation in blood cells clinically displaying HNPCC.
|
18301449 |
2008 |
Colorectal Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
LHGDN |
Associations of dietary methyl donor intake with MLH1 promoter hypermethylation and related molecular phenotypes in sporadic colorectal cancer.
|
18339680 |
2008 |
Colorectal Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Phenotype comparison of MLH1 and MSH2 mutation carriers in a cohort of 1,914 individuals undergoing clinical genetic testing in the United States.
|
18708397 |
2008 |
Colorectal Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
LHGDN |
Coexisting somatic promoter hypermethylation and pathogenic MLH1 germline mutation in Lynch syndrome.
|
17973250 |
2008 |
Colorectal Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The patient with the epimutation had developed an epidermoid lip carcinoma and an early-onset colorectal tumor with MSI, no MLH1 expression, and loss of heterozygosity of the gene.
|
17309645 |
2007 |