|
Carcinogenesis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Thus, MLK-3 signaling affects numerous cellular processes, raising the possibility that MLK-3 might play a role in oncogenesis.
|
9187672 |
1997 |
|
Hereditary Malignant Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Since the MEN1 susceptibility locus is also located within the 11q13.1 region, we have carried out Southern and Northern blot analyses, as well as protein truncation assays to establish whether abnormalities in MLK-3 lead to the development of this familial cancer syndrome.
|
9187672 |
1997 |
|
Rheumatoid Arthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
RT-PCR studies of MAP3K gene expression in RA and osteoarthritis synovial tissue demonstrated mitogen-activated protein kinase/ERK kinase kinase (MEKK) 1, MEKK2, apoptosis-signal regulating kinase-1, TGF-beta activated kinase 1 (TAK1) gene expression while only trace amounts of MEKK3, MEKK4, and MLK3 mRNA were detected.
|
14734742 |
2004 |
|
Degenerative polyarthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
RT-PCR studies of MAP3K gene expression in RA and osteoarthritis synovial tissue demonstrated mitogen-activated protein kinase/ERK kinase kinase (MEKK) 1, MEKK2, apoptosis-signal regulating kinase-1, TGF-beta activated kinase 1 (TAK1) gene expression while only trace amounts of MEKK3, MEKK4, and MLK3 mRNA were detected.
|
14734742 |
2004 |
|
Malignant neoplasm of prostate
|
0.020 |
Biomarker
|
disease |
BEFREE |
Mixed lineage kinase 3 connects reactive oxygen species to c-Jun NH2-terminal kinase-induced mitochondrial apoptosis in genipin-treated PC3 human prostate cancer cells.
|
17707342 |
2007 |
|
Prostate carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Mixed lineage kinase 3 connects reactive oxygen species to c-Jun NH2-terminal kinase-induced mitochondrial apoptosis in genipin-treated PC3 human prostate cancer cells.
|
17707342 |
2007 |
|
HIV Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
RNA interference studies confirm the involvement of endogenous MLK3 in HIV infection, further implicating this kinase as a potential therapeutic target.
|
17257639 |
2007 |
|
Neurodegenerative Disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Aberrant activation of MLK3 has been implicated in neurodegenerative diseases.
|
17711861 |
2007 |
|
Tumor Cell Invasion
|
0.080 |
AlteredExpression
|
phenotype |
BEFREE |
Expression of active MLK3 is sufficient to induce the invasion of mammary epithelial cells, which requires AP-1 activity and is accompanied by the expression of several proteins corresponding to AP-1-regulated invasion genes.
|
20514022 |
2010 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
miR-199a regulates the tumor suppressor mitogen-activated protein kinase kinase kinase 11 in gastric cancer.
|
21048306 |
2010 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Here we investigated the effect of MLK3 and its signaling to MAPKs in the acquisition of malignancy in breast cancer.
|
20514022 |
2010 |
|
Malignant Neoplasms
|
0.040 |
GeneticVariation
|
group |
BEFREE |
In conclusion, we have demonstrated for the first time the presence of MLK3 mutations in cancer and its association to mismatch repair deficiency.
|
19955118 |
2010 |
|
Primary malignant neoplasm
|
0.040 |
GeneticVariation
|
group |
BEFREE |
In conclusion, we have demonstrated for the first time the presence of MLK3 mutations in cancer and its association to mismatch repair deficiency.
|
19955118 |
2010 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Here we investigated the effect of MLK3 and its signaling to MAPKs in the acquisition of malignancy in breast cancer.
|
20514022 |
2010 |
|
Oestrogen receptor positive breast cancer
|
0.030 |
Biomarker
|
disease |
BEFREE |
Estrogen suppresses MLK3-mediated apoptosis sensitivity in ER+ breast cancer cells.
|
20145118 |
2010 |
|
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
To assess MLK3's contribution to the breast cancer malignant phenotype in a more physiological setting, we implemented a strategy to inducibly express active MLK3 in the preformed acini of MCF10A cells grown in 3D Matrigel.
|
20514022 |
2010 |
|
Carcinoma
|
0.020 |
Biomarker
|
group |
BEFREE |
This review is focused on the molecular profile of alterations in members of the KRAS signaling pathway (EGFR, KRAS, BRAF, PIK3CA, RASSF1A, and MLK3 genes) in MSI gastrointestinal carcinomas.
|
21070916 |
2010 |
|
Carcinoma
|
0.020 |
GeneticVariation
|
group |
BEFREE |
MLK3 mutations were significantly associated with MSI phenotype in primary tumours (P = 0.0005), occurring in 21% of the MSI carcinomas.
|
19955118 |
2010 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
To assess MLK3's contribution to the breast cancer malignant phenotype in a more physiological setting, we implemented a strategy to inducibly express active MLK3 in the preformed acini of MCF10A cells grown in 3D Matrigel.
|
20514022 |
2010 |
|
Malignant neoplasm of gastrointestinal tract
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In this study, 174 primary gastrointestinal cancers (48 hereditary and 126 sporadic forms) and 7 colorectal cancer cell lines were screened for MLK3 mutations.
|
19955118 |
2010 |
|
Mammary Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
We noted that the activity of the proapoptotic mixed lineage kinase 3 (MLK3) kinase was relatively higher in estrogen receptor-negative (ER(-)) breast tumors, suggesting that E(2) might inhibit MLK3 activity.
|
20145118 |
2010 |
|
estrogen receptor-negative breast cancer
|
0.020 |
Biomarker
|
disease |
BEFREE |
Estrogen suppresses MLK3-mediated apoptosis sensitivity in ER+ breast cancer cells.
|
20145118 |
2010 |
|
Turcot syndrome (disorder)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we have demonstrated for the first time the presence of MLK3 mutations in cancer and its association to mismatch repair deficiency.
|
19955118 |
2010 |
|
Invasive carcinoma of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, MLK3 may be an important therapeutic target for the treatment of invasive breast cancer.
|
20514022 |
2010 |
|
Malignant neoplasm of prostate
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Our studies indicated that MLK3 can induce β-catenin expression via post-translational stabilization in various cancer cells, including prostate cancer.
|
21880738 |
2011 |