KMT2A, lysine methyltransferase 2A, 4297

N. diseases: 535; N. variants: 65
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023448
Disease: Lymphoid leukemia
Lymphoid leukemia
0.400 Biomarker disease BEFREE The MLL gene is a recurrent target for translocations in both acute myeloid and acute lymphoid leukemias. 20175452 2009
CUI: C0023448
Disease: Lymphoid leukemia
Lymphoid leukemia
0.400 Biomarker disease BEFREE We performed fluorescence in situ hybridization (FISH) for an MLL split signal on 223 adult T-ALL samples obtained within the framework of the German Multicenter ALL 07/2003 therapy trial. 22927255 2012
CUI: C0023448
Disease: Lymphoid leukemia
Lymphoid leukemia
0.400 AlteredExpression disease BEFREE Here we show that depending on extrinsic cues, human neonatal CD34(+) cells are readily immortalized along either the myeloid or lymphoid lineage upon MLL-AF9 expression and give rise to mainly lymphoid leukemia in immunocompromised mice. 23178754 2013
CUI: C0023448
Disease: Lymphoid leukemia
Lymphoid leukemia
0.400 Biomarker disease BEFREE The MLL gene is involved in many chromosomal translocations leading to both acute myeloid and lymphoid leukemia. 12665971 2003
CUI: C0023448
Disease: Lymphoid leukemia
Lymphoid leukemia
0.400 GeneticVariation disease BEFREE Therapy-related B-lymphoblastic leukemia associated with Philadelphia chromosome and MLL rearrangement: Single institution experience and the review of the literature. 26259760 2015
CUI: C0023448
Disease: Lymphoid leukemia
Lymphoid leukemia
0.400 GeneticVariation disease BEFREE In this case study, we diagnosed t-MN with KMT2A rearrangement in a patient with history of B-ALL with 9p deletion and gain of X chromosome. 29155023 2017
CUI: C0023448
Disease: Lymphoid leukemia
Lymphoid leukemia
0.400 GeneticVariation disease BEFREE Translocations and amplifications of the mixed lineage leukemia-1 (MLL1) gene are associated with aggressive myeloid and lymphocytic leukemias in humans. 22665483 2012
CUI: C0023448
Disease: Lymphoid leukemia
Lymphoid leukemia
0.400 Biomarker disease BEFREE Chromosomal translocations of the Mixed-lineage leukemia 1 (<i>MLL1</i>) gene generate MLL chimeras that drive the pathogenesis of acute myeloid and lymphoid leukemia. 30573454 2019
CUI: C0023448
Disease: Lymphoid leukemia
Lymphoid leukemia
0.400 GeneticVariation disease BEFREE Except for one case with biallelic KMT2A (MLL) breaks, all cases analyzed by FISH lacked the most common translocations defining molecular subsets of lymphoblastic leukemia/lymphomas. 30578714 2019
CUI: C0023448
Disease: Lymphoid leukemia
Lymphoid leukemia
0.400 GeneticVariation disease BEFREE T-cell lymphoblastic leukemia in early childhood presents NOTCH1 mutations and MLL rearrangements. 19631984 2010
CUI: C0023448
Disease: Lymphoid leukemia
Lymphoid leukemia
0.400 Biomarker disease BEFREE MLL1 is well known to be rearranged in myeloid and lymphoid leukemias in children and adults. 20236313 2010
CUI: C0023448
Disease: Lymphoid leukemia
Lymphoid leukemia
0.400 GeneticVariation disease BEFREE Therapy-related B lymphoblastic leukemia with t(4;11)(q21;q23)/AF4-MLL in a patient with mantle cell lymphoma after recent aggressive chemotherapy: a unique case report. 24817983 2014
CUI: C0023448
Disease: Lymphoid leukemia
Lymphoid leukemia
0.400 Biomarker disease CTD_human Modeling the initiation and progression of human acute leukemia in mice. 17463288 2007
CUI: C0023448
Disease: Lymphoid leukemia
Lymphoid leukemia
0.400 GeneticVariation disease LHGDN Early G2/M checkpoint failure as a molecular mechanism underlying etoposide-induced chromosomal aberrations. 16357944 2006