Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 AlteredExpression disease LHGDN The incidence of T-cell receptor gene rearrangements in childhood B-lineage acute lymphoblastic leukemia is related to immunophenotype and fusion oncogene expression. 16386788 2006
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 AlteredExpression disease LHGDN Involvement of the MLL gene located at chromosome region 11q23 is a frequent occurrence in both acute myelocytic leukemia and acute lymphoblastic leukemia. 14580777 2003
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 AlteredExpression disease BEFREE Prognostic significance of FLT3 mutational status and expression levels in MLL-AF4+ and MLL-germline acute lymphoblastic leukemia. 22705992 2012
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 AlteredExpression disease LHGDN Fusion of an AF4-related gene, LAF4, to MLL in childhood acute lymphoblastic leukemia with t(2;11)(q11;q23). 12743608 2003
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 AlteredExpression disease BEFREE Pro-B-cell to pre-B-cell development in B-lineage acute lymphoblastic leukemia expressing the MLL/AF4 fusion protein. 11719380 2001
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 AlteredExpression disease LHGDN B-cell development in the presence of the MLL/AF4 oncoprotein proceeds in the absence of HOX A7 and HOX A9 expression. 14562113 2003
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 PosttranslationalModification disease BEFREE Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia. 31395602 2019
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 PosttranslationalModification disease BEFREE The partial tandem duplication of ALL1 (MLL) is consistently generated by Alu-mediated homologous recombination in acute myeloid leukemia. 9482895 1998
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease CTD_human Acute lymphoblastic leukemia in infants (< 1 year-of-age) is characterized by a high incidence of MLL rearrangements. 24736461 2014
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease BEFREE We report two cases of AML (M5a and M0) and one case of acute lymphoblastic leukemia containing MLL-AF10 fusion. 11187895 2000
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease BEFREE MLL-AF4 acute lymphocytic leukemia exhibits both myeloid and B-cell surface markers, suggesting that the transformed cells are B-cell myeloid progenitor cells. 23893300 2013
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease BEFREE Two consecutive immunophenotypic switches in a child with MLL-rearranged acute lymphoblastic leukemia. 16709517 2006
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease BEFREE Moreover, aberrant down-regulation of let-7b (~70-fold) in MLL-rearranged acute lymphoblastic leukemia was linked to up-regulation of oncoprotein c-Myc (P(FDR)<0.0001). 21242186 2011
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease BEFREE 11q23 translocations (t(11q23)) are recurring cytogenetic abnormalities in both acute myeloid leukemia (AML) and acute lymphoblastic leukemia, involving the same gene, ALL1 (or MLL). 9529125 1998
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease CTD_human The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias. 25730765 2015
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease LHGDN [Detection of fusion genes resulting from chromosome abnormalities in childhood acute lymphoblastic leukemia]. 16215946 2005
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease BEFREE Depletion of JMJD1C impairs expansion and colony formation of human leukemic cell lines, with the strongest effect observed in the MLL-rearranged ALL cell line SEM. 24501218 2014
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease BEFREE MLL-AF4 acute lymphocytic leukemia has a poor prognosis, and the mechanisms by which these leukemias develop are not understood despite intensive research based on well-known concepts and methods. 20237425 2010
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease BEFREE Expression of BCR-ABL, E2A-PBX1, and MLL-AF4 fusion transcripts in newly diagnosed children with acute lymphoblastic leukemia: a Children's Cancer Group initiative. 9250788 1997
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease BEFREE Although patients with MLL-rearranged acute lymphoblastic leukemia are highly resistant to prednisolone and L-asparaginase, this resistance was not attributed to miR-196b expression. 20494936 2010
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease BEFREE Among the many known MLL fusion partners, AF4 is relatively common, particularly in acute lymphoblastic leukemia in infants. 15269783 2004
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease BEFREE The MLL gene on chromosome 11 band q23 is frequently involved in chromosome translocations in acute lymphoblastic leukemia and acute myeloid leukemia. 10602437 1999
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease BEFREE CDKN1A-mediated responsiveness of MLL-AF4-positive acute lymphoblastic leukemia to Aurora kinase-A inhibitors. 24382688 2014
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease BEFREE The MLL-AF4 fusion gene is a hallmark genomic aberration in high-risk acute lymphoblastic leukemia in infants. 22212479 2012
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.400 Biomarker disease BEFREE The distribution of MLL breakpoints for clinical subtypes (acute lymphoblastic leukemia, acute myeloid leukemia, pediatric and adult) and fused translocation partner genes (TPGs) will be presented, including novel MLL fusion genes. 19262598 2009