|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We used karyotyping, fluorescence in situ hybridization (FISH), Southern blotting, and RT-PCR in order to analyze prospectively 77 infants (less than 1 year of age) with acute lymphoblastic leukemia for the occurrence of 11q23/MLL rearrangements and/or other cytogenetic abnormalities.
|
12200682 |
2002 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A case of infantile acute lymphoblastic leukemia presenting with rearrangement of MLL at 11q23 and apparent insertion or translocation at 10p12.
|
15381373 |
2004 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We report two cases of AML (M5a and M0) and one case of acute lymphoblastic leukemia containing MLL-AF10 fusion.
|
11187895 |
2000 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We used a new approach called panhandle polymerase chain reaction (PCR) to clone an MLL genomic translocation breakpoint in a case of acute lymphoblastic leukemia of infancy in which karyotype analysis was technically unsuccessful and did not show the translocation partner.
|
9389682 |
1997 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Clinical features and outcome of MLL gene rearranged acute lymphoblastic leukemia in infants with additional chromosomal abnormalities other than 11q23 translocation.
|
18448165 |
2008 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Frequency and prognostic significance of t(v;11q23)/KMT2A rearrangements in adult patients with acute lymphoblastic leukemia treated with risk-adapted protocols.
|
27122129 |
2017 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
MLL-AF4 acute lymphocytic leukemia exhibits both myeloid and B-cell surface markers, suggesting that the transformed cells are B-cell myeloid progenitor cells.
|
23893300 |
2013 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
AF4 is the 4q21 gene involved in the acute lymphoblastic leukemia associated t(4;11)(q21;q23) where it forms a fusion gene with MLL.
|
9365243 |
1997 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Acute lymphoblastic leukemia in infants (< 1 year-of-age) is characterized by a high incidence of MLL rearrangements.
|
24736461 |
2014 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Two consecutive immunophenotypic switches in a child with MLL-rearranged acute lymphoblastic leukemia.
|
16709517 |
2006 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Near-precise interchromosomal recombination and functional DNA topoisomerase II cleavage sites at MLL and AF-4 genomic breakpoints in treatment-related acute lymphoblastic leukemia with t(4;11) translocation.
|
11493704 |
2001 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The clinical characteristics, therapy and outcome of 85 adults with acute lymphoblastic leukemia and t(4;11)(q21;q23)/MLL-AFF1 prospectively treated in the UKALLXII/ECOG2993 trial.
|
23349309 |
2013 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, aberrant down-regulation of let-7b (~70-fold) in MLL-rearranged acute lymphoblastic leukemia was linked to up-regulation of oncoprotein c-Myc (P(FDR)<0.0001).
|
21242186 |
2011 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The precise incidence of MLL gene rearrangement in S-ALL still remains to be clarified.
|
9168451 |
1997 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
11q23 translocations (t(11q23)) are recurring cytogenetic abnormalities in both acute myeloid leukemia (AML) and acute lymphoblastic leukemia, involving the same gene, ALL1 (or MLL).
|
9529125 |
1998 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The human AF9/MLLT3 gene is a common fusion partner for the MLL gene in translocations t(9;11)(p22;q23) associated with acute myeloid leukemia and acute lymphocytic leukemia.
|
16001262 |
2005 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A partial nontandem duplication (PNTD) of mixed lineage leukemia (MLL) gene is described in B-cell acute lymphoid leukemia without structural cytogenetic abnormalities at 11q23 and 9p22.
|
11196198 |
2001 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Fms-like tyrosine kinase 3 (FLT3) is highly expressed in acute lymphoblastic leukemia with the mixed-lineage leukemia (MLL) gene rearrangement refractory to chemotherapy.
|
17942916 |
2007 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Analysis of the role of hematopoietic stem-cell transplantation in infants with acute lymphoblastic leukemia in first remission and MLL gene rearrangements: a report from the Children's Oncology Group.
|
21135279 |
2011 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Depletion of JMJD1C impairs expansion and colony formation of human leukemic cell lines, with the strongest effect observed in the MLL-rearranged ALL cell line SEM.
|
24501218 |
2014 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
MLL rearrangements are translocation mutations that cause both acute lymphoblastic leukemia and acute myeloid leukemia (AML).
|
31405949 |
2019 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
MLL-AF4 acute lymphocytic leukemia has a poor prognosis, and the mechanisms by which these leukemias develop are not understood despite intensive research based on well-known concepts and methods.
|
20237425 |
2010 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Expression of BCR-ABL, E2A-PBX1, and MLL-AF4 fusion transcripts in newly diagnosed children with acute lymphoblastic leukemia: a Children's Cancer Group initiative.
|
9250788 |
1997 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although patients with MLL-rearranged acute lymphoblastic leukemia are highly resistant to prednisolone and L-asparaginase, this resistance was not attributed to miR-196b expression.
|
20494936 |
2010 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Among the many known MLL fusion partners, AF4 is relatively common, particularly in acute lymphoblastic leukemia in infants.
|
15269783 |
2004 |