Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The MLL/EB1 cells grew more slowly owing to increased apoptosis in vitro and induced acute monocytic leukemia with an incomplete penetrance and longer survival in vivo.
|
30974389 |
2019 |
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, a precise characterization of KMT2A-r and the fusion partner genes, especially in CKs, is of interest for managing AML.
|
30974445 |
2019 |
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, development of additional methods to detect specific translocation partners of KMT2A and leukemia-specific targeting drugs is important to improve further the outcomes of KMT2A-rearranged AML.
|
30869817 |
2019 |
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Hif-1α Deletion May Lead to Adverse Treatment Effect in a Mouse Model of MLL-AF9-Driven AML.
|
30595549 |
2019 |
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The 3-year DFS of KMT2A-rearranged AML was not significantly poorer than that of other AML (P = 0.09), and no significant difference was also seen in 3-year OS rate (P = 0.21).
|
31707119 |
2019 |
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Translocation (9;11)(p21.3;q23.3) is one of the most common lysine methyltransferase 2A (KMT2A)-rearrangements in <i>de novo</i> and therapy-related acute myeloid leukemia (AML).
|
31807181 |
2019 |
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
C-terminal BRE might be an important contributor to this program because in a case with relapsed AML, we observed an ins(11;2) fusing CHORDC1 to BRE at the region where intragenic transcription starts in KMT2A-rearranged and KAT6A-CREBBP AML.
|
28871137 |
2018 |
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Among them, the translocation t(9;11)(p22;q23), KMT2A-MLLT3, is the most common abnormality accounting for approximately 22% of KMT2A rearrangements in infant AML cases.
|
28595195 |
2017 |
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
A 2-year-old female with AML with MLL rearrangement presented with CNS infiltration.
|
28658145 |
2017 |
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
While β-catenin has been demonstrated as an essential molecule and therapeutic target for various cancer stem cells (CSCs) including those driven by MLL fusions, here we show that transcriptional memory from cells of origin predicts AML patient survival and allows β-catenin-independent transformation in MLL-CSCs derived from hematopoietic stem cell (HSC)-enriched LSK population but not myeloid-granulocyte progenitors.
|
28978671 |
2017 |
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Generation of a MLL-AF9-specific stem cell model of acute monocytic leukemia.
|
27185517 |
2017 |
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This case report helps to better understand the rare but potentially severe impact of KMT2A- FLNA fusions in infants with AML to improve prognostic stratification of therapy and clinical management.
|
28253492 |
2016 |
Acute monocytic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
MicroRNA-155 is upregulated in MLL-rearranged AML but its absence does not affect leukemia development.
|
27619068 |
2016 |
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Combinatorial treatment against miR-17-5p and miR-19a-3p of the miR-17∼92 cluster dramatically reduces colony forming ability of MLL-fusion containing cell lines relative to non-MLL acute myeloid leukemia (AML) controls.
|
27123834 |
2016 |
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Outcome of allogeneic hematopoietic stem-cell transplantation for adult patients with AML and 11q23/MLL rearrangement (MLL-r AML).
|
26082270 |
2015 |
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Initiation of MLL-rearranged AML is dependent on C/EBPα.
|
24367003 |
2014 |
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Gene expression profiles of t(8;16)(p11;p13) pediatric AML cases clustered close to, but distinct from, MLL-rearranged AML.
|
23974201 |
2013 |
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The coexpression of the MLL partial tandem duplication (PTD) and the FLT3 internal tandem duplication (ITD) mutations associate with a poor outcome in cytogenetically normal acute myeloid leukemia (AML).
|
24085765 |
2013 |
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
AML with chromosomal translocations involving the mixed lineage leukemia (MLL) gene are usually associated with poor survival.
|
23798388 |
2013 |
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Both patients with IDH1 mutations had AML-M0 subtype and MLL-partial tandem duplication.
|
23365461 |
2013 |
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Concurrent presence of FLT3-internal tandem duplication (ITD) is observed in 25% of patients with MLL-PTD AML.
|
22674806 |
2012 |
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Rearrangements of the Mixed-Lineage Leukemia (MLL) gene are found in > 70% of infant leukemia, ~ 10% of adult acute myelogenous leukemia (AML), and many cases of secondary acute leukemias.
|
22160057 |
2011 |
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Prognostic significance of additional cytogenetic aberrations in 733 de novo pediatric 11q23/MLL-rearranged AML patients: results of an international study.
|
21551233 |
2011 |
Acute monocytic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In contrast, high BRE expression co-occurred strongly with FAB M5 morphology and MLL-AF9 fusions.
|
21937695 |
2011 |
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Translocations involving the mixed-lineage leukemia (MLL) gene, localized at 11q23, comprise 15 to 20% of all pediatric acute myeloid leukemia (AML) cases.
|
21566656 |
2011 |