KMT2A, lysine methyltransferase 2A, 4297

N. diseases: 535; N. variants: 65
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia
0.400 Biomarker disease BEFREE The MLL/EB1 cells grew more slowly owing to increased apoptosis in vitro and induced acute monocytic leukemia with an incomplete penetrance and longer survival in vivo. 30974389 2019
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia
0.400 Biomarker disease BEFREE Thus, a precise characterization of KMT2A-r and the fusion partner genes, especially in CKs, is of interest for managing AML. 30974445 2019
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia
0.400 Biomarker disease BEFREE Moreover, development of additional methods to detect specific translocation partners of KMT2A and leukemia-specific targeting drugs is important to improve further the outcomes of KMT2A-rearranged AML. 30869817 2019
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia
0.400 Biomarker disease BEFREE Hif-1α Deletion May Lead to Adverse Treatment Effect in a Mouse Model of MLL-AF9-Driven AML. 30595549 2019
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia
0.400 Biomarker disease BEFREE The 3-year DFS of KMT2A-rearranged AML was not significantly poorer than that of other AML (P = 0.09), and no significant difference was also seen in 3-year OS rate (P = 0.21). 31707119 2019
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia
0.400 GeneticVariation disease BEFREE Translocation (9;11)(p21.3;q23.3) is one of the most common lysine methyltransferase 2A (KMT2A)-rearrangements in <i>de novo</i> and therapy-related acute myeloid leukemia (AML). 31807181 2019
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia
0.400 Biomarker disease BEFREE C-terminal BRE might be an important contributor to this program because in a case with relapsed AML, we observed an ins(11;2) fusing CHORDC1 to BRE at the region where intragenic transcription starts in KMT2A-rearranged and KAT6A-CREBBP AML. 28871137 2018
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia
0.400 GeneticVariation disease BEFREE Among them, the translocation t(9;11)(p22;q23), KMT2A-MLLT3, is the most common abnormality accounting for approximately 22% of KMT2A rearrangements in infant AML cases. 28595195 2017
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia
0.400 Biomarker disease BEFREE A 2-year-old female with AML with MLL rearrangement presented with CNS infiltration. 28658145 2017
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia
0.400 Biomarker disease BEFREE While β-catenin has been demonstrated as an essential molecule and therapeutic target for various cancer stem cells (CSCs) including those driven by MLL fusions, here we show that transcriptional memory from cells of origin predicts AML patient survival and allows β-catenin-independent transformation in MLL-CSCs derived from hematopoietic stem cell (HSC)-enriched LSK population but not myeloid-granulocyte progenitors. 28978671 2017
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia
0.400 Biomarker disease BEFREE Generation of a MLL-AF9-specific stem cell model of acute monocytic leukemia. 27185517 2017
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia
0.400 GeneticVariation disease BEFREE This case report helps to better understand the rare but potentially severe impact of KMT2A- FLNA fusions in infants with AML to improve prognostic stratification of therapy and clinical management. 28253492 2016
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia
0.400 AlteredExpression disease BEFREE MicroRNA-155 is upregulated in MLL-rearranged AML but its absence does not affect leukemia development. 27619068 2016
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia
0.400 Biomarker disease BEFREE Combinatorial treatment against miR-17-5p and miR-19a-3p of the miR-17∼92 cluster dramatically reduces colony forming ability of MLL-fusion containing cell lines relative to non-MLL acute myeloid leukemia (AML) controls. 27123834 2016
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia
0.400 Biomarker disease BEFREE Outcome of allogeneic hematopoietic stem-cell transplantation for adult patients with AML and 11q23/MLL rearrangement (MLL-r AML). 26082270 2015
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia
0.400 Biomarker disease BEFREE Initiation of MLL-rearranged AML is dependent on C/EBPα. 24367003 2014
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia
0.400 GeneticVariation disease BEFREE Gene expression profiles of t(8;16)(p11;p13) pediatric AML cases clustered close to, but distinct from, MLL-rearranged AML. 23974201 2013
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia
0.400 GeneticVariation disease BEFREE The coexpression of the MLL partial tandem duplication (PTD) and the FLT3 internal tandem duplication (ITD) mutations associate with a poor outcome in cytogenetically normal acute myeloid leukemia (AML). 24085765 2013
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia
0.400 GeneticVariation disease BEFREE AML with chromosomal translocations involving the mixed lineage leukemia (MLL) gene are usually associated with poor survival. 23798388 2013
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia
0.400 GeneticVariation disease BEFREE Both patients with IDH1 mutations had AML-M0 subtype and MLL-partial tandem duplication. 23365461 2013
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia
0.400 Biomarker disease BEFREE Concurrent presence of FLT3-internal tandem duplication (ITD) is observed in 25% of patients with MLL-PTD AML. 22674806 2012
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia
0.400 GeneticVariation disease BEFREE Rearrangements of the Mixed-Lineage Leukemia (MLL) gene are found in > 70% of infant leukemia, ~ 10% of adult acute myelogenous leukemia (AML), and many cases of secondary acute leukemias. 22160057 2011
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia
0.400 Biomarker disease BEFREE Prognostic significance of additional cytogenetic aberrations in 733 de novo pediatric 11q23/MLL-rearranged AML patients: results of an international study. 21551233 2011
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia
0.400 AlteredExpression disease BEFREE In contrast, high BRE expression co-occurred strongly with FAB M5 morphology and MLL-AF9 fusions. 21937695 2011
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia
0.400 GeneticVariation disease BEFREE Translocations involving the mixed-lineage leukemia (MLL) gene, localized at 11q23, comprise 15 to 20% of all pediatric acute myeloid leukemia (AML) cases. 21566656 2011