|
Acute myelomonocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Identification of a Cryptic Insertion ins(11;X)(q23;q28q12) Resulting in a KMT2A-FLNA Fusion in a 13-Month-Old Child with Acute Myelomonocytic Leukemia.
|
28253492 |
2016 |
|
Acute myelomonocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We report the clinical, cytogenetic and histologic findings of a patient who presented with a de novo diagnosis of AML-M4 and who fits the profile of patients presenting with MLL alterations, such as old age at presentation, rapid progression, therapeutic refractoriness, and poor outcome.
|
19480936 |
2009 |
|
Acute myelomonocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Acute myeloid leukaemia, French-American-British M4 and M5 subtypes (AML-M4/M5) is frequently associated with MLL gene rearrangement and its incidence is relatively high among infants.
|
19120366 |
2009 |
|
Acute myelomonocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here we report the identification of a new MLL fusion partner in the case of an infant with AML-M4 and a t(11;17)(q23;q21) translocation.
|
12527918 |
2003 |
|
Acute myelomonocytic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here, we report the identification of an MLL-SEPT6 fusion transcript in an infant with acute myeloid leukemia (AML)-M4.
|
14506700 |
2003 |
|
Acute myelomonocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
While the incidence of MLL rearrangements in AML M4, M5a, and M5b was 4.7%, 33.3%, and 15.9%, respectively, it was found in only 0.9% of all other French-American-British (FAB) subtypes (P <.0001).
|
12805060 |
2003 |
|
Acute myelomonocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Southern blot analysis did not reveal any abnormality of ATM, nor of MLL, which is also located on 11q23 and is involved in t(1;11)(q21;q23) in acute myelomonocytic leukemia.
|
14499692 |
2003 |
|
Acute myelomonocytic leukemia
|
0.400 |
Biomarker
|
disease |
LHGDN |
Fusion of MLL and MSF in adult de novo acute myelomonocytic leukemia (M4) with t(11;17)(q23;q25).
|
12095151 |
2002 |
|
Acute myelomonocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
MLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia, and MLL genomic breakpoint in complex MLL-SEPTIN6 rearrangement is a DNA topoisomerase II cleavage site.
|
12096348 |
2002 |
|
Acute myelomonocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Fusion of MLL and MSF in adult de novo acute myelomonocytic leukemia (M4) with t(11;17)(q23;q25).
|
12095151 |
2002 |
|
Acute myelomonocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The CBP gene at 16p13 fuses to MOZ and MLL as a result of the t(8;16)(p11;p13) in acute (myelo)monocytic leukemias (AML M4/M5) and the t(11;16)(q23;p13) in treatment-related AML, respectively.
|
11157802 |
2001 |
|
Acute myelomonocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
This hypothesis was confirmed by the detection of deletions of the 3' regions of the CBFB and the MLL genes in AML M4 patients with inv(16) and in patients with ALL and AML associated with MLL gene translocations, respectively.
|
11369654 |
2001 |
|
Acute myelomonocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The MLL (HRX, ALL-1 HTRX) gene at chromosome band 11q23 frequently is rearranged in acute lymphoblastic and myeloblastic leukemia.
|
11477664 |
2001 |
|
Acute myelomonocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We report amplification of the MLL gene region (11q23-->11qter) in a 72-year-old woman with myelodysplastic syndrome progressing to acute myelomonocytic leukemia and in a 51-year-old man with a history of hairy cell leukemia and secondary myelodysplasia progressing to acute myelogenous leukemia.
|
11063808 |
2000 |
|
Acute myelomonocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Following the development of therapy-related leukemia after 1 year, evolution of therapy-related AML-M4 with t(11;17)(q23;q25) and the rearrangement of the MLL gene were observed, while AML/MTG8 disappeared.
|
10905055 |
2000 |
|
Acute myelomonocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In adult AML, MLL gene rearrangement was initially reported in FAB M4 and M5 cases, and recently in M1 and M2 cases, but was rare in M0 or M3 cases.
|
10846829 |
2000 |
|
Acute myelomonocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
He achieved complete remission, but developed acute myelomonocytic leukemia (AML, FAB M4) with t(9;11)(p22;q23) in March 1997 and a rearrangement of the MLL gene was also recognized.
|
9846019 |
1998 |
|
Acute myelomonocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
MLL self fusion mediated by Alu repeat homologous recombination and prognosis of AML-M4/M5 subtypes.
|
8988051 |
1997 |
|
Acute myelomonocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Southern blot analysis with a cDNA probe of MLL indicated that the breakpoint is in a BamHI 8.3 kb fragment which carries the exon 5-11 of MLL gene in DNA from an adult acute myelomonocytic leukaemia with a t(11;22) (q23;q11) translocation.
|
8616037 |
1996 |
|
Acute myelomonocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We have characterized two t(1;11)(q21;q23) translocations that fuse the MLL gene to a novel gene, AF1q on chromosomal band 1q21, in two infants with acute myelomonocytic leukemia (AMMOL).
|
7833468 |
1995 |
|
Acute myelomonocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Breakpoint heterogeneity in t(10;11) translocation in AML-M4/M5 resulting in fusion of AF10 and MLL is resolved by fluorescent in situ hybridization analysis.
|
7671224 |
1995 |
|
Acute myelomonocytic leukemia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Molecular rearrangements of the MLL gene are present in most cases of infant acute myeloid leukemia and are strongly correlated with monocytic or myelomonocytic phenotypes.
|
8282816 |
1994 |
|
Acute myelomonocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Prevalence and clinical correlations of MLL gene rearrangements in AML-M4/5.
|
7949133 |
1994 |
|
Acute myelomonocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We describe a case of acute myelomonocytic leukemia (AMML; FAB type M4) with t(10;11)(p13;q23) in which the breakpoint at 11q23 was centromeric to the MLL gene and distinct from the breakpoint seen in promyelocytic leukemias with t(11;17)(q23;q22), thus providing further evidence of heterogeneity of breakpoints in 11q23 in acute leukemia.
|
7529550 |
1994 |
|
Acute myelomonocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Acute myelomonocytic leukemia after treatment with chronic oral etoposide: are MLL and LTG9 genes targets for etoposide?
|
7948964 |
1994 |