KMT2A, lysine methyltransferase 2A, 4297

N. diseases: 535; N. variants: 65
Disease: Schizophrenia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.330 AlteredExpression disease BEFREE The results showed that blood MLL1 mRNA and BDNF exon IV on H3K4me3 levels might be involved in the psychopathology of schizophrenia. 27419650 2016
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.330 Biomarker disease BEFREE In addition, the H3K4-specific methyltransferase, MLL1, is essential for hippocampal synaptic plasticity and might be involved in cortical dysfunction of some cases of schizophrenia. 18814864 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.330 Biomarker disease PSYGENET Therefore, chromatin remodeling mechanisms at GABAergic gene promoters, including MLL1-mediated histone methylation, operate throughout an extended period of normal human PFC development and play a role in the neurobiology of schizophrenia. 17942719 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.330 Biomarker disease BEFREE Therefore, chromatin remodeling mechanisms at GABAergic gene promoters, including MLL1-mediated histone methylation, operate throughout an extended period of normal human PFC development and play a role in the neurobiology of schizophrenia. 17942719 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.330 Biomarker disease LHGDN Therefore, chromatin remodeling mechanisms at GABAergic gene promoters, including MLL1-mediated histone methylation, operate throughout an extended period of normal human PFC development and play a role in the neurobiology of schizophrenia. 17942719 2007