Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
M5b Acute differentiated monocytic leukemia
0.100 Biomarker disease BEFREE The MLL/EB1 cells grew more slowly owing to increased apoptosis in vitro and induced acute monocytic leukemia with an incomplete penetrance and longer survival in vivo. 30974389 2019
M5b Acute differentiated monocytic leukemia
0.100 Biomarker disease BEFREE Generation of a MLL-AF9-specific stem cell model of acute monocytic leukemia. 27185517 2017
M5b Acute differentiated monocytic leukemia
0.100 GeneticVariation disease BEFREE Cooperation of MLL/AF10(OM-LZ) with PTPN11 activating mutation induced monocytic leukemia with a shorter latency in a mouse bone marrow transplantation model. 27859216 2017
M5b Acute differentiated monocytic leukemia
0.100 GeneticVariation disease BEFREE A bone marrow examination confirmed the diagnosis of acute monocytic leukemia with a t(11;19) MLL-ELL fusion transcript. 19405140 2009
M5b Acute differentiated monocytic leukemia
0.100 GeneticVariation disease BEFREE The occurrence of MLL gene rearrangement in acute megakaryoblastic leukemia (AML-M7, acute myeloid leukemia, French-American-British type M7) is very rare and limited to pediatric age: in particular, MLL-MLLT10 fusion, previously reported as characteristic of monocytic leukemia, has been reported in only one case of pediatric megakaryoblastic leukemia. 16111539 2005
M5b Acute differentiated monocytic leukemia
0.100 Biomarker disease BEFREE The MYO1F, unconventional myosin type 1F, gene is fused to MLL in infant acute monocytic leukemia with a complex translocation involving chromosomes 7, 11, 19 and 22. 15897884 2005
M5b Acute differentiated monocytic leukemia
0.100 GeneticVariation disease BEFREE Here, we report a second case--an infant acute monocytic leukemia (AML M5b)--with an MLL/GRAF fusion. 15382263 2004
M5b Acute differentiated monocytic leukemia
0.100 AlteredExpression disease BEFREE MLL/SEPTIN6 chimeric transcript from inv ins(X;11)(q24;q23q13) in acute monocytic leukemia: report of a case and review of the literature. 12874781 2003
M5b Acute differentiated monocytic leukemia
0.100 GeneticVariation disease BEFREE Is t(10;11)(p11.2;q23) involving MLL and ABI-1 genes associated with congenital acute monocytic leukemia? 12547160 2002
M5b Acute differentiated monocytic leukemia
0.100 GeneticVariation disease BEFREE Fluorescence in situ hybridization (FISH) analysis in a case of infant acute monocytic leukemia M5 revealed a complex rearrangement between chromosomes 10 and 11, leading to the disruption of the MLL gene. 12127405 2002
M5b Acute differentiated monocytic leukemia
0.100 GeneticVariation disease BEFREE Analysis of MLL-derived transcripts in infant acute monocytic leukemia with a complex translocation (1;11;4)(q21;q23;p16). 10700861 2000
M5b Acute differentiated monocytic leukemia
0.100 GeneticVariation disease BEFREE Molecular analysis of the rearranged genome and chimeric mRNAs caused by the t(6;11)(q27;q23) chromosome translocation involving MLL in an infant acute monocytic leukemia. 10719372 2000
M5b Acute differentiated monocytic leukemia
0.100 GeneticVariation disease BEFREE Cytogenetic and molecular analysis of the acute monocytic leukemia cell line THP-1 with an MLL-AF9 translocation. 11066077 2000
M5b Acute differentiated monocytic leukemia
0.100 GeneticVariation disease BEFREE The mixed lineage leukemia (MLL) gene located at chromosome band 11q23 is frequently rearranged in patients with therapy-related acute monocytic leukemia who received topoisomerase II inhibitors. 10648423 2000
M5b Acute differentiated monocytic leukemia
0.100 GeneticVariation disease BEFREE Of 16 acute myeloid leukemia patients with trisomy 11 and rearrangement of MLL reported, our patient was the youngest in age and the only one with AMoL. 9209466 1997
M5b Acute differentiated monocytic leukemia
0.100 GeneticVariation disease BEFREE Two acute monocytic leukemia (AML-M5a) cell lines (MOLM-13 and MOLM-14) with interclonal phenotypic heterogeneity showing MLL-AF9 fusion resulting from an occult chromosome insertion, ins(11;9)(q23;p22p23). 9305600 1997
M5b Acute differentiated monocytic leukemia
0.100 Biomarker disease BEFREE Rearrangements of the human trithorax gene (MLL, HRX, Htrx-1, All-1) were studied by Southern blotting in blast cells stored at presentation from 65 adults with de novo acute myelomonocytic (AML-M4) and acute monocytic leukemia (AML-M5). 7949133 1994
M5b Acute differentiated monocytic leukemia
0.100 GeneticVariation disease BEFREE A case of acute monocytic leukemia with t(11;17) involving a rearrangement of MLL-1 and a region proximal to the RARA gene. 8194047 1994
M5b Acute differentiated monocytic leukemia
0.100 GeneticVariation disease BEFREE In the present study, we isolated chimeric cDNAs between the MLL and a gene designated MLLT3 at 9p22 from a cDNA library of an IMS-M1 cell line with a t(9;11)(p22;q23) translocation, a representative karyotypic abnormality seen in acute monocytic leukemia. 8414510 1993