|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Then, cells from each population were retrovirally transduced to initiate MLL-AF9 acute myelogenous leukemia (AML) and the intracellular domain of NOTCH-1 T-cell acute lymphoblastic leukemia (T-ALL).
|
30733302 |
2019 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Zinc finger protein X-linked (ZFX) is a key regulator of both embryonic stem cells (ESCs) and hematopoietic stem cells (HSCs), which is required for both Notch intracellular domain (NotchIC)-induced acute T-cell leukemia and MLL-AF9-induced myeloid leukemia in mouse models.
|
27797721 |
2016 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
They act as dominant cooperating oncoproteins that cause acute leukemias bearing MLL translocations and to a lesser extent T-cell acute lymphocytic leukemia (ALL) characterized by other gene fusions.
|
26059450 |
2015 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A higher specific hazard of relapse was independently associated with postinduction MRD level ≥10(-4) and unfavorable genetic characteristics (ie, MLL gene rearrangement or focal IKZF1 gene deletion in BCP-ALL and no NOTCH1/FBXW7 mutation and/or N/K-RAS mutation and/or PTEN gene alteration in T-cell ALL).
|
24740809 |
2014 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MLL gene rearrangement is a new subgroup concerned with prognosis in T-ALL/LBL.
|
22710816 |
2012 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The 89 older adolescents were significantly more likely to have T-cell ALL, the t(4;11)(MLL-AF4), and detectable minimal residual disease during or at the end of remission induction; they were less likely to have the t(12;21)(ETV6-RUNX1) compared with younger patients.
|
21172890 |
2011 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MLL-rearranged and non-MLL-rearranged precursor B-cell and T-cell acute lymphoblastic leukemias.
|
20494936 |
2010 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results suggest that NOTCH1 and MLL abnormalities are primary leukemogenic hits in early T-ALL.
|
19631984 |
2010 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The LAF4 gene is a member of the AF4/FMR2 family and was previously identified as a fusion partner of MLL in B-precursor ALL with t(2;11)(q11;q23), although AML1-LAF4 was in T-ALL.
|
17968322 |
2008 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Since the NF1 protein is a negative regulator of the RAS pathway (RAS-GTPase activating protein), homozygous NF1 inactivation represent a novel type I mutation in pediatric MLL-rearranged AML and T-ALL with a predicted frequency that is less than 10%.
|
18172006 |
2008 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Gene expression studies have shown distinct subtypes of LYL1+, HOX11+, TAL1+, and MLL+ pre-T ALL/LBL.
|
17369128 |
2007 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Fluorescence in-situ hybridization (FISH) analysis showed the AML to be of donor origin (i.e., karyotypically female) with an 11q23 (mixed lineage leukemia (MLL) gene) translocation, while the original T-ALL exhibited a male karyotype with abnormalities of chromosomes 6, 8, and a t(10;14)(q24;q11.2).
|
16493618 |
2006 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical validation of protein expression of selected genes identified by microarray analysis confirmed overexpression of MLL-1 in T-LL tumor cells compared to T-ALL and CD47 in T-ALL tumors cells when compared to T-LL.
|
16358311 |
2006 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Two rare cases of pro-T ALL with MLL+ve were found.
|
16261608 |
2006 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There are numerous known genetic prognostic variables in ALL, which include T cell ALL, the hyperdiploid karyotype and the translocations: t(12;21)[TEL-AML1], t(4;11)[MLL-AF4], t(9;22)[BCR-ABL], and t(1;19)[E2A-PBX].
|
15387886 |
2004 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We established a novel myeloid cell line, SN-1, from a patient with T-cell acute lymphoblastic leukemia with t(11;16)(q23;p13) having in-frame MLL-CBP fusion transcripts.
|
10706136 |
2000 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Reverse transcriptase-polymerase chain reaction (RT-PCR) using an MLL sense primer and an AF6 antisense primer detected the MLL/AF6 fusion cDNA from three leukemia patients with the t(6;11) [two AML and one T-acute lymphoblastic leukemia (ALL)] and one cell line.
|
8703846 |
1996 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here a novel structural alteration of the ALL-1 gene was observed in three patients presenting with acute T-cell leukemia (ALL) without chromosomal translocations or self-fusions of the ALL-1 gene.
|
8616868 |
1996 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We recently detected an MLL gene rearrangement in a patient with typical T-cell ALL (CD2+, CD4+, CD5+, CD7+, CD8+, HLA DR-) and an apparently normal karyotype (46,XX).
|
8527389 |
1995 |