|
Infant Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We established a reporter system to systematically quantitate and stratify the potential for such compounds to promote chromosomal translocations between the MLL and AF9 bcrs analogous to those in infant leukemia.
|
30387535 |
2019 |
|
Infant Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Excess congenital non-synonymous variation in leukemia-associated genes in MLL- infant leukemia: a Children's Oncology Group report.
|
24301523 |
2014 |
|
Infant Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Because of the unfavorable outcome associated with MLL rearrangements in infant leukemia, we intensified postremission treatment according to the Interfant-06 study protocol.
|
24635731 |
2014 |
|
Infant Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The mixed lineage leukemia (MLL) gene is commonly rearranged in infant leukemia (IL).
|
22422485 |
2013 |
|
Infant Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This review highlights the key clinical, pathologic, and epidemiologic features of infant leukemia, including the high frequency of mixed lineage leukemia (MLL) gene rearrangements.
|
24319237 |
2013 |
|
Infant Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
MLL gene rearrangements in infant leukemia vary with age at diagnosis and selected demographic factors: a Children's Oncology Group (COG) study.
|
21800415 |
2012 |
|
Infant Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Rearrangements of the Mixed-Lineage Leukemia (MLL) gene are found in > 70% of infant leukemia, ~ 10% of adult acute myelogenous leukemia (AML), and many cases of secondary acute leukemias.
|
22160057 |
2011 |
|
Infant Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nebulette is the second member of the nebulin family fused to the MLL gene in infant leukemia.
|
20362230 |
2010 |
|
Infant Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The clinical features and molecular analyses for the fusion transcripts of mixed lineage leukemia (MLL) gene rearrangement in infant leukemia have not been well documented in the Chinese population.
|
20979094 |
2010 |
|
Infant Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
MLL rearrangements are hallmark genetic abnormalities in infant leukemia known to arise in utero.
|
19587093 |
2009 |
|
Infant Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Outcome of recurrent or refractory acute lymphoblastic leukemia in infants with MLL gene rearrangements: A report from the Japan Infant Leukemia Study Group.
|
19229974 |
2009 |
|
Infant Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
MLL associated leukemias account for the majority of infant leukemia, approximately 10% of adult de novo leukemia and approximately 33% of therapy related acute leukemia with a balanced chromosome translocation.
|
19729989 |
2009 |
|
Infant Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Infant leukemia (IL) is characterised by the presence of MLL rearrangements and a poor outcome.
|
19052976 |
2008 |
|
Infant Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Infant leukemia associated with rearrangement of the MLL gene typically presents with high-risk clinical features.
|
19131787 |
2008 |
|
Infant Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Definitive diagnosis of coexisting pro-B cell infant leukemia with cryptic MLL rearrangement was delayed by the transient regeneration of normal hematopoiesis and reduction of abnormal blastoid cells in the bone marrow following immunoglobulin administration.
|
16814860 |
2007 |
|
Infant Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Molecular characterization of a rare MLL-AF4 (MLL-AFF1) fusion rearrangement in infant leukemia.
|
17889710 |
2007 |
|
Infant Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Other variables of interest were not notably associated with infant leukemia regardless of MLL status.
|
17220341 |
2007 |
|
Infant Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Infants with acute lymphoblastic leukemia and a germline MLL gene are highly curable with use of chemotherapy alone: results from the Japan Infant Leukemia Study Group.
|
16478880 |
2006 |
|
Infant Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
MLL chimeric protein activation renders cells vulnerable to chromosomal damage: an explanation for the very short latency of infant leukemia.
|
16688745 |
2006 |
|
Infant Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, whereas the genomic breakpoints in MLL tend to cluster in the 5' portion of the 8.3 kb breakpoint cluster region (BCR) in de novo and adult patients and in the 3' portion in infant leukemia patients and t-AML patients, those in both the AML1 and ETO genes occur in the same clustered regions in both de novo and t-AML patients.
|
16893685 |
2006 |
|
Infant Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Leukemias with MLL translocations have been the topic of intense interest because of the unusual, biphenotypic immunophenotype of these leukemias, because of the unique clinical presentation of some MLL translocations (infant leukemia and therapy-related leukemia), and because of the large number of different chromosomal loci that partner with MLL in these translocations.
|
16797254 |
2006 |
|
Infant Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Analysis of the outcome among ALL infants with MLL gene rearrangements registered in the Japan Infant Leukemia Study between 1996 and 1999 showed the event-free survival of patients with t(9;11) was not different from that of those with other 11q23 translocations.
|
16158826 |
2005 |
|
Infant Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In previous studies, genotypes conferring lower NQO1 activity have been associated with an increased risk of acute leukemia, particularly infant leukemia carrying MLL/AF4 fusion genes.
|
15590400 |
2004 |
|
Infant Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
This report demonstrates that chromosomal insertion of MLL sequences is a rare but recurrent abnormality associated with infant leukemia.
|
12759932 |
2003 |
|
Infant Leukemia
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
The role of the MLL gene in infant leukemia.
|
14704031 |
2003 |