Chronic Obstructive Airway Disease
|
0.900 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
Chronic Obstructive Airway Disease
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
The up-regulation of MMP1 and MMP9 was the main change associated with COPD.
|
20970515 |
2011 |
Chronic Obstructive Airway Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in MMP2 and MMP9 but not in MMP1 and MMP12 are associated with the risk of COPD in the Mexican mestizo population.
|
26439471 |
2015 |
Chronic Obstructive Airway Disease
|
0.900 |
Biomarker
|
disease |
BEFREE |
In contrast, 8/12 genes (early growth response factor 1, MMP1, MMP9, MMP10, plasminogen activator urokinase, plasminogen activator urokinase receptor, tumor necrosis factor, and IL13) increased and 4/12 (MMP2, tissue inhibitor of matrix metalloproteinase-1, collagen 1alpha1, and transforming growth factor-beta3) decreased in the surrounding lung tissue in association with progression of COPD.
|
20075389 |
2010 |
Chronic Obstructive Airway Disease
|
0.900 |
Biomarker
|
disease |
HPO |
|
|
|
Chronic Obstructive Airway Disease
|
0.900 |
Biomarker
|
disease |
BEFREE |
SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD.
|
24039251 |
2013 |
Chronic Obstructive Airway Disease
|
0.900 |
AlteredExpression
|
disease |
LHGDN |
Activation of the MMP-1 promoter by cigarette smoke in human small airway epithelial cells requires ERK MAP kinase signaling: differential response of the 1G and 2G promoter sequences.
|
16921115 |
2006 |
Chronic Obstructive Airway Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
In this report, we performed Meta analysis to investigate the association between four kinds of MMP single nucleotide polymorphisms (SNP, MMP1 -1607 1G/2G, MMP3 -1171 5A/6A, MMP9 -1562 C/T, MMP12 -82 A/G) and COPD risk from 21 studies including 4184 cases and 5716 controls.
|
24085258 |
2013 |
Chronic Obstructive Airway Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in MMP1 were not consistently associated with prevalent COPD or incident NSCLC nor with survival in NSCLC.
|
22993337 |
2012 |
Chronic Obstructive Airway Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Here we review evidence that genetic polymorphisms in matrix metalloproteinase genes MMP1, MMP9 and MMP12 may be important in the development of COPD.
|
12383023 |
2002 |
Chronic Obstructive Airway Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
When stratified by ethnicity, results indicated MMP-1 -1607G/GG (recessive model: G/G vs G/GG+GG/GG; OR: 1.20; 95% CI: 1.01-1.44; p = 0.04) and MMP-9 -1562 C/T (dominant model; OR: 1.66; 95% CI: 1.01-2.71; p = 0.04) were correlated with COPD susceptibility among Caucasians and Asians respectively.
|
23555986 |
2013 |
Chronic Obstructive Airway Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
We also found that the chronic obstructive pulmonary disease (COPD)-predisposing TRPV4P19S variant enhances Ca2+ influx and MMP 1 activation, providing mechanistic linkage between man-made air pollution and human airway disease.
|
21245013 |
2011 |
Chronic Obstructive Airway Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
However, MMP-1 rs1799750 1G > 2G and MMP-3 rs3025058 5A > 6A were not associated with COPD risk (all P > 0.05).
|
27173221 |
2016 |
Chronic Obstructive Airway Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
No significant associations were found between genetic variations in MMP-1 and MMP-2 variants and the risk of development of COPD.
|
27412345 |
2016 |
Chronic Obstructive Airway Disease
|
0.900 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
Chronic Obstructive Airway Disease
|
0.900 |
Biomarker
|
disease |
CTD_human |
|
|
|
Chronic Obstructive Airway Disease
|
0.900 |
Biomarker
|
disease |
RGD |
The MMP-1 mRNA expression level was obviously higher in the COPD of CDS group than in the COPD model group (P < 0.01).
|
23173262 |
2012 |
Chronic Obstructive Airway Disease
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
TLR4 protein contributes to cigarette smoke-induced matrix metalloproteinase-1 (MMP-1) expression in chronic obstructive pulmonary disease.
|
21730072 |
2011 |
Chronic Obstructive Airway Disease
|
0.900 |
Biomarker
|
disease |
BEFREE |
Serum levels of MMP-1,-7,-10-12 were significantly influenced by smoking, and MMP-1, -3, -7 and-12 were elevated in subjects with COPD and carotid plaque.
|
30789935 |
2019 |
Chronic Obstructive Airway Disease
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
To investigate the association of 3 polymorphisms of MMP genes (MMP-1 -1607G-->GG, MMP-9 -1562C-->T and MMP-12 N357S), which have been reported to be associated with COPD-related phenotypes, with the risk of COPD in a Korean population.
|
20160424 |
2010 |
Hallopeau-Siemens Disease
|
0.630 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
Hallopeau-Siemens Disease
|
0.630 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
Hallopeau-Siemens Disease
|
0.630 |
GermlineModifyingMutation
|
disease |
ORPHANET |
|
|
|
Hallopeau-Siemens Disease
|
0.630 |
GeneticVariation
|
disease |
BEFREE |
An investigation into the MMP1 gene promoter region polymorphism--1607 2G with recessive dystrophic epidermolysis bullosa disease severity in northeastern Mexican patients.
|
24899116 |
2014 |
Hallopeau-Siemens Disease
|
0.630 |
Biomarker
|
disease |
BEFREE |
Type VII collagen is a substrate of MMP1 and an imbalance between its synthesis and degradation could conceivably worsen the RDEB phenotype.
|
18030675 |
2008 |