|
Dysplastic Nevus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This study analyzed the expression of MMP-1, MMP-2, and MMP-13 proteins in primary nodular melanoma (NM) and dysplastic nevi (DN) as a significant risk factor for melanoma development.
|
31677173 |
2020 |
|
Papillary thyroid carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This research retrospectively investigates the expression of MMP-1, -2 and -9 as well as TIMP-1 and -2 in papillary thyroid carcinoma tissue.
|
31646745 |
2020 |
|
acute aortic dissection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Pooled analyses demonstrated no significant differences in MMP-1 (4 studies; P = 0.21), MMP-2 (5 studies; P = 0.62) and MMP-3 levels (2 studies; P = 0.94) between AAD patients and control subjects; and significantly higher MMP-8 (2 studies; SMD 2.11; P = 0.020), MMP-9 (9 studies; SMD 1.54; P < 0.001) and MMP-12 levels (2 studies; SMD 1.33; P < 0.001) in AAD patients than in control subjects.
|
31808522 |
2020 |
|
Degeneration of lumbar intervertebral disc
|
0.010 |
Biomarker
|
disease |
BEFREE |
Immuohistochemical score of matrix metalloproteinase-1 may indicate the severity of symptomatic cervical and lumbar disc degeneration.
|
31408735 |
2020 |
|
Amputated structure (morphologic abnormality)
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We determined the systemic and local release of MMP-1, -2, -3, -9, TIMP-1, and TIMP-2 by enzyme linked immunosorbent assay (ELISA) technique and their influences in the healing process in 26 patients who underwent minor amputation after a successful revascularisation procedure.
|
31657109 |
2020 |
|
Arthralgia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
There was a significant increase in interleukin (IL)-1<i>β</i>, IL-6, IL-8, monocyte chemotactic protein-1 (MCP-1), MMP-1, and MMP-3 levels in patients with persistent arthralgia in comparison to healthy controls (<i>p</i> < 0.05) and a significant increase in tumor necrosis factor-alpha (TNF-<i>α</i>), MMP-1, and MMP-3 levels in patients with persistent arthralgia in comparison to patients who had fully recovered (<i>p</i> < 0.05).
|
31718485 |
2019 |
|
Bladder neck obstruction
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of MMP-1 was significantly decreased accompanying with increased TIMP-1 expression in BOO rats compared with that in Sham rats, which was ameliorated by SFN treatment.
|
31316719 |
2019 |
|
Malignant neoplasm of larynx
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Result:</b> The effective adhesion rate of MB<sub>MMP-1</sub> and MB<sub>IgG</sub> to HEp-2 was 298.42 ± 16.57 versus 12.38 ± 3.26 bubbles/per field <i>in vitro</i> experiment, which shows a significant difference (<i>P</i> < 0.01).
|
31275143 |
2019 |
|
Cryptorchidism
|
0.010 |
Biomarker
|
disease |
BEFREE |
There were no significant differences in the levels of inhibin B in the group of boys with cryptorchidism and boys with inguinal hernia and it also did not correlate with MMP-1 and MMP-2 concentrations.
|
31295049 |
2019 |
|
Leukemia, Myelocytic, Acute
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Decreased MMP1 gene expression in AML similar to that of MMP9, shows a greater role for MMP1 in normal haematopoiesis than in the development of leukaemic cells.
|
30747385 |
2019 |
|
Rectal Prolapse
|
0.010 |
Biomarker
|
disease |
BEFREE |
MMP-1/TIMP-1 expressions in rectal submucosa of females with obstructed defecation syndrome associated with internal rectal prolapse.
|
30221334 |
2019 |
|
Urinary tract infection
|
0.010 |
Biomarker
|
group |
BEFREE |
MMP-1-3, MMP-7-10, and MMP-12-13 were analyzed in serum from women who had spontaneous abortion of unknown causes (n = 7), who suffered abortions attributed to urinary tract infection (n = 7) and from those with healthy pregnancies without complications (controls; n = 20).
|
30885072 |
2019 |
|
Deep Vein Thrombosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, monitoring the concentration of MMP-1, MMP-2 and inflammatory factors is of significant value for the diagnosis, progression and judgement of treatment effect of DVT in clinical practice.
|
30651780 |
2019 |
|
Rheumatic mitral regurgitation
|
0.010 |
Biomarker
|
disease |
BEFREE |
There was increased MMP-1 activity as the MMP-1-to- TIMP-1 ratio was higher in CRMR patients compared to the controls ( -1.2 ± 0.6 vs -2.1 ± 0.89, p = 0.002).
|
29443354 |
2019 |
|
Lichen Planus, Oral
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Effect of a structured plaque control on MMP-1 and MMP-9 crevicular levels in patients with desquamative gingivitis associated with oral lichen planus.
|
30327948 |
2019 |
|
Recurrent urinary tract infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
MMP-1-3, MMP-7-10, and MMP-12-13 were analyzed in serum from women who had spontaneous abortion of unknown causes (n = 7), who suffered abortions attributed to urinary tract infection (n = 7) and from those with healthy pregnancies without complications (controls; n = 20).
|
30885072 |
2019 |
|
Idiopathic guttate hypomelanosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MMP-1 expression was significantly higher in the lesions of IGH and type IV collagen was significantly degraded in the basement membrane zone of IGH lesions.
|
31823346 |
2019 |
|
Squamous cell carcinoma of oropharynx
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association of polymorphisms in IL-8, MMP-1 and MMP-13 with the risk and prognosis of oral and oropharyngeal squamous cell carcinoma.
|
31525531 |
2019 |
|
Deep vein thrombosis of lower limb
|
0.010 |
Biomarker
|
disease |
BEFREE |
Expression variations and clinical significance of MMP-1, MMP-2 and inflammatory factors in serum of patients with deep venous thrombosis of lower extremity.
|
30651780 |
2019 |
|
Urethral intrinsic sphincter deficiency
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Still, MMP1 and MMP9 exhibited a tendency to a higher expression in women with ISD.
|
31099099 |
2019 |
|
Oropharyngeal disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
No associations between rs4073 in IL-8 and rs2071230 and rs470558 in MMP-1 were observed, but rs2252070 in MMP-13, in the dominant model, was associated in a protective manner to oral and oropharyngeal SCC (OR: 0.20, 95% CI: 0.06-0.71, p = 0.007).
|
31525531 |
2019 |
|
Carcinoma of larynx
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Result:</b> The effective adhesion rate of MB<sub>MMP-1</sub> and MB<sub>IgG</sub> to HEp-2 was 298.42 ± 16.57 versus 12.38 ± 3.26 bubbles/per field <i>in vitro</i> experiment, which shows a significant difference (<i>P</i> < 0.01).
|
31275143 |
2019 |
|
Infarction, Middle Cerebral Artery
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High serum levels of tissue inhibitor of matrix metalloproteinase-1 during the first week of a malignant middle cerebral artery infarction in non-surviving patients.
|
31319804 |
2019 |
|
Diabetic wound
|
0.010 |
Biomarker
|
disease |
BEFREE |
Effect of Horse-chestnut seed extract on matrix metalloproteinase-1 and -9 during diabetic wound healing.
|
31353546 |
2019 |
|
Diabetic Nephropathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
2G allele of MMP-1, C allele of MMP-2 and 5A/6A genotype of MMP-3 were associated with susceptibility and disease progression of type 2 DN and might be used as potential markers for risk prediction and prognosis of type 2 DN.
|
29883760 |
2018 |