|
Retinitis Pigmentosa
|
0.010 |
Biomarker
|
disease |
BEFREE |
Compared with those in the control group, the aqueous humor levels of monocyte chemoattractant protein-1 (MCP-1), interleukin-(IL-)8, interferon gamma-induced protein (IP)-10, hepatocyte growth factor (HGF), platelet-derived growth factor AA (PDGF-AA), matrix metalloproteinase-2 (MMP-2), MMP3, MMP-7, MMP-8, plasminogen activator inhibitor-1 (PAI-1), and thrombospondin-2 (TSP-2) in the RP group increased significantly (P < 0.01).
|
31810025 |
2020 |
|
Tuberculosis, Meningeal
|
0.010 |
Biomarker
|
disease |
BEFREE |
The concentrations of matrix metalloproteinase 9 (MMP-9), MMP-2, tissue inhibitor of metalloproteinase 1 (TIMP-1), and TIMP-2 were significantly elevated in the lumbar CSF samples, and we found interesting dynamics for MMP-9 that offer novel insight into its role in pediatric patients with tuberculous meningitis.
|
30753686 |
2020 |
|
Dysplastic Nevus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Immunohistochemistry for MMP-1, MMP-2, and MMP-13 was performed on nodular melanoma (n = 52) and dysplastic nevi (n = 28) on tissue microarray (TMA).
|
31677173 |
2020 |
|
acute aortic dissection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Pooled analyses demonstrated no significant differences in MMP-1 (4 studies; P = 0.21), MMP-2 (5 studies; P = 0.62) and MMP-3 levels (2 studies; P = 0.94) between AAD patients and control subjects; and significantly higher MMP-8 (2 studies; SMD 2.11; P = 0.020), MMP-9 (9 studies; SMD 1.54; P < 0.001) and MMP-12 levels (2 studies; SMD 1.33; P < 0.001) in AAD patients than in control subjects.
|
31808522 |
2020 |
|
Nodular melanoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This study analyzed the expression of MMP-1, MMP-2, and MMP-13 proteins in primary nodular melanoma (NM) and dysplastic nevi (DN) as a significant risk factor for melanoma development.
|
31677173 |
2020 |
|
Intermittent divergent squint
|
0.010 |
Biomarker
|
disease |
BEFREE |
MMP-2 showed a positive correlation with angle of deviation at distance and at near, age at surgery and duration of IXT (p = 0.000, p = 0.000, p = 0.000, p = 0.022, respectively, Spearman's rank correlation analysis).
|
31421016 |
2020 |
|
Central visual impairment
|
0.010 |
Biomarker
|
disease |
BEFREE |
The SDX-induced improvement of contraction and restoration of vein function appear to involve decreases in MMP-2 and MMP-9 and may contribute to the benefits of SDX in CVI and VVs.
|
31738197 |
2020 |
|
Hypertrophic obstructive cardiomyopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Procollagen type I carboxy-terminal propeptide (PICP) and MMP-2 are potential biomarkers of myocardial fibrosis in patients with hypertrophic cardiomyopathy.
|
31639652 |
2020 |
|
Acne Vulgaris
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Although no association was found between the TIMP-2 (-418G/C) polymorphism and the acne vulgaris, patients with the MMP-2 CT/TIMP-2 GG or GC allele are at higher risk of acne vulgaris.
|
31032338 |
2019 |
|
Acute pancreatitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
MMP-2 and MMP-9 gene polymorphisms act as biological indicators for ulinastatin efficacy in patients with severe acute pancreatitis.
|
31192912 |
2019 |
|
Extrinsic allergic alveolitis
|
0.010 |
AlteredExpression
|
group |
BEFREE |
<i>MMP2</i> Polymorphism Affects Plasma Matrix Metalloproteinase (MMP)-2 Levels, and Correlates with the Decline in Lung Function in Hypersensitivity Pneumonitis Positive to Autoantibodies Patients.
|
31590404 |
2019 |
|
Aneurysm, Dissecting
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Local IL-1β might participate in the formation of aortic DA through the upregulation of MMP-2 and MMP-9 and the breakage of elastin fibres, which finally weakens the biomechanical properties of the aortic wall.
|
30169834 |
2019 |
|
Bloom Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, KP‑13 downregulated the expression levels of tumor necrosis factor‑α, TGF‑β, collagen type I α1, actin α2 and matrix metalloproteinase 2 in BLM‑treated lungs compared with BLM group.
|
31173221 |
2019 |
|
Cerebral Palsy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that growth differentiation factor 6 and hepatocyte growth factor (HGF) were significantly downregulated, whereas TGFβ and matrix metalloproteinase-2 were significantly upregulated in CP-MSCs compared with H-MSCs, among 84 MSC-related genes investigated in this study.
|
30680957 |
2019 |
|
Cholesteatoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Effect of CT manifestations of cholesteatoma on MMP-2, MMP-9 and IL-6 in the serum of patients.
|
31086579 |
2019 |
|
Cryptorchidism
|
0.010 |
Biomarker
|
disease |
BEFREE |
There were no significant differences in the levels of inhibin B in the group of boys with cryptorchidism and boys with inguinal hernia and it also did not correlate with MMP-1 and MMP-2 concentrations.
|
31295049 |
2019 |
|
Hereditary Factor XIII Deficiency
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Expression and CpG island methylation pattern of MMP-2 and MMP-9 genes in patients with congenital factor XIII deficiency and intracranial hemorrhage.
|
31469059 |
2019 |
|
IGA Glomerulonephritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the comparison between IgAN and controls, IgAN glomeruli showed significantly higher abundance of extracellular matrix structural proteins (e.g periostin, vitronectin, and extracellular matrix protein 1) and extracellular matrix associated proteins (e.g. azurocidin, myeloperoxidase, neutrophil elastase, matrix metalloproteinase-9 and matrix metalloproteinase 2).
|
31726998 |
2019 |
|
Irritable Bowel Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Long Non-Coding RNA GAS5 and Intestinal MMP2 and MMP9 Expression: A Translational Study in Pediatric Patients with IBD.
|
31652976 |
2019 |
|
Ocular Larva Migrans
|
0.010 |
Biomarker
|
disease |
BEFREE |
Matrix metalloproteinase-2 and matrix metalloproteinase-9 in mice with ocular toxocariasis.
|
30631927 |
2019 |
|
Otitis Media
|
0.010 |
Biomarker
|
disease |
BEFREE |
Effect of CT manifestations of cholesteatomatous otitis media on matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) and interleukin-6 (IL-6) in the serum of patients was investigated.
|
31086579 |
2019 |
|
Pain, Postoperative
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Together, the above results reveal that upregulated MMP-9 via p38/IL-1β and MMP-2 via Erk/IL-1β signaling in the wounded tissue, ipsilateral DRG, and dorsal horn contribute to the development of postoperative pain.
|
31075261 |
2019 |
|
Respiratory Distress Syndrome, Adult
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, CXCL5 neutralizing antibody effectively alleviated inflammatory response, diffuse alveolar damage, and pulmonary edema, and decreased the expression levels of MMP2 and MMP9 compared to LPS-induced ARDS.
|
31311916 |
2019 |
|
Tetralogy of Fallot
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Patients with repaired TOF had significantly higher levels of TGF-β1 (p = 0.005), MMP-2 (p = 0.001) and MMP-9 (p < 0.001) than controls, while patients after atrial switch operation (p = 0.034) and Fontan procedures (p < 0.001) had higher MMP-2 levels.
|
30655554 |
2019 |
|
Spina Bifida
|
0.010 |
Biomarker
|
disease |
BEFREE |
Urinary TIMP-2 and MMP-2 are significantly associated with poor bladder compliance in adult patients with spina bifida.
|
31486131 |
2019 |