Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration
0.080 GeneticVariation disease BEFREE GA + AA genotypes of rs243866 SNP may associate with a decreased risk of AMD in the age≤65 years subgroup (P = .028, OR = 0.399, 95% CI = 0.174-0.915).MMP-2 gene rs243865 and rs243866 SNPs associated with the risk of AMD. 29381911 2017
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration
0.080 GeneticVariation disease BEFREE The role of MMP2 (-1306C>T) and TIMP2 (-418 G>C) promoter variants in age-related macular degeneration. 23536957 2013
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration
0.080 GeneticVariation disease BEFREE The analysis of the MMP-2 (-1306 C/T) gene polymorphism did not reveal any differences in the genotype distribution between the patients with AMD and the control subjects. 26333112 2016
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration
0.080 GeneticVariation disease BEFREE The MMP-2 (-1306 C>T) promoter variant is unlikely to have a major role in AMD risk susceptibility. 30845235 2019
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration
0.080 GeneticVariation disease BEFREE The frequency of the MMP-2 (-735) C/T and MMP-3 (-1171) 5A/6A genotypes did not differ significantly between the patients with AMD and the control group, while the MMP-9 (-1562) C/C genotype was more frequently detected in patients with AMD than the control group (73.7% vs. 64.6%, p=0.048). 24079541 2015
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration
0.080 Biomarker disease BEFREE The localization of MMP-2 and MMP-9 to the areas of new vessel formation and to the enveloping Bruch's-like membrane, respectively, suggests that MMP-2 and MMP-9 may be cooperatively involved in the progressive growth of choroidal neovascular membranes in AMD. 9761302 1998
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration
0.080 GeneticVariation disease BEFREE No association between <i>MMP-2 (-1306 C/T)</i> gene polymorphism in patients with atrophic AMD and control group was found (54.94%, 37.64%, 7.41% <i>vs</i> 50%, 38.24%, 11.76%; <i>P</i>=0.6). 28944191 2017
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration
0.080 GeneticVariation disease BEFREE The role of MMP2 rs2287074 in ARM should be further elucidated. 18359774 2008