|
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Matrix metalloproteinase 2-negative glioblastomas exhibited significantly reduced activated leukocyte adhesion molecule expression levels compared with astrocytomas.
|
22304788 |
2012 |
|
Glioblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This prospective, case control study was aimed to find out an association of MMP-2 gene polymorphism with susceptibility to develop glioblastoma in Indian population.
|
21483125 |
2011 |
|
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
By virtue of its restricted expression in GBM and its role in invasion, Necl-5 may be an attractive target for limiting MMP-2 production in glioblastoma, and therefore limiting dispersal.
|
20680398 |
2011 |
|
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The effect of different doses of X(-)rays on apoptosis, proliferation, epidermal growth factor receptor (EGFR) and matrix metalloproteinase (MMP-2) expression was investigated in a human glioblastoma cell line.
|
21289335 |
2011 |
|
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Consistent with this idea, 39% less extracellular MMP2 was measured from knockdown cells identifying one mechanism by which calpain 2 mediates glioblastoma cell invasion.
|
20730561 |
2010 |
|
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Together, our data strongly suggest that LRP1 promotes glioblastoma cell migration and invasion by regulating the expression and function of MMP2 and MMP9 perhaps via an ERK-dependent signaling pathway.
|
19176371 |
2009 |
|
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Together, our data strongly suggest that LRP1 promotes glioblastoma cell migration and invasion by regulating the expression and function of MMP2 and MMP9 perhaps via an ERK-dependent signaling pathway.
|
19176371 |
2009 |
|
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This cannabinoid-induced inhibition of MMP-2 expression in gliomas (a) was MMP-2-selective, as levels of other MMP family members were unaffected; (b) was mimicked by JWH-133, a CB(2) cannabinoid receptor-selective agonist that is devoid of psychoactive side effects; (c) was abrogated by fumonisin B1, a selective inhibitor of ceramide biosynthesis; and (d) was also evident in two patients with recurrent glioblastoma multiforme.
|
18339876 |
2008 |
|
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here, we show that siRNA delivery significantly decreased levels of MMP-2 in the glioblastoma cell lines U-87 and U-251.
|
18438431 |
2008 |
|
Glioblastoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Inhibition of matrix degrading enzymes and invasion in human glioblastoma (U87MG) cells by isoflavones.
|
16598420 |
2006 |
|
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the expression of MMP-2, its inhibitor TIMP-2 and the tumour invasiveness-related protein SPARC were effectively inhibited by TRAIL in glioblastoma cell lines.
|
16622457 |
2006 |
|
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In this study we used RT-PCR, western blot and SDS-zymography to investigate the effect of resveratrol on the expression of genes and proteins involved in the extracellular matrix remodeling associated with tumor invasion in human cultured glioblastoma cells treated for 24, 48 and 72 h. We analyzed the expression of matrix metalloproteinase-2 (MMP-2), the main mediator of glioblastoma invasiveness, and the Secreted Protein Acidic and Rich in Cysteine (SPARC), involved in the regulation of cell-matrix interactions.
|
16084059 |
2005 |
|
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Similarly, U87MG cells engineered to overexpress TIMP-2 at the same levels as U87-C1 cells also demonstrated increased MMP-2 activation, indicating that an increase in physiological levels of TIMP-2 can promote MMP-2 activation and invasion in glioblastoma cells.
|
14631378 |
2004 |
|
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The expression of these MMPs was markedly increased in most GBMs with excellent correlation between mRNA and protein levels; activated forms of MMP-2 and MMP-9 were present in 8/18 and 7/18 of GBMs.
|
12918061 |
2003 |
|
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Finally, tissue microarray analysis of 68 GBM tissue specimens showed a significant correlation between the overexpression of IGFBP2 and elevated MMP-2 expression.
|
12907597 |
2003 |
|
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Green tea polyphenol (-)-epigallocatechin 3-gallate inhibits MMP-2 secretion and MT1-MMP-driven migration in glioblastoma cells.
|
11853893 |
2002 |
|
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Five cases of glioblastomas with activated form of MMP-2 had MT1-MMP expressions.
|
10895974 |
2000 |
|
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Immunohistochemically, MT1-MMP and MT2-MMP are localized to the neoplastic astrocytes in glioblastoma samples (17/17 cases and 12/17 cases, respectively), which are also positive for MMP-2.
|
10027400 |
1999 |
|
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
HGF/SF also stimulated MMP-2 expression of other glioblastoma cell lines.
|
10389763 |
1999 |
|
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In medulloblastomas, the expression of mt1-MMP, mt2-MMP, and gelatinase A were also increased, but to a lesser extent than that observed in glioblastomas.
|
9708803 |
1998 |