MMP2, matrix metallopeptidase 2, 4313

N. diseases: 1021; N. variants: 43
Disease: Alzheimer's Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.050 Biomarker disease BEFREE Additionally according to the reported changes of MMP-2, MMP-9 and MAPKs (ERK, P38 and JNK) in AD pathology the hippocampal contents of these proteins were determined. 29225190 2018
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.050 AlteredExpression disease BEFREE These results suggest that behavioral stress aggravates AD pathology via generation of metabolic oxidative stress and MMP-2 down-regulation. 19012747 2009
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.050 AlteredExpression disease BEFREE The levels and activities of MMP-2, -3 and -9 are not increased in the frontal cortex in AD and are not related to Abeta load. 17971072 2008
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.050 AlteredExpression disease BEFREE Gelatinase A possesses a beta-secretase-like activity in cleaving the amyloid protein precursor of Alzheimer's disease. 8543065 1995
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.050 Biomarker disease BEFREE Proteolysis of A beta peptide from Alzheimer disease brain by gelatinase A. 7811262 1994